S.M. Pradhan¹, K.S.Katti¹, D.R. Katti¹

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.2, pp. 181-201, 2014, DOI:10.3970/cmes.2014.098.181

Abstract Multiscale modeling of collagen fibril is carried out by incorporating the material properties of collagen obtained from steered molecular dynamics into the finite element model of collagen fibril with inclusion of crosslinks. The results indicate that the nonbonded interactions between collagen and mineral contribute to the significant enhancement of the elastic modulus of collagen fibril at all the crosslink densities in both the low strain and high strain regimes. The crosslinks are found to play an important role in the mechanical response of collagen fibril, the enhancement in elastic modulus ranging from 5-11% for various More >

Qiubao Ouyang¹, Di Zhang^1,2, Xinhai Zhu³, Zhidong Han³

CMC-Computers, Materials & Continua, Vol.41, No.1, pp. 37-54, 2014, DOI:10.3970/cmc.2014.041.037

Abstract The present work is to investigate the failure mechanisms in the deformation of silicon carbide (SiC) particle reinforced aluminum Metal Matrix Composites (MMCs). To better deal with crack growth, a new numerical approach: the MLPG-Eshelby Method is used. This approach is based on the meshless local weak-forms of the Noether/Eshelby Energy Conservation Laws and it achieves a faster convergent rate and is of good accuracy. In addition, it is much easier for this method to allow material to separate in the material fracture processes, comparing to the conventional popular FEM based method. Based on a… More >

Hui ZHAO^1,2, Fan ZHANG^1*, Ling LI¹, Pingang HE¹, Yuzhi FANG¹

BIOCELL, Vol.37, No.3, pp. 77-83, 2013, DOI:10.32604/biocell.2013.37.077

Abstract The human neuroblastoma SH-SY5Y cell line has been used as a model to study mechanisms of neurotransmitter release. In order to study the mechanism of SH-SY5Y single cell exocytosis stimulated by different stimulants, including high K+, 3-(1-nitroso-2-pyrrolidinyl) pyridine and nicotine, a type of indium tin oxide (ITO) micro-pore electrode was used to obtain the corresponding amperometric response time. When the cell is stimulated by 0.1 M K+ , almost immediate exocytosis could be detected, due to the rapid depolarization of cell membrane. However, the stimulations with 1 mM nicotine and 3-(1-nitroso-2-pyrrolidinyl) pyridine result in a More >

J.B. Niu¹, L.L. Li², Q. Xu¹, Z.H. Xia^1,3

CMC-Computers, Materials & Continua, Vol.38, No.1, pp. 31-41, 2013, DOI:10.3970/cmc.2013.038.031

Abstract Crack deflection and penetration at the interface of multi-wall carbon nanotube/amorphous carbon composites were studied via molecular dynamics simulations. In-situ strength of double-wall nanotubes bridging a matrix crack was calculated under various interfacial conditions. The structure of the nanotube reinforcement -ideal multi-wall vs. multi-wall with interwall sp³ bonding - influences the interfacial sliding and crack penetration. When the nanotube/matrix interface is strong, matrix crack penetrates the outermost layer of nanotubes but it deflects within the nanotubes with certain sp³ interwall bond density, resulting in inner wall pullout. With increasing the sp³ interwall bond density, the fracture mode More >

LI-NA XU^1#, BI-NAN LU^2#, MING-MING HU¹, YOU-WEI XU¹, XU HAN¹, YAN QI¹, JIN-YONG PENG^1,3*

BIOCELL, Vol.36, No.3, pp. 113-120, 2012, DOI:10.32604/biocell.2012.36.113

Abstract Berberine, a constituent of some traditional Chinese medicinal plants, has been reported to have cytotoxicity effects on different human cancer cell lines. There is no available information about the effects and mechanism of action of berberine on human colon cancer cell line HCT-8. In this paper, the cytotoxicity of berberine on HCT-8 cancer cells was investigated by MTT assay, fluorescence microscopy and flow cytometry analysis. Our data revealed that berberine could significantly inhibit the growth of HCT-8 cells in a dose- and time-dependent manner. Morphology of apoptotic cells was studied with acridine orange/ ethidium bromide… More >

Zhen Luo^1,2, Nong Zhang,^1,3

CMC-Computers, Materials & Continua, Vol.28, No.1, pp. 27-56, 2012, DOI:10.3970/cmc.2012.028.027

Abstract This paper attempts to present a new multi-criteria topological optimization methodology for the systematic design of compliant micro-mechanisms. Instead of employing only the strain energy (SE) or the functional specifications such as mechanical efficiency (ME), in this study an alternative formulation representing multiple design requirements is included in the optimization to describe the performance of compliant mechanisms. In most conventional designs, SE is used to only measure the design requirement from the point of view of structures, while ME is usually applied to describe the mechanical performance of mechanisms. However, the design of a compliant… More >

Jin Ma¹, Jay C. Hanan¹, Ranga Komanduri¹, Hongbing Lu²

CMES-Computer Modeling in Engineering & Sciences, Vol.86, No.4, pp. 349-384, 2012, DOI:10.3970/cmes.2012.086.349

Abstract Amorphous metallic foams are an exciting class of materials for an array of high impact absorption applications, the mechanical behavior of which is only beginning to be characterized. To determine mechanical properties, guide processing, and engineer the microstructure for impact absorption, simulation of the mechanical properties is necessary as experimental determination alone can be expensive and time consuming. In this investigation, the material point method (MPM) with C1 continuous shape function is used to simulate the response of a bulk metallic glass (BMG) closed-cell foam (Pd42.5Cu30Ni7.5P20) under compression. The BMG foam was also tested experimentally… More >

Zhen Luo¹, Nong Zhang¹, Tao Wu^2,3

CMES-Computer Modeling in Engineering & Sciences, Vol.85, No.4, pp. 299-328, 2012, DOI:10.3970/cmes.2012.085.299

Abstract This paper presents a meshless Galerkin level-set method (MGLSM) for shape and topology optimization of compliant mechanisms of geometrically nonlinear structures. The design boundary of the mechanism is implicitly described as the zero level set of a Lipschitz continuous level set function of higher dimension. The moving least square (MLS) approximation is used to construct the meshless shape functions with the global Galerkin weak-form in terms of a set of arbitrarily distributed nodes. The MLS shape function is first employed to parameterize the level set function via the surface fitting rather than interpolation, and then… More >

Shihong Zhang^#, Ning Li, Zhihua Wang

Frontiers in Heat and Mass Transfer, Vol.2, No.3, pp. 1-5, 2011, DOI:10.5098/hmt.v2.3.3004

Abstract This article discussed the thermal efficiency, stability and pollutant emissions characteristics of the combustion of lean natural gas-air mixtures in Pd metal based honeycomb monoliths by means of experiments on a practical burner V. The chemistry at work in the monoliths was then investigated by the stagnation point flow reactor( SPFR), a fundamental experimental reactor. It was found that catalytic combustion inhibited the extent of gas-phase oxidation and increased the surface temperature of homogeneous ignition. According to the applications of catalytic combustion in the condenser boiler, the data of catalytic combustion condenser boiler V were More >

Murat Demiral, Anish Roy, Vadim V. Silberschmidt

The International Conference on Computational & Experimental Engineering and Sciences, Vol.17, No.3, pp. 87-88, 2011, DOI:10.3970/icces.2011.017.087

Abstract Industrial applications of Ti-based alloys especially in aerospace, marine and offshore industries have grown significantly over the years primarily due to their high strength, light weight as well as excellent temperature- and corrosion-resistance properties. Since these alloys are hard to machine, there is an obvious demand to develop simulation tools in order to analyze the material's behavior in machining processes, such as a turning, and to optimize process parameters. High levels of strains and strain rates accompanied by generated high temperatures characterize the deformation process in turning. The character of realisation of deformation mechanisms as… More >