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  • Open Access

    ABSTRACT

    The Mechanical Mechanism of Cortical Folding on 3D Cerebral Organoids

    Zongkun Hou1, Shilei Hao1, Bochu Wang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 145-145, 2019, DOI:10.32604/mcb.2019.07077

    Abstract An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. The cortical folding has been implicated in neurodevelopmental disorders and yet its origins remain unknown. In vitro culture of 3D cerebral organoids from human pluripotent stem cells has been used to study the fundamental mechanisms of mammalian neurodevelopment and characteristics of human brain development. Here, we explores the mechanism of boundary limitation on the formation of gyri and sulci through the self-organization of human brain organoids. The structure of cerebral organoids was analyzed by morphology observation, pathology… More >

  • Open Access

    ABSTRACT

    Differential Organization of Airway Smooth Muscle Cells on Tubular Surface as A Novel Mechanobiology Mechanism of Airway Tissue Morphogenesis

    Linhong Deng1,*, Yang Jin2, Mingzhi Luo1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 80-80, 2019, DOI:10.32604/mcb.2019.07370

    Abstract Airway smooth muscle cells (ASMCs) exists within the bronchial airway wall in a form of spirally winding bundles [1]. This pattern emerges early during embryonic development and is involved in airway branching [2], providing the airway appropriate contractile capacity and resistance to circumferential tension in health or causing excessive airway narrowing in disease such as asthma. Despite its importance, the cause of ASMCs self-organization remains largely a mystery. Previously, we have demonstrated in 2D that ASMCs can sense the curvature in their microenvironment and change behaviors in differentiation, orientation and migration accordingly [3]. Here we… More >

  • Open Access

    ABSTRACT

    Effect and Mechanism of Kir2.1 Channel Overexpression on Transdifferentiation of Endothelial Progenitor Cells

    Jifeng Li1,#, Yanting He1,#, Xiaoyun Zhang1, Hong Li1, Xiumei Guan1, Min Cheng1,*, Xiaodong Cui1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 89-89, 2019, DOI:10.32604/mcb.2019.05753

    Abstract Objective: The propose of the study is to investigate the specific effects of the mechanically sensitive channel Kir2.1 on the transdifferentiation of EPCs so as to understand the molecular mechanism of pathological vascular remodeling. Methods: Endothelial progenitor cells (EPCs) were isolated from rat bone marrow and cultured in EGM2 medium in vitro. The recombinant lentiviral vectors carrying Kir2.1 (NM_017296.1) gene was designed and constructed in order to overexpress the gene. The smooth muscle cells (SMCs) molecules marker on EPCs, such as α-SMA, FSP1 and α-SM22, were detected by RT-PCR and cellular immunofluorescence. In addition, cell angiogenic capacity… More >

  • Open Access

    ARTICLE

    Analysis of Underlay Cognitive Radio Networks Based on Interference Cancellation Mechanism

    Lei Wang1, Jian Liu1,*, Alan Yang2

    Journal of Information Hiding and Privacy Protection, Vol.1, No.3, pp. 119-133, 2019, DOI:10.32604/jihpp.2019.07296

    Abstract In this paper, we study the state-dependent interference channel, where the Rayleigh channel is non-causally known at cognitive network. We propose an active secondary transmission mechanism with interference cancellation technique according to the ON-OFF status of primary network. the secondary transmission mechanism is divided into four cases according to the active state of the primary user in the two time slots. For these interference cases, numerical results are provided to show that active interference cancellation mechanism significantly reduces the secondary transmission performance in terms of secondary outage probability and energy efficiency. More >

  • Open Access

    ARTICLE

    An Analysis of the Stretching Mechanism of a Liquid Bridge in Typical Problems of Dip-Pen Nanolithography By Using Computational Fluid Dynamics

    Cheng Zhang1, *, Mingge Wu1

    FDMP-Fluid Dynamics & Materials Processing, Vol.15, No.4, pp. 459-469, 2019, DOI:10.32604/fdmp.2019.08477

    Abstract A computational study of the stretching mechanism of a liquid bridge and the effect of the liquid properties on the DPN (dip-pen nanolithography) process is presented. The results show that the viscosity and contact angle can have an appreciable influence on these processes. The greater the viscosity, the harder the liquid bridge is to break, which allows more molecular transfer during the DPN spotting process. Besides, when the contact angle between the liquid and substrate is less than 60 degrees, the time required to stretch the bridge and break it grows with the contact More >

  • Open Access

    ARTICLE

    Investigation of the Mechanism of Grout Penetration in Intersected Fractures

    Yanxu Guo1, Peng Zhao2, Qingsong Zhang1, Rentai Liu1,*, Lianzhen Zhang3, Yankai Liu1

    FDMP-Fluid Dynamics & Materials Processing, Vol.15, No.4, pp. 321-342, 2019, DOI:10.32604/fdmp.2019.07844

    Abstract To study the penetration mechanism of cement-based slurry in intersected fractures during grouting and the related pressure distribution, we have used two different variants of cement, namely, basic cement slurry and fast-setting cement slurry. The influence of a retarder, time-varying viscosity, fracture width and location of injection hole is also considered. A finite element software is used to implement two and three-dimensional numerical models for grouting of intersected fractures in hydrostatic conditions. Results show that there are significant differences in the diffusion morphology and pressure distribution depending on the considered cement slurry. Retarder can More >

  • Open Access

    ARTICLE

    A Dynamic Memory Allocation Optimization Mechanism Based on Spark

    Suzhen Wang1, Shanshan Geng1, Zhanfeng Zhang1, Anshan Ye2, Keming Chen2, Zhaosheng Xu2, Huimin Luo2, Gangshan Wu3,*, Lina Xu4, Ning Cao5

    CMC-Computers, Materials & Continua, Vol.61, No.2, pp. 739-757, 2019, DOI:10.32604/cmc.2019.06097

    Abstract Spark is a distributed data processing framework based on memory. Memory allocation is a focus question of Spark research. A good memory allocation scheme can effectively improve the efficiency of task execution and memory resource utilization of the Spark. Aiming at the memory allocation problem in the Spark2.x version, this paper optimizes the memory allocation strategy by analyzing the Spark memory model, the existing cache replacement algorithms and the memory allocation methods, which is on the basis of minimizing the storage area and allocating the execution area according to the demand. It mainly including two… More >

  • Open Access

    ARTICLE

    An Efficient Quantum Key Distribution Protocol with Dense Coding on Single Photons

    Hao Xiao1,*, Jun Zhang2, Wenhua Huang3, Mi Zhou4, Wencheng Hu5

    CMC-Computers, Materials & Continua, Vol.61, No.2, pp. 759-775, 2019, DOI:10.32604/cmc.2019.06085

    Abstract Combined with the dense coding mechanism and the bias-BB84 protocol, an efficient quantum key distribution protocol with dense coding on single photons (QDKD-SP) is proposed. Compared with the BB84 or bias-BB84 protocols based on single photons, our QDKD-SP protocol has a higher capacity without increasing the difficulty of its experiment implementation as each correlated photon can carry two bits of useful information. Compared with the quantum dense key distribution (QDKD) protocol based on entangled states, our protocol is more feasible as the preparation and the measurement of a single-photon quantum state is not difficult with More >

  • Open Access

    ARTICLE

    Keyphrase Generation Based on Self-Attention Mechanism

    Kehua Yang1,*, Yaodong Wang1, Wei Zhang1, Jiqing Yao2, Yuquan Le1

    CMC-Computers, Materials & Continua, Vol.61, No.2, pp. 569-581, 2019, DOI:10.32604/cmc.2019.05952

    Abstract Keyphrase greatly provides summarized and valuable information. This information can help us not only understand text semantics, but also organize and retrieve text content effectively. The task of automatically generating it has received considerable attention in recent decades. From the previous studies, we can see many workable solutions for obtaining keyphrases. One method is to divide the content to be summarized into multiple blocks of text, then we rank and select the most important content. The disadvantage of this method is that it cannot identify keyphrase that does not include in the text, let alone… More >

  • Open Access

    REVIEW

    Targeting Glycinebetaine for Abiotic Stress Tolerance in Crop Plants: Physiological Mechanism, Molecular Interaction and Signaling

    Mirza Hasanuzzaman1,*, Aditya Banerjee2, M. H. M. Borhannuddin Bhuyan3,4, Aryadeep Roychoudhury2,*, Jubayer Al Mahmud5 and Masayuki Fujita3

    Phyton-International Journal of Experimental Botany, Vol.88, No.3, pp. 185-221, 2019, DOI:10.32604/phyton.2019.07559

    Abstract In the era of climate change, abiotic stresses (e.g., salinity, drought, extreme temperature, flooding, metal/metalloid(s), UV radiation, ozone, etc.) are considered as one of the most complex environmental constraints that restricts crop production worldwide. Introduction of stress-tolerant crop cultivars is the most auspicious way of surviving this constraint, and to produce these types of tolerant crops. Several bioengineering mechanisms involved in stress signaling are being adopted in this regard. One example of this kind of manipulation is the osmotic adjustment. The quarternary ammonium compound glycinebetaine (GB), also originally referred to as betaine is a methylated… More >

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