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  • Open Access

    ARTICLE

    Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells

    QINGXIN LIU , XIANGGUI CHEN, GUOLIN YANG1 , XUEWEN MIN3 , AND MAOXIAN DENG1,*

    BIOCELL, Vol.35, No.3, pp. 71-80, 2011, DOI:10.32604/biocell.2011.35.071

    Abstract Apigenin, a nonmutagenic flavonoid, has been shown to possess free radical scavenging activities, anticarcinogenic properties, antioxidant and anti-inflammatory effects. Recently, apigenin was reported to cause gastric relaxation in murine. To assess possible effects of apigenin on migration of bladder smooth muscle (SM) cell, we isolated SM cells from peri-cancer tissue of human bladder and established a cell model that was capable to overexpress transiently MEKK1 (MEK kinase 1). Results showed that overexpression of active human MEKK1 by adenoviruses infection induced migration of human bladder smooth muscle (hBSM) cells and phosphorylation of MAPKs, ERK, JNK and p38, which are the downstream… More >

  • Open Access

    ABSTRACT

    Matrix Stiffness Promotes Hepatoma Cell Glycolysis and Migration Through YAP-Mediated Mechanotransduction

    Qiuping Liu1, Guanbin Song1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 127-127, 2019, DOI:10.32604/mcb.2019.07105

    Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide. Increased matrix stiffness of extracellular matrix (ECM) is commonly associated with HCC. During tumour formation and expansion, increasing glucose metabolism is necessary for unrestricted growth of tumour cells. Yet, the correlation between matrix stiffness and glucose metabolism in the development of HCC remains unknown. In this study, we aim to investigate the effect of matrix stiffness on glucose metabolism and migration of MHCC97L and HepG2 hepatoma cells, and explore the mechanotransduction involved in this process. Polyacrylamide hydrogels with stiffness gradients of 6, 25, 54 kPa were produced… More >

  • Open Access

    ABSTRACT

    Immune Cells Migrating through the Brain Endothelia Junctions Served as Shuttles for Nanoparticles Delivery to Glioblastoma

    Gloria B. Kim1,†, Qiong Wei2,†, Virginia Aragon-Sanabria1, Sulin Zhang2, Jian Yang1, Cheng Dong1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 15-15, 2019, DOI:10.32604/mcb.2019.07137

    Abstract Most cells survive and grow by attaching and spreading on a substrate. They generate internal tension that contracts the cell body and thus exert tractions on the underlying substrate through focal adhesions. Traction force also plays a critical role in many biological processes, such as inflammation, metastasis, and angiogenesis. Thus, measuring the cell traction force provides valuable information on understanding the underlying mechanism of these biological processes. Here, a traction force microscopy (TFM) method using super thin hydrogels composed of immobilized fluorescent beads was utilized to quantify the mechanical forces generated during the transmigration of Jurkat cells (a human T… More >

  • Open Access

    ABSTRACT

    Micro-Scale Numerical Simulation of Water Migration in Plant-Based Materials During Isothermal Drying

    Peng Wang, Huaxing Zhai, Gehan Liu, Xiaohua Wu, Dongliang Sun* and Bo Yu

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.22, No.3, pp. 149-150, 2019, DOI:10.32604/icces.2019.04963

    Abstract The isothermal drying of plant-based material, such as fruits and vegetables, is the most widely used drying technique to stabilize materiel and to increase their shelf life. However, drying is a high energy-consuming industry process, in which water removal obviously affects the quality of dried products. Therefore, it is crucial to understand the water migration mechanisms during drying for improving energy efficiency and ensuring better quality.
    Plant-based material generally has highly porous characteristics, and the major part of the water (about 80-90%) is present in the intracellular space, but not in the intercellular (pore) space. There are three pathways… More >

  • Open Access

    ARTICLE

    A Fully Coupled Finite Element Model of Landfill Gas Migration in a Partially Saturated Soil

    W. J. Ferguson1, B. Palananthakumar2

    CMES-Computer Modeling in Engineering & Sciences, Vol.8, No.3, pp. 201-216, 2005, DOI:10.3970/cmes.2005.008.201

    Abstract Environmental and safety issues associated with landfill gas require the control of off-site migration. Mathematical modelling can assist in the understanding of the processes and mechanisms controlling gas migration from municipal waste disposal sites. This paper presents the development and application of a mathematical model that simulates landfill gas migration within a partially saturated soil. This model accounts for two-phase flow and incorporates multi-component (methane, carbon dioxide, dry air and moisture) transport in the gas and liquid phases together with concomitant heat migration. The governing system of fully coupled non-linear partial differential equations of the model have been derived from… More >

  • Open Access

    ARTICLE

    Antioxidant Migration Studies in Chitosan Films Incorporated with Plant Extracts

    Victor Gomes Lauriano Souza1, Patrícia Freitas Rodrigues2, Maria Paula Duarte1, Ana Luísa Fernando1*

    Journal of Renewable Materials, Vol.6, No.5, pp. 548-558, 2018, DOI:10.7569/JRM.2018.634104

    Abstract The aim of this work was to develop an active biopolymer based on chitosan by incorporating natural antioxidants. Five essential oils (ginger, rosemary, sage, tea tree and thyme) and six hydro-alcoholic extracts (from ginger, green and black tea, kenaf leaves, rosemary and sage plants) were tested. Migration assays were carried out to evaluate the films' activity, and total phenolic content and antioxidant activity were monitored in the simulant during storage. Interaction between natural compounds and polymeric matrix was evaluated by FTIR spectroscopy. The diffusion of the phenolic compounds was not detected in the films incorporated with hydro-alcoholic extracts (HAEs), indicating… More >

  • Open Access

    ARTICLE

    A Coupled Friction-Poroelasticity Model of Chimneying Shows that Confined Cells Can Mechanically Migrate Without Adhesions

    Solenne Mondésert-Deveraux1, *, Rachele Allena2, Denis Aubry1

    Molecular & Cellular Biomechanics, Vol.15, No.3, pp. 155-176, 2018, DOI: 10.3970/mcb.2018.03053

    Abstract Cell migration is the cornerstone of many biological phenomena such as cancer metastasis, immune response or organogenesis. Adhesion-based motility is the most renown and examined motility mode, but in an adhesion-free confined environment or simply to achieve a higher migration speed, cells can adopt a very interesting bleb-based migration mode called “chimneying”. This mode rests on the sharp synchronization between the active contraction of the cells uropod and the passive friction force between the cell and the confining surface. In this paper, we propose a one dimensional poroelastic model of chimneying which considers the active strains of the cell, but,… More >

  • Open Access

    ARTICLE

    A Coupled Mathematical Model of Cell Migration, Vessel Cooption and Tumour Microenvironment during the Initiation of Micrometastases

    Yan Cai1,2,3, Jie Wu4, Zhiyong Li1,2

    Molecular & Cellular Biomechanics, Vol.12, No.4, pp. 231-248, 2015, DOI:10.3970/mcb.2015.012.231

    Abstract We propose a coupled mathematical model for the detailed quantitative analyses of initial microtumour and micrometastases formation by including cancer cell migration, host vessel cooption and changes in microenvironment. Migrating cells are included as a new phenotype to describe the migration behaviour of malignant tumour cells. Migration probability of a migrating cell is assumed to be influenced by local chemical microenvironment. Pre-existing vessel cooption and remodelling are introduced according to the local haemodynamical microenvironment, such as interstitial pressure and vessel wall permeability. After the tumour cells and tumour vessels distribution are updated, the chemical substances are coupled calculated with the… More >

  • Open Access

    ARTICLE

    Mechanical Modelling of Confined Cell Migration Across Constricted-curved Micro-channels

    R. Allena*,†

    Molecular & Cellular Biomechanics, Vol.11, No.3, pp. 185-208, 2014, DOI:10.3970/mcb.2014.011.185

    Abstract Confined migration is a crucial phenomenon during embryogenesis, immune response and cancer. Here, a two-dimensional finite element model of a HeLa cell migrating across constricted–curved micro-channels is proposed. The cell is modelled as a continuum with embedded cytoplasm and nucleus, which are described by standard Maxwell viscoelastic models. The decomposition of the deformation gradient is employed to define the cyclic active strains of protrusion and contraction, which are synchronized with the adhesion forces between the cell and the substrate. The micro-channels are represented by two rigid walls and exert an additional viscous force on the cell boundaries. Five configurations have… More >

  • Open Access

    ARTICLE

    Cell Migration and Cell-Cell Interaction in the Presence of Mechano-Chemo-Thermotaxis

    S.J. Mousavi, M.H. Doweidar∗,†, M. Doblaré

    Molecular & Cellular Biomechanics, Vol.10, No.1, pp. 1-25, 2013, DOI:10.3970/mcb.2013.010.001

    Abstract Although there are several computational models that explain the trajectory that cells take during migration, till now little attention has been paid to the integration of the cell migration in a multi-signaling system. With that aim, a generalized model of cell migration and cell-cell interaction under multisignal environments is presented herein. In this work we investigate the spatio-temporal cell-cell interaction problem induced by mechano-chemo-thermotactic cues. It is assumed that formation of a new focal adhesion generates traction forces proportional to the stresses transmitted by the cell to the extracellular matrix. The cell velocity and polarization direction are calculated based on… More >

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