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  • Open Access

    ARTICLE

    A Computational Approach to Estimating a Lubricating Layer in Concrete Pumping

    Seon Doo Jo1, Chan Kyu Park2, Jae Hong Jeong2, Seung Hoon Lee2, Seung Hee Kwon3

    CMC-Computers, Materials & Continua, Vol.27, No.3, pp. 189-210, 2012, DOI:10.3970/cmc.2011.027.189

    Abstract When concrete is being pumped, a lubricating layer forms at the interface of the inner concrete and the wall of the pipe. The lubricating layer is one of the most dominant factors in determining the pumping capability, yet no study has endeavored to quantitatively estimate the thickness and rheological properties of the layer. Recently, there has been a growing demand for large-scale construction under extreme conditions, such as high-rise buildings and super-long span bridges. This demand has heightened the need for more accurate predictions of pumpability.
    A possible mechanism that contributes to the formation of the More >

  • Open Access

    ARTICLE

    Thermodiffusion Applications in MEMS, NEMS and Solar Cell Fabrication by Thermal Metal Doping of Semiconductors

    Morteza Eslamian1,2, M. Ziad Saghir1,3

    FDMP-Fluid Dynamics & Materials Processing, Vol.8, No.4, pp. 353-380, 2012, DOI:10.3970/fdmp.2012.008.353

    Abstract In this paper recent advances pertinent to the applications of thermodiffusion or thermomigration in the fabrication of micro and nano metal-doped semiconductor-based patterns and devices are reviewed and discussed. In thermomigration, a spot, line, or layer of a p-type dopant, such as aluminum, which is deposited on a semiconductor surface, penetrates into the semiconductor body due to the presence of a temperature gradient applied across the wafer body. The trails of p-doped regions within an n-type semiconductor, in the form of columns or walls, may be used for several applications, such as the isolation of More >

  • Open Access

    ARTICLE

    Apigenin inhibits cell migration through MAPK pathways in human bladder smooth muscle cells

    QINGXIN LIU , XIANGGUI CHEN, GUOLIN YANG1 , XUEWEN MIN3 , AND MAOXIAN DENG1,*

    BIOCELL, Vol.35, No.3, pp. 71-80, 2011, DOI:10.32604/biocell.2011.35.071

    Abstract Apigenin, a nonmutagenic flavonoid, has been shown to possess free radical scavenging activities, anticarcinogenic properties, antioxidant and anti-inflammatory effects. Recently, apigenin was reported to cause gastric relaxation in murine. To assess possible effects of apigenin on migration of bladder smooth muscle (SM) cell, we isolated SM cells from peri-cancer tissue of human bladder and established a cell model that was capable to overexpress transiently MEKK1 (MEK kinase 1). Results showed that overexpression of active human MEKK1 by adenoviruses infection induced migration of human bladder smooth muscle (hBSM) cells and phosphorylation of MAPKs, ERK, JNK and More >

  • Open Access

    ARTICLE

    Design Optimization of a Conical Annular Centrifugal Contractor

    M. N. Noui-Mehidi1

    FDMP-Fluid Dynamics & Materials Processing, Vol.7, No.2, pp. 141-152, 2011, DOI:10.3970/fdmp.2011.007.141

    Abstract The present work is concerned with a numerical study of the performance of a conical annular centrifugal contractor through the analysis of the flow properties when the apex angle is changed for different imposed axial flows. The calculations revealed the advantage of using conical annular centrifugal contractors compared to the cylindrical annular centrifuges. The study is conducted by a comparison analysis of the hydrodynamics of fluid flow in both conical and cylindrical contractors where moderate axial flows are imposed. In both systems the outer body is stationary while the inner rotor is maintained at constant More >

  • Open Access

    ARTICLE

    Brief Note: CD44 is involved in CXCL-12 induced acute myeloid leukemia HL-60 cell polarity

    LIPING ZHOU*, XIAOLIN GUO, JING BA, LIANSHUANG ZHA

    BIOCELL, Vol.34, No.2, pp. 91-94, 2010, DOI:10.32604/biocell.2010.34.091

    Abstract CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internalization of CXCR4 and facilitated the formation of lamellipodia and uropod in acute leukemia cell line HL-60. CXCL12 also induced CD44 translocation into the uropod, while CD44 remained evenly distributed on the untreated cell membranes. Results suggest More >

  • Open Access

    ARTICLE

    Effect of Dextran 500 on Radial Migration of Erythrocytes in Postcapillary Venules at Low Flow Rates

    Sangho Kim∗,†, Peng Kai Ong*, Paul C. Johnson

    Molecular & Cellular Biomechanics, Vol.6, No.2, pp. 83-92, 2009, DOI:10.3970/mcb.2009.006.083

    Abstract Recently, we reported that collision efficiency (fraction of total collisions that result in the formation of aggregates) between red blood cells was an important factor in the formation of aggregates in postcapillary venules. In the present study, we focus on how high molecular weight dextran influences the overall radial migration trend of red blood cells in the postcapillary venule along a longitudinal distance of 50 μm from the bifurcation which would in turn affect collision behavior of these cells. A radial migration index, which defines the extent of radial migration of individual cells relative to the… More >

  • Open Access

    ARTICLE

    Peridynamic Simulation of Electromigration

    Walter Gerstle1, Stewart Silling2, David Read3, Vinod Tewary4, Richard Lehoucq5

    CMC-Computers, Materials & Continua, Vol.8, No.2, pp. 75-92, 2008, DOI:10.3970/cmc.2008.008.075

    Abstract A theoretical framework, based upon the peridynamic model, is presented for analytical and computational simulation of electromigration. The framework allows four coupled physical processes to be modeled simultaneously: mechanical deformation, heat transfer, electrical potential distribution, and vacancy diffusion. The dynamics of void and crack formation, and hillock and whisker growth can potentially be modeled. The framework can potentially be applied at several modeling scales: atomistic, crystallite, multiple crystallite, and macro. The conceptual simplicity of the model promises to permit many phenomena observed in microchips, including electromigration, thermo-mechanical crack formation, and fatigue crack formation, to be More >

  • Open Access

    ARTICLE

    Geometric Confinement Influences Cellular Mechanical Properties II -- Intracellular Variances in Polarized Cells

    Judith Su, Ricardo R. Brau, Xingyu Jiang, George M. Whitesides§, Matthew J. Lang, Peter T. C. So||

    Molecular & Cellular Biomechanics, Vol.4, No.2, pp. 105-118, 2007, DOI:10.3970/mcb.2007.004.105

    Abstract During migration, asymmetrically polarized cells achieve motion by coordinating the protrusion and retraction of their leading and trailing edges, respectively. Although it is well known that local changes in the dynamics of actin cytoskeleton remodeling drive these processes, neither the cytoskeletal rheological properties of these migrating cells are well quantified nor is it understand how these rheological properties are regulated by underlying molecular processes. In this report, we have used soft lithography to create morphologically polarized cells in order to examine rheological differences between the front and rear zone of an NIH 3T3 cell posed More >

  • Open Access

    ARTICLE

    Slow Viscous Migration of a Conducting Solid Particle under the Action of Uniform Ambient Electric and Magnetic Fields

    A. Sellier1

    CMES-Computer Modeling in Engineering & Sciences, Vol.21, No.2, pp. 105-132, 2007, DOI:10.3970/cmes.2007.021.105

    Abstract We examine the low-Reynolds-number migration of a conducting and arbitrarily-shaped solid particle freely immersed in a metal liquid of different conductivity when subject to uniform ambient electric and magnetic fields. The boundary formulation established elsewhere for an insulating particle is extended and the incurred particle's rigid-body motion is then obtained by determinating a very few surface quantities on the particle's surface. The behavior of either oblate or prolate conducting spheroids is analytically investigated and the poposed procedure for the challenging case of other non-trivial geometries is implemented and benchmarked against those solutions. The numerical implementation More >

  • Open Access

    ARTICLE

    TNFα increases in vitro migration of human HPV18-positive SW756 cervical carcinoma cells

    K. HIDALGO1, I. G. ROJAS2, A. B. PENISSI3, M. I. RUDOLPH1

    BIOCELL, Vol.29, No.3, pp. 303-311, 2005, DOI:10.32604/biocell.2005.29.303

    Abstract TNFα has been associated with both, tumor survival and apoptosis. This cytokine is also involved in promoting cell migration during wound healing and tumorigenesis. SW756 is a HPV18-positive cervical carcinoma cell line, which has been used to study different mechanisms of cervical cancer progression. An in vitro assay of scratch wound healing onto monolayers of SW756 cells was used to assess the effect of TNFα on cell migration into a wound space. It was found that SW756 cells have the ability to migrate, but not proliferate in response to scratch wounding in a serum-free medium supplemented More >

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