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  • Open Access

    REVIEW

    Current status of gene therapy in melanoma treatment

    YONGLU WANG1,2,*, WEI YOU1, XUEMING LI3,4,*

    BIOCELL, Vol.44, No.2, pp. 167-174, 2020, DOI:10.32604/biocell.2020.09023 - 27 May 2020

    Abstract Melanoma is the deadliest type of skin cancer and which has a high ability of metastasis. Surgery is an effective method to treat I or II stage melanoma patients. However, there are few treatment options for metastatic melanoma. Gene therapy is one of the attractive options and is considered as the future direction for treating melanoma. This review mainly discusses the properties and challenges of the various gene therapies in melanoma, especially the delivery systems and gene targeting. More >

  • Open Access

    ARTICLE

    Impacts of Heat Flux Distribution, Sloping Magnetic Field and Magnetic Nanoparticles on the Natural Convective Flow Contained in a Square Cavity

    Latifa M. Al-Balushi, M. M. Rahman*

    FDMP-Fluid Dynamics & Materials Processing, Vol.16, No.3, pp. 441-463, 2020, DOI:10.32604/fdmp.2020.08551 - 25 May 2020

    Abstract In the present paper, the effect of the heat flux distribution on the natural convective flow inside a square cavity in the presence of a sloping magnetic field and magnetic nanoparticles is explored numerically. The nondimensional governing equations are solved in the framework of a finite element method implemented using the Galerkin approach. The role played by numerous model parameters in influencing the emerging thermal and concentration fields is examined; among them are: the location of the heat source and its lengthH*, the magnitude of the thermal Rayleigh number, the nanoparticles shape and volume fraction, and… More >

  • Open Access

    ARTICLE

    Exact Solution of Non-Newtonian Blood Flow with Nanoparticles through Porous Arteries: A Comparative Study

    Wafaa Alharbi1, Abdulrahman Aljohani1, Essam El-Zahar2, 3, *, Abdelhalim Ebaid1

    CMC-Computers, Materials & Continua, Vol.63, No.3, pp. 1143-1157, 2020, DOI:10.32604/cmc.2020.08875 - 30 April 2020

    Abstract In this paper, the mathematical model describing the third-grade nonNewtonian blood flow suspended with nanoparticles through porous arteries is exactly solved. The present physical model was solved in the research literature via the optimal homotopy analysis method and the collocation method, where the obtained solution was compared with the numerical fourth-order Runge-Kutta solution. However, the present paper only introduces a new approach to obtain the exact solution of the concerned system and implements such exact solution as a reference to validate the published approximate solutions. Several remarks on the previously published results are observed and… More >

  • Open Access

    ARTICLE

    Mycogenic Silver Nanoparticles From Endophytic Trichoderma atroviride with Antimicrobial Activity

    Ahmed Abdel-Azeem1,*, Amr A. Nada2,3, Anthonia O’Donovan4, Vijay Kumar Thakur5, Amr Elkelish6

    Journal of Renewable Materials, Vol.8, No.2, pp. 171-185, 2020, DOI:10.32604/jrm.2020.08960 - 01 February 2020

    Abstract There is an increasing interest in developing nanoparticles with diverse biologic activities. To this end, we prepared 10 to 15 nm silver nanoparticles (AgNP) from native isolates of Trichoderma atroviride. Within this study, endophytic fungi hosted four medicinal plants in Saint Katherine Protectorate, South Sinai, Egypt have been isolated by surface sterilization technique on four isolation media. Ten species, based on their frequency of occurrence, out of twenty recovered taxa were tested for their capability to synthesize extracellular AgNPs. Trichoderma atroviride hosted Chiliadenus montanus was found to be the best candidate for the production of mycogenic AgNPs among… More >

  • Open Access

    ARTICLE

    Green Synthesis of Silver Nanoparticles from Abronia villosa as an Alternative to Control of Pathogenic Microorganisms

    Ali Abdelmoteleb1, Benjamin Valdez-Salas2, Ernesto Beltran-Partida2, Daniel Gonzalez-Mendoza3,*

    Journal of Renewable Materials, Vol.8, No.1, pp. 69-78, 2020, DOI:10.32604/jrm.2020.08334 - 01 January 2020

    Abstract The aim of this study was to evaluate the antibacterial and antifungal activities of eco-friendly synthesized silver nanoparticles. The silver nanoparticles were synthesized by biological method using aqueous extract of Abronia villosa. Synthesis of silver nanoparticles was confirmed by color change and characterized using UV-visible spectroscopy, scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDX), dynamic light scattering (DLS), and zeta potential analysis. The SEM analysis revealed the presence of spherical silver nanoparticles of the size range 21 to 33 nm. Synthesized silver nanoparticles were used to evaluate their antibacterial effects at different concentrations (25, 50, More >

  • Open Access

    ARTICLE

    Mechanical and Biological Properties of Chitosan Nanocomposite Films: Effects of POSS nanoparticles

    R. VENKATESAN*, S. R. DARSON IMMANUEL JOHN, N. RAJESWARI

    Journal of Polymer Materials, Vol.36, No.3, pp. 261-273, 2019, DOI:10.32381/JPM.2019.36.03.6

    Abstract Nanocomposite films of chitosan (CH) incorporated with different wt. % of the polyoligomericsilsesquioxane (POSS) were prepared by solution casting. The thermal, mechanical, morphological and antimicrobial properties of the nanocomposites were examined. TGA analyses of the nanocomposites indicate that the filler enables the enhancement of thermal stability of chitosan. The tensile strength of the nanocomposite films is enhanced (10.9 MPa for neat chitosan to 24.0MPa for 5wt. % filled chitosan) by the addition of POSS while the elongation at break is reduced. The nanocomposite films exhibited excellent antimicrobial activity against both gram positive and gram negative More >

  • Open Access

    ARTICLE

    MAGNETO-CONVECTION OF ALUMINA - WATER NANOFLUID WITHIN THIN HORIZONTAL LAYERS USING THE REVISED GENERALIZED BUONGIORNO'S MODEL

    A.Wakifa,* , Z. Boulahiaa, A. Amineb , I.L. Animasaunc , M. I. Afridid, M. Qasimd , R. Sehaquia

    Frontiers in Heat and Mass Transfer, Vol.12, pp. 1-15, 2019, DOI:10.5098/hmt.12.3

    Abstract The significance of an externally applied magnetic field and an imposed negative temperature gradient on the onset of natural convection in a thin horizontal layer of alumina-water nanofluid for various sizes of spherical alumina nanoparticles (e.g., 30 More >

  • Open Access

    ARTICLE

    Improving the Sound Absorption Properties of Flexible Polyurethane (PU) Foam using Nanofibers and Nanoparticles

    Roohalah Hajizadeh1, Ali Khavanin2,*, Mohammad Barmar3, Ahmad Jonidi Jafari4, Somayeh Farhang Dehghan5

    Sound & Vibration, Vol.53, No.5, pp. 207-222, 2019, DOI:10.32604/sv.2019.06523

    Abstract Polyurethane foam as the most well-known absorbent materials has a suitable absorption coefficient only within a limited frequency range. The aim of this study was to improve the sound absorption coefficient of flexible polyurethane (PU) foam within the range of various frequencies using clay nanoparticles, polyacrylonitrile nanofibers, and polyvinylidene fluoride nanofibers. The response surface method was used to determine the effect of addition of nanofi- bers of PAN and PVDF, addition of clay nanoparticles, absorbent thickness, and air gap on the sound absorption coefficient of flexible polyurethane foam (PU) across different frequency ranges. The absorption… More >

  • Open Access

    ABSTRACT

    Immune Cells Migrating through the Brain Endothelia Junctions Served as Shuttles for Nanoparticles Delivery to Glioblastoma

    Gloria B. Kim1,†, Qiong Wei2,†, Virginia Aragon-Sanabria1, Sulin Zhang2, Jian Yang1, Cheng Dong1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 15-15, 2019, DOI:10.32604/mcb.2019.07137

    Abstract Most cells survive and grow by attaching and spreading on a substrate. They generate internal tension that contracts the cell body and thus exert tractions on the underlying substrate through focal adhesions. Traction force also plays a critical role in many biological processes, such as inflammation, metastasis, and angiogenesis. Thus, measuring the cell traction force provides valuable information on understanding the underlying mechanism of these biological processes. Here, a traction force microscopy (TFM) method using super thin hydrogels composed of immobilized fluorescent beads was utilized to quantify the mechanical forces generated during the transmigration of… More >

  • Open Access

    ARTICLE

    Green Synthesis of Bimetallic Nanoparticles From Prosopis juliflora (Sw) DC., and Its Effect Against Cotton Mealybug, Phenacoccus solenopsis (Hemiptera: Pseudococcidae)

    V. Mendez-Trujillo1, B. Valdez-Salas2, M. Carrillo-Beltran2, M. A. Curiel-Alvarez2, O. Tzintzun-Camacho3, C. Ceceña-Duran3 and D. Gonzalez-Mendoza3,*

    Phyton-International Journal of Experimental Botany, Vol.88, No.3, pp. 269-275, 2019, DOI:10.32604/phyton.2019.07316

    Abstract Phenacoccus solenopsis has been recognized as an aggressively invasive species on cotton plants in different countries. This study was conducted to investigate the effect of green synthesized Cu/Zn-nanoparticles using aqueous leaf extract of Prosopis juliflora (mezquite) against P. solenopsis. The scanning electron microscope (SEM) showed bimetallic nanoparticles of Cu/Zn-NPs with spherical shape with varying size of 74.33 nm to 59.46 nm. More than 30% mortality of P. solenopsis was observed with Cu/Zn-nanoparticles (100 ppm) at 96 hours after treatment. Negligible mortality of P. solenopsis was recorded with Cu/Zn solution (100 ppm) and aqueous P. juliflora More >

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