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  • Open Access

    ARTICLE

    MicroRNA 125a-5p Inhibits Cell Proliferation and Induces Apoptosis in Hepatitis B Virus-Related Hepatocellular Carcinoma by Downregulation of ErbB3

    Guoyun Li, Wei Zhang, Li Gong, Xiaoping Huang

    Oncology Research, Vol.27, No.4, pp. 449-458, 2019, DOI:10.3727/096504017X15016337254623

    Abstract MicroRNAs, a class of endogenous noncoding RNAs, regulate gene expression at the posttranscriptional level and thus take part in multiple biological processes. An increasing number of miRNAs have been found to be dysregulated in hepatocellular carcinoma (HCC) and are involved in liver tumorigenesis. In this study, miR- 125a-5p was found to be obviously downregulated much more in hepatitis B virus (HBV)-related HCC. To investigate the effects of miR-125a-5p, miR-125a-5p was overexpressed in HepG2.2.15 and HepG3X cells. The findings have indicated that overexpression of miR-125a-5p dramatically inhibited cell proliferation and induced cell apoptosis. Furthermore, overexpression of More >

  • Open Access

    ARTICLE

    Overexpression of Pyruvate Dehydrogenase E1a Subunit Inhibits Warburg Effect and Induces Cell Apoptosis Through Mitochondria-Mediated Pathway in Hepatocellular Carcinoma

    Jihong Sun*†1, Jingjing Li†1, Zhixian Guo, Lu Sun†‡, Chenghui Juan§, Yubing Zhou, Hongli Gu, Yan Yu, Qiuyue Hu, Quancheng’ Kan, Zujiang Yu

    Oncology Research, Vol.27, No.4, pp. 407-417, 2019, DOI:10.3727/096504018X15180451872087

    Abstract Most cancers rely disproportionately on glycolysis for energy even in the presence of an adequate oxygen supply, a condition known as “aerobic glycolysis,” or the “Warburg effect.” Pyruvate dehydrogenase E1 subunit (PDHA1) is one of the main factors for the metabolic switch from oxidative phosphorylation (OXPHOS) to aerobic glycolysis and has been suggested to be closely associated with tumorigenesis. Here we observed that the PDHA1 protein was reduced in hepatocellular carcinoma (HCC) specimens by immunohistochemistry and Western blot, which was significantly associated with poor overall survival. To further analyze the function of PDHA1 in cancer More >

  • Open Access

    ARTICLE

    The Design and Implementation of a Multidimensional and Hierarchical Web Anomaly Detection System

    Jianfeng Guan*, Jiawei Li, Zhongbai Jiang

    Intelligent Automation & Soft Computing, Vol.25, No.1, pp. 131-141, 2019, DOI:10.31209/2018.100000050

    Abstract The traditional web anomaly detection systems face the challenges derived from the constantly evolving of the web malicious attacks, which therefore result in high false positive rate, poor adaptability, easy over-fitting, and high time complexity. Due to these limitations, we need a new anomaly detection system to satisfy the requirements of enterprise-level anomaly detection. There are lots of anomaly detection systems designed for different application domains. However, as for web anomaly detection, it has to describe the network accessing behaviours characters from as many dimensions as possible to improve the performance. In this paper we… More >

  • Open Access

    ARTICLE

    Surgical treatment of anomalous left main coronary artery with an intraconal course

    Richard D. Mainwaring, Frank L. Hanley

    Congenital Heart Disease, Vol.14, No.4, pp. 504-510, 2019, DOI:10.1111/chd.12826

    Abstract Objective: Anomalous left main coronary artery (LMCA) with an intraconal course is a relatively rare form of anomalous aortic origin of a coronary artery (AAOCA) from the wrong sinus of Valsalva. There is currently a paucity of information regarding this entity. The purpose of this article is to review our surgical experience with repair of anomalous LMCA with an intraconal course.
    Methods: This was a retrospective review of 12 patients with an anomalous LMCA and an intraconal course who underwent surgical repair. The median age at surgery was 15 years (range 2‐47). The seven oldest patients all… More >

  • Open Access

    ARTICLE

    Contemporary outcomes and mortality risks of Ebstein anomaly: A single-center experience in Thailand

    Varisara Pornprasertchai, Chodchanok Vijarnsorn, Supaluck Kanjanauthai, Paweena Chungsomprasong, Prakul Chanthong, Kritvikrom Durongpisitkul, Jarupim Soongswang

    Congenital Heart Disease, Vol.14, No.4, pp. 619-627, 2019, DOI:10.1111/chd.12759

    Abstract Background: The increasing number of patients with Ebstein anomaly (EA) surviving into adulthood implies improvements in the treatments for the complex lesion. We revisited the clinical outcomes of patients with EA to demonstrate their “real world” survival.
    Objectives: To identify the survival and predictors of mortality in patients with EA who underwent medical or surgical management in the present era.
    Methods: All patients who had EA with atrioventricular concordance between 1994 and 2016 were retrospectively reviewed. Baseline characteristics, initial echocardio‐ graphic findings, treatments, and outcomes were explored. The survival analysis was performed at the end of 2017. A… More >

  • Open Access

    ARTICLE

    Cerebrovascular accidents in Ebstein’s anomaly

    Nicholas Y. Tan1, Christine H. Attenhofer Jost1, Murray D. Polkinghorne1, Emily R. Vargas2, David O. Hodge2, Joseph A. Dearani3, Samuel J. Asirvatham1,4, Heidi M. Connolly1, Christopher J. McLeod1

    Congenital Heart Disease, Vol.14, No.6, pp. 1157-1165, 2019, DOI:10.1111/chd.12841

    Abstract Introduction: Mechanisms and risk factors for cerebrovascular accidents (CVAs) in Ebstein’s anomaly (EA) are not well understood; hence, we aimed to clarify these in a large cohort of EA patients.
    Methods: Patients with a confirmed diagnosis of EA were retrospectively reviewed. Baseline characteristics were compared between patients with and without a prior history of CVA using logistic regression modeling. Cox regression analysis was used to identify predictors of CVA following initial evaluation. CVA incidence from birth and following tricuspid valve surgery were estimated using the Kaplan‐Meier method.
    Results: Nine hundred sixty‐eight patients (median age 21.1 years, 41.5% male)… More >

  • Open Access

    ARTICLE

    The clinical characteristics of coronary artery fistula anomalies in children and adults: A 24‐year experience

    Kieu T. Huynh1, Vien T. Truong2,3, Tam N. M. Ngo3,4, Thao B. Dang5, Wojciech Mazur3, Eugene S. Chung3,6, Justin T. Tretter7, Dean J. Kereiakes3, Tuyen K. Le8, Vinh N. Pham1

    Congenital Heart Disease, Vol.14, No.5, pp. 772-777, 2019, DOI:10.1111/chd.12781

    Abstract Objectives: The aim of our work is to investigate the clinical characteristics of coro‐ nary artery fistula (CAF) anomalies in South Vietnam.
    Methods: This is a retrospective analysis of 119 patients with diagnosis of definite CAF between January 1992 and April 2016. The demographic, clinical, echocardio‐ graphic, and angiographic characteristics and management of CAF with short‐term outcomes are described.
    Results: The median age was 15 years (range, 1‐79 years), with 49 male (41%) and 70 female (59%). There were 77 symptomatic patients (64.7%) and 91 patients (76.5%) who presented with a murmur. The electrocardiogram was abnormal in 45.4%… More >

  • Open Access

    ARTICLE

    A Novel Probabilistic Hybrid Model to Detect Anomaly in Smart Homes

    Sasan Saqaeeyan1, Hamid Haj Seyyed Javadi1,2,*, Hossein Amirkhani1,3

    CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 815-834, 2019, DOI:10.32604/cmes.2019.07848

    Abstract Anomaly detection in smart homes provides support to enhance the health and safety of people who live alone. Compared to the previous studies done on this topic, less attention has been given to hybrid methods. This paper presents a two-steps hybrid probabilistic anomaly detection model in the smart home. First, it employs various algorithms with different characteristics to detect anomalies from sensory data. Then, it aggregates their results using a Bayesian network. In this Bayesian network, abnormal events are detected through calculating the probability of abnormality given anomaly detection results of base methods. Experimental evaluation More >

  • Open Access

    ARTICLE

    A Possible Reason About Origin of Singularity and Anomalous Dispersion in Peridynamics

    Xinfeng Wang1, Zaixing Huang1,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.2, pp. 385-398, 2019, DOI:10.32604/cmes.2019.06936

    Abstract In the benchmark problems of peridynamics, there are some eccentric results, for example, singularity of uniaxial tension and anomalous dispersion of wave. The reasons to give rise to these results are investigated. We calculated local tension and wave of an infinite rod after adding a divergence of local stress in the peridynamic motion equation. The acquired results verify that the singularity in the peridynamic solution of local tension problem and anomalous dispersion of peridynamic wave are all eliminated. Therefore, the anomalous features of some peridynamic solutions likely stem from the lack of local stress characterizing More >

  • Open Access

    ABSTRACT

    Matrix Stiffness Promotes Hepatoma Cell Glycolysis and Migration Through YAP-Mediated Mechanotransduction

    Qiuping Liu1, Guanbin Song1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 127-127, 2019, DOI:10.32604/mcb.2019.07105

    Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide. Increased matrix stiffness of extracellular matrix (ECM) is commonly associated with HCC. During tumour formation and expansion, increasing glucose metabolism is necessary for unrestricted growth of tumour cells. Yet, the correlation between matrix stiffness and glucose metabolism in the development of HCC remains unknown. In this study, we aim to investigate the effect of matrix stiffness on glucose metabolism and migration of MHCC97L and HepG2 hepatoma cells, and explore the mechanotransduction involved in this process. Polyacrylamide hydrogels with stiffness gradients of 6,… More >

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