Marilena Lucarelli1, Antonietta M. Gatti2, Graziana Savarino1, Paola Quattroni1, Lucia Martinelli1, Emanuela Monari2, Diana Boraschi1
European Cytokine Network, Vol.15, No.4, pp. 339-346, 2004
Abstract Nano-sized particles of ceramic and metallic materials are generated by high-tech industrial
activities, and can be generated from worn-out replacement and prosthetic implants. The interaction with the
human body of such nanoparticles has been investigated, with a particular emphasis on innate defence
mechanisms. Human macrophages (PMA-differentiated myelomonocytic U-937 cells) were exposed in vitro to
non-toxic concentrations of TiO2, SiO2, ZrO2, or Co nanoparticles, and their inflammatory response (expression
of TLR receptors and co-receptors, and cytokine production) was examined. Expression of TLR receptors was
generally unaffected by exposure to the different nanoparticles, except for some notable cases. Exposure… More >