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  • Open Access

    ARTICLE

    Effect of VirD4 on gastric epithelial-1 cells and its mechanism

    YANG YANG1,*, BENSHUAI YOU2, CHENGLIN ZHOU1,*

    BIOCELL, Vol.46, No.6, pp. 1557-1564, 2022, DOI:10.32604/biocell.2022.018326 - 07 February 2022

    Abstract The gene of Helicobacter pylori can encode three to four type IV secretory systems, of which a new gene region has been found in the H. pylori plasticity region. The coding products of this region can form a new T4SS named tfs3, but its function is unclear. This study investigated the effect of VirD4 recombinant protein in the tfs3 secretory system of the H. pylori clinical strain SBK on GES-1 cells. We observed changes in cell morphology after VirD4 treatment. Further analysis indicated that VirD4 increased inflammation by increasing the activation of NF-κB. VirD4 can also inhibited proliferation, More >

  • Open Access

    ARTICLE

    A Novel Feature Aggregation Approach for Image Retrieval Using Local and Global Features

    Yuhua Li1, Zhiqiang He1,2, Junxia Ma1,*, Zhifeng Zhang1,*, Wangwei Zhang1, Prasenjit Chatterjee3, Dragan Pamucar4

    CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.1, pp. 239-262, 2022, DOI:10.32604/cmes.2022.016287 - 24 January 2022

    Abstract The current deep convolution features based on retrieval methods cannot fully use the characteristics of the salient image regions. Also, they cannot effectively suppress the background noises, so it is a challenging task to retrieve objects in cluttered scenarios. To solve the problem, we propose a new image retrieval method that employs a novel feature aggregation approach with an attention mechanism and utilizes a combination of local and global features. The method first extracts global and local features of the input image and then selects keypoints from local features by using the attention mechanism. After… More >

  • Open Access

    ARTICLE

    Study on Triaxial Mechanical Properties and Micro Mechanism of Fly Ash Reinforced Cement Calcareous Sand

    Ben Li1, Na Li1,*, Chulei Fang1, Jun Hu2,*, Rong Yu3, Longxin Shu1, Kai Yao3, Fang Zhang1

    Journal of Renewable Materials, Vol.10, No.6, pp. 1693-1710, 2022, DOI:10.32604/jrm.2022.018475 - 20 January 2022

    Abstract In order to study the mechanical properties and micro-mechanism of industrial waste fly ash-reinforced cement calcareous sand (FCS), the triaxial unconsolidated undrained (UU) test and scanning electron microscope tests (SEM) were carried out on it. The results of UU test show that the peak stress and energy dissipation of the FCS sample first increase and then decrease with the increase in fly ash content. Fly ash enhances the cement calcareous sand by increasing both the cohesion and internal friction angle, and adding 10% content of fly ash gives the largest values. The SEM test results… More >

  • Open Access

    ARTICLE

    Mechanism behind Time Dependent Elasticity of Crumb Rubber-Nano-Asphalt Hybrids Using Discrete Relaxation Spectrum

    Lili Han1,2, Mulian Zheng2,*, Hongbing Guo1, Tao Wang3, Jiajian Zhu4, Pouria Hajikarimi5

    Journal of Renewable Materials, Vol.10, No.6, pp. 1727-1752, 2022, DOI:10.32604/jrm.2022.018467 - 20 January 2022

    Abstract Crumb rubber powder is a successfully used renewable material obtained from waste tire rubber, which has been incorporated into paving asphalt since the 1930s due to its good resistance to deformation and fatigue as well as its eco-friendly performance. In this study, carbon nanotubes and nano silica were incorporated into the terminal blend crumb rubber modified asphalt technology to remedy the issues of excessive desulfurization and degradation of ground tyre rubber with this technology. The mechanism behind the high temperature delayed elastic properties of the crumb rubber-nano-asphalt hybrids was experimentally investigated based on discrete relaxation… More >

  • Open Access

    ARTICLE

    Human Faces Detection and Tracking for Crowd Management in Hajj and Umrah

    Riad Alharbey1, Ameen Banjar1, Yahia Said2,3,*, Mohamed Atri4, Abdulrahman Alshdadi1, Mohamed Abid5

    CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 6275-6291, 2022, DOI:10.32604/cmc.2022.024272 - 14 January 2022

    Abstract Hajj and Umrah are two main religious duties for Muslims. To help faithfuls to perform their religious duties comfortably in overcrowded areas, a crowd management system is a must to control the entering and exiting for each place. Since the number of people is very high, an intelligent crowd management system can be developed to reduce human effort and accelerate the management process. In this work, we propose a crowd management process based on detecting, tracking, and counting human faces using Artificial Intelligence techniques. Human detection and counting will be performed to calculate the number… More >

  • Open Access

    ARTICLE

    Deep Learning-based Wireless Signal Classification in the IoT Environment

    Hyeji Roh, Sheungmin Oh, Hajun Song, Jinseo Han, Sangsoon Lim*

    CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 5717-5732, 2022, DOI:10.32604/cmc.2022.024135 - 14 January 2022

    Abstract With the development of the Internet of Things (IoT), diverse wireless devices are increasing rapidly. Those devices have different wireless interfaces that generate incompatible wireless signals. Each signal has its own physical characteristics with signal modulation and demodulation scheme. When there exist different wireless devices, they can suffer from severe Cross-Technology Interferences (CTI). To reduce the communication overhead due to the CTI in the real IoT environment, a central coordinator can be able to detect and identify wireless signals existing in the same communication areas. This paper investigates how to classify various radio signals using… More >

  • Open Access

    ARTICLE

    Attention-Based Deep Learning Model for Early Detection of Parkinson's Disease

    Mohd Sadiq1, Mohd Tauheed Khan2,*, Sarfaraz Masood3

    CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 5183-5200, 2022, DOI:10.32604/cmc.2022.020531 - 14 January 2022

    Abstract Parkinson's disease (PD), classified under the category of a neurological syndrome, affects the brain of a person which leads to the motor and non-motor symptoms. Among motor symptoms, one of the major disabling symptom is Freezing of Gait (FoG) that affects the daily standard of living of PD patients. Available treatments target to improve the symptoms of PD. Detection of PD at the early stages is an arduous task due to being indistinguishable from a healthy individual. This work proposed a novel attention-based model for the detection of FoG events and PD, and measuring the… More >

  • Open Access

    VIEWPOINT

    Therapeutic mechanisms and routes of delivery of mesenchymal stem cells in veterinary medicine: A point of view

    AMANDA BARACHO TRINDADE HILL1,2,*, JONATHAN EDWIN BARACHO TRINDADE HILL2

    BIOCELL, Vol.46, No.5, pp. 1173-1176, 2022, DOI:10.32604/biocell.2022.018637 - 06 January 2022

    Abstract Mesenchymal stem cells (MSCs) represent an important tool in veterinary regenerative medicine due to their ability to home to injury sites and secrete molecules that regulate niches into regenerative microenvironments. Successful cell therapy depends on many factors, including choice of administration route and application of understanding of cell potency and their therapeutic mechanisms. In this point of view, the authors leverage the tumultuous history of the field to demonstrate the need for clinicians to continually update themselves as new discoveries are made in order to avoid misalignments in the future, especially regarding administration routes and More >

  • Open Access

    ARTICLE

    Molecular mechanisms of Tanshinone IIA in Hepatocellular carcinoma therapy via WGCNA-based network pharmacology analysis

    HAN ZHAO1, JING GUO1, QINGJIA CHI2, MENG FANG1,*

    BIOCELL, Vol.46, No.5, pp. 1245-1259, 2022, DOI:10.32604/biocell.2022.018117 - 06 January 2022

    Abstract Hepatocellular carcinoma (HCC) is a worldwide malignant tumor that caused irreversible consequences. Tanshinone IIA has been shown to play a notable role in HCC treatment. However, the potential targets and associating mechanism of Tanshinone IIA against HCC remain unknown. We first screened out 105 overlapping genes by integrating the predicted targets of Tanshinone IIA from multiple databases and the differentially expressed genes of HCC from the Cancer Genome Atlas (TCGA) database. Then, we performed weighted gene co-expression network analysis (WGCNA) using the RNA-seq profiles of overlapping genes and HCC-related clinical information. 23 genes related to… More >

  • Open Access

    ARTICLE

    Study on the Deformation Mechanism of a Soft Rock Tunnel

    Jianhui Yang1, Kai Shen1, Shoudong Pan2, Shuren Wang3,*, Zhengsheng Zou3

    FDMP-Fluid Dynamics & Materials Processing, Vol.18, No.2, pp. 243-255, 2022, DOI:10.32604/fdmp.2022.016677 - 16 December 2021

    Abstract The large deformation of soft rock tunnel is one of the key problems to be overcome in the tunnel construction stage. In the present study, the deformation mechanism of a representative tunnel and some related countermeasures are investigated using field tests and engineering geological analysis. Owing to the scarce performances of methods based on other criteria such as small pipe spacing, anchor bolt length and steel frame spacing, a new support scheme is implemented and optimized. Results show that shear failure and bedding sliding are produced under high horizontal stress conditions. The low strength of More >

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