Gilles Molgat, Marjan Afrouzian, Kiril Trpkov

Canadian Journal of Urology, Vol.12, No.5, pp. 2837-2840, 2005

Abstract Renal medullary carcinoma is rare and extremely aggressive neoplasm that typically affects young patients of African decent who demonstrate sickle cell trait or disease. Since the original description in 1995, only few cases have been reported outside the United States. A 29 year-old Canadian male of Afro-Caribbean decent with sickle cell trait developed right-sided hemiparesis due to brain infarct. During the clinical work-up, a 3 cm renal tumor was detected in a horseshoe kidney. The patient died suddenly 2 weeks after the presentation of massive non-neoplastic pulmonary thromboembolism, confirmed at autopsy. The final diagnosis of More >

Savino M. Di Stasi, Antonella Giannantoni, Robert L. Stephen^*, Luigi Storti, Francesco Attisani, Andrea De Carolis, Guido Virgili

Canadian Journal of Urology, Vol.12, No.6, pp. 2895-2898, 2005

Abstract A 59 year old male presented with a 4 month history of lower urinary tract symptoms.
Exhaustive urological investigations revealed papillary tumors and carcinoma in situ extending from the prostatic urethra, throughout the bladder, up both ureters and into the renal pelves.
Tumors were resected where possible and then bacillus Calmette-Guèrin (BCG) and mitomycin C (MMC) were infused sequentially through bilateral nephrostomy tubes for a total of six BCG and three MMC instillations.
Follow up 1 month post treatment demonstrated a complete response which persisted for 2 years. Then there appeared a solitary papillomatous recurrence in the More >

Ashley Cox, Christopher Y. Nguan, Patrick P. W. Luke

Canadian Journal of Urology, Vol.12, No.6, pp. 2887-2890, 2005

Abstract The majority of immunosuppressive agents used to prevent rejection in transplant patients have also been shown to increase malignancy risk. Renal transplant patients are dependent upon their solitary allograft kidneys in order to remain dialysis free, and the discovery of a primary malignancy within the allograft poses a therapeutic dilemma. We describe two cases of primary renal allograft malignancies and discuss nephron-preserving surgical treatment. Furthermore, we discuss the potential anti-tumor role of the immunosuppressive agent sirolimus in the treatment of these complex patients. More >

K. HIDALGO¹, I. G. ROJAS², A. B. PENISSI³, M. I. RUDOLPH¹

BIOCELL, Vol.29, No.3, pp. 303-311, 2005, DOI:10.32604/biocell.2005.29.303

Abstract TNFα has been associated with both, tumor survival and apoptosis. This cytokine is also involved in promoting cell migration during wound healing and tumorigenesis. SW756 is a HPV18-positive cervical carcinoma cell line, which has been used to study different mechanisms of cervical cancer progression. An in vitro assay of scratch wound healing onto monolayers of SW756 cells was used to assess the effect of TNFα on cell migration into a wound space. It was found that SW756 cells have the ability to migrate, but not proliferate in response to scratch wounding in a serum-free medium supplemented More >

Cheng Dong^1,2,3, Margaret J. Slattery^2,3, Shile Liang³, Hsin-Hsin Peng²

Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 145-160, 2005, DOI:10.3970/mcb.2005.002.145

Abstract Attachment of tumor cells to the endothelium (EC) under flow conditions is critical for the migration of tumor cells out of the vascular system to establish metastases. Innate immune system processes can potentially promote tumor progression through inflammation dependant mechanisms.\nobreakspace {} White blood cells, neutrophils (PMN) in particular, are being studied to better understand how the host immune system affects cancer cell adhesion and subsequent migration and metastasis. Melanoma cell interaction with the EC is distinct from PMN-EC adhesion in the circulation. We found PMN increased melanoma cell extravasation, which involved initial PMN tethering on… More >

Uzair B. Chaudhary¹, David L. Milling¹, Nabil K. Bissada²

Canadian Journal of Urology, Vol.11, No.1, pp. 2136-2138, 2004

Abstract Hypercalcemia associated with transitional cell carcinoma (TCC) is rarely encountered. We report a case of TCC of bladder with documented production of parathyroid hormone related protein (PTHrP). Our patient had a rapidly progressive course and died 2 months after radical cystectomy. Literature suggests that these patients present with advanced stage and carry a poor prognosis. The histopathologic features, treatment and prognosis associated with this rare paraneoplastic syndrome are reviewed. More >

Scott Bagnell¹, Richard Choo^1,2, Laurence H. Klotz^1,2, Suman Chaterjee¹

Canadian Journal of Urology, Vol.11, No.2, pp. 2194-2199, 2004

Abstract Objective: To evaluate the practice patterns of Canadian urologists in the management of stage I testicular seminoma.
Methods: A survey was conducted with a three-page questionnaire among Canadian urologists between July and November 2002.
Results: The overall response rate was 48%. The total number of completed and partially completed questionnaires was 198 and 212, respectively. Ninety-four responders described their practice as university-affiliated teaching centre, while 118 reported community-based or private practice. All ordered CT abdomen/pelvis with either chest x-ray or CT scan of chest for staging investigation. Only 1% would order a lymphangiogram. About one third would not… More >

Kevin B. Morrison, Iain W. McAuley, John F. Kinahan

Canadian Journal of Urology, Vol.11, No.3, pp. 2309-2311, 2004

Abstract A seven centimeter supra-renal mass was discovered in a 62-year old patient who presented with gross hematuria and a superficial bladder tumor. The supra-renal mass was resected laparoscopically and the final pathology revealed a benign schwannoma. The epidemiology, diagnostic features and treatment options for this rare peripheral nerve sheath tumor are reviewed. More >

Jean-Baptiste Lattouf, Michael Mc Cormack, Louise Yelle, Rachid Hadjeres, Fred Saad

Canadian Journal of Urology, Vol.11, No.4, pp. 2350-2351, 2004

Abstract We present a case of a pathologic stage 1, right sided, non-seminomatous germ cell tumor recurrence in the left seminal vesicle, 20 years after initial diagnosis and treatment. The patient was treated with three salvage cycles of bleomycin, etoposide, and cisplatinum. At 24 months of follow-up after completion of chemotherapy, digital rectal and TRUS examinations revealed complete resolution of the lesion. We believe that this tumor is a late metastasis to the contralateral seminal vesicle. More >

Richard D. Sowery, D. Robert Siemens

Canadian Journal of Urology, Vol.11, No.5, pp. 2407-2410, 2004

Abstract Objective: To characterize tumor growth of patients managed conservatively for renal cell carcinoma.
Methods: Patients electing conservative management of radiographically determined renal cell carcinomas were referred to a surveillance database. Exclusion criteria consisted of locally advanced disease (>T2) and those with metastatic disease. Clinical follow-up included renal imaging with ultrasound or computed tomography at least every 6 months.
Results: Twenty-two patients were originally managed conservatively, two of whom subsequently underwent nephrectomy because of rapid tumor growth. Mean follow-up was 26 months. Mean tumor volume and diameter at presentation was 62.4 cc and 4.08 cm respectively. Overall tumor growth More >