Kevin B. Morrison, Iain W. McAuley, John F. Kinahan

Canadian Journal of Urology, Vol.11, No.3, pp. 2309-2311, 2004

Abstract A seven centimeter supra-renal mass was discovered in a 62-year old patient who presented with gross hematuria and a superficial bladder tumor. The supra-renal mass was resected laparoscopically and the final pathology revealed a benign schwannoma. The epidemiology, diagnostic features and treatment options for this rare peripheral nerve sheath tumor are reviewed. More >

Jean-Baptiste Lattouf, Michael Mc Cormack, Louise Yelle, Rachid Hadjeres, Fred Saad

Canadian Journal of Urology, Vol.11, No.4, pp. 2350-2351, 2004

Abstract We present a case of a pathologic stage 1, right sided, non-seminomatous germ cell tumor recurrence in the left seminal vesicle, 20 years after initial diagnosis and treatment. The patient was treated with three salvage cycles of bleomycin, etoposide, and cisplatinum. At 24 months of follow-up after completion of chemotherapy, digital rectal and TRUS examinations revealed complete resolution of the lesion. We believe that this tumor is a late metastasis to the contralateral seminal vesicle. More >

Richard D. Sowery, D. Robert Siemens

Canadian Journal of Urology, Vol.11, No.5, pp. 2407-2410, 2004

Abstract Objective: To characterize tumor growth of patients managed conservatively for renal cell carcinoma.
Methods: Patients electing conservative management of radiographically determined renal cell carcinomas were referred to a surveillance database. Exclusion criteria consisted of locally advanced disease (>T2) and those with metastatic disease. Clinical follow-up included renal imaging with ultrasound or computed tomography at least every 6 months.
Results: Twenty-two patients were originally managed conservatively, two of whom subsequently underwent nephrectomy because of rapid tumor growth. Mean follow-up was 26 months. Mean tumor volume and diameter at presentation was 62.4 cc and 4.08 cm respectively. Overall tumor growth More >

Jeffrey S. Montgomery¹, Brent K. Hollenbeck¹, Peter C. Fisher¹, Hedwig S. Murphy^2,4, Willie Underwood, III^1,3

Canadian Journal of Urology, Vol.11, No.5, pp. 2393-2395, 2004

Abstract Scrotal masses are common findings on genitourinary exam. The majority of these masses are benign and can be identified via history and physical exam alone. Question as to the origin of these masses merits additional evaluation that typically consists of an imaging study (e.g., ultrasound) and possibly serum tumor markers (e.g., HCG and AFP). In the end, surgical exploration may be necessary. Herein, the authors describe a rare case of benign paratesticular Schwannoma and discuss the clinical presentation and treatment of scrotal masses. More >

David C. Horger¹, Nabil K. Bissada², Nancy S. Curry³, Uzair B. Chaudhary⁴

Canadian Journal of Urology, Vol.11, No.6, pp. 2467-2469, 2004

Abstract The occurrence of an isolated late recurrence of renal cell carcinoma within the inferior vena cava (IVC) is a rare event. We present a case of a 55-year-old patient with recurrence in the IVC more than 3 years following her initial nephrectomy. The asymptomatic presentation of this patient with recurrent disease emphasizes the importance of close, long-term surveillance. More >

Nabeel Al-Brahim¹, Salem Alowami¹, Ian Davis², Dean Daya¹

Canadian Journal of Urology, Vol.11, No.6, pp. 2463-2466, 2004

Abstract An 83- year-old male presented with intermittent hematuria and obstructive symptoms. A CT scan of the abdomen and pelvis showed diffuse thickening of the urinary bladder and a large 10 cm liver mass. Histopathological examination of bladder biopsy demonstrated two distinct lesions. The surface showed non-invasive urothelial carcinoma and the submucosa demonstrated metastatic hepatocellular carcinoma showing bile pigment and expressed Hep Par 1 and CD10. To the best of our knowledge, this is the first case report of synchronous transitional cell carcinoma and metastatic hepatocellular carcinoma of the urinary bladder. More >

W. Kassouf, S. Binsaleh, D. D. Cohen, S. Carrier

Canadian Journal of Urology, Vol.11, No.6, pp. 2461-2462, 2004

Abstract We report a case of collecting duct carcinoma presenting as pyelonephritis with hypercalcemia and metastasis to the ovary. Case management and literature review being presented. More >

Neslihan Bukan¹, Sinan Sözen², Ugur Coskun³, Banu Sancak¹, Nazan Günel³, Ibrahim Bozkırlı², Çagrı Senocak²

European Cytokine Network, Vol.14, No.3, pp. 163-167, 2003

Abstract Background: Both interleukin-18 and nitric oxide are multifunctional molecules that are involved in the different steps of carcinogenesis.
Methods: In the present study, we measured serum interleukin-18 and nitric oxide activity in 51 bladder cancer patients with different tumor stage and grade, and in 8 healthy controls. Serum nitrite-nitrate levels were measured as an index of nitric oxide generation.
Results: Serum interleukin-18 levels were significantly higher in bladder cancer patients when compared to the control subjects (p > 0.05). Serum interleukin-18 levels were found to be higher in patients with Ta stage than patients with T1 More >

Olivier Toutirais¹, Patricia Chartier¹, Damien Dubois¹, Françoise Bouet¹, Jean Lévêque¹, Véronique Catros-Quemener¹, Noëlle Genetet¹

European Cytokine Network, Vol.14, No.4, pp. 246-255, 2003

Abstract Tumors could use several mechanisms to coexist with the host’s immune system or to protect themselves from an immune response. Thus, insufficient expression of cell surface molecules on tumor cells, which are important for T cell recognition or activation, could lead to induction of a state of tolerance. Tumor cells could also produce cytokines that would inhibit the immune response and allow tumor progression. Here, we studied, in vitro, the cell surface expression of immunologically important molecules in seven ovarian carcinoma (OVCA) cell lines and the constitutive expression of cytokines. All OVCA cell lines expressed… More >

L. Fazio, H. Razvi, J. L. Chin

Canadian Journal of Urology, Vol.10, No.3, pp. 1899-1904, 2003

Abstract Objective: Horseshoe kidney is one of the most common congenital anomalies of renal structure. Not infrequently, surgical management of both benign and malignant disorders is required in patients with horseshoe kidney due to the susceptibility to certain conditions. The literature suggests a greater proclivity to certain renal tumors with this anomaly. We present three cases of malignancy in horseshoe kidneys. The unique technical challenges presented by these cases and the surgical approaches are discussed.
Methods: Three patients with tumors involving horseshoe kidneys are reviewed and their management discussed.
Results: Two patients were found to have renal cell carcinoma… More >