Yizhao Huang¹, Nannan Li², Deya Wang⁴, Jian Du¹, Weitang Liu³, Jinxin Wang^3,*, Wei Li^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.4, pp. 761-772, 2022, DOI:10.32604/phyton.2022.018462 - 09 December 2021

Abstract Beckmannia syzigachne is a noxious weed for rice-wheat rotations in China. The B. syzigachne (AH-02) population evolved metabolic resistance to fenoxaprop-P-ethyl and mesosulfuron-methyl. To investigate the function of GT73C1 in this population, the GT73C1 gene was amplified by reverse transcription-polymerase chain reaction, and the sequence was 100% consistent with the transcriptome data. Its phylogenetic tree was displayed and annotated using FigTree v1.4.4. The plant overexpression vector of GT73C1 gene was constructed and used to transform Brachypodium distachyon plants. Furthermore, the expression of GT73C1 was significantly induced by fenoxaprop-P-ethyl and mesosulfuron-methyl, which was consistent with the findings from the whole plant More >

YI DONG¹, LIANBO ZHANG², XIN GUAN³, TAO LIU¹, LIMIN ZHOU^1,*

Oncology Research, Vol.29, No.4, pp. 291-303, 2021, DOI:10.32604/or.2022.025172 - 31 August 2022

Abstract Increasing numbers of long noncoding RNAs (lncRNAs) are implicated in breast cancer oncogenicity. However, the contribution of LINC02568 toward breast cancer progression remains unclear and requires further investigation. Herein, we evaluated LINC02568 expression in breast cancer and clarified its effect on disease malignancy. We also investigated the mechanisms underlying the pro-oncogenic role of LINC02568. Consequently, LINC02568 was upregulated in breast cancer samples, with a notable association with worse overall survival. Functionally, depleted LINC02568 suppressed cell proliferation, colony formation, and metastasis, whereas LINC02568 overexpression exerted the opposite effects. Our mechanistic investigations suggested that LINC02568 was physically More >

Elda A. Flores-Contreras¹, Everardo González-González^2,3, Ana I. Zarazúa-Niño¹, Elsa N. Garza-Treviño¹, Natalia Martínez-Acuña¹, Viviana C. Zomosa-Signoret⁴, Román Vidaltamayo⁴, Gerardo E. Muñoz-Maldonado⁵, Raquel Garza-Guajardo⁶, Manuel de J. García-Solís⁷, Alejandro Abarca-Blanco³, Ana M. G. Rivas-Estilla¹, Carlos Córdova-Fletes^1,*

Oncologie, Vol.23, No.3, pp. 373-392, 2021, DOI:10.32604/oncologie.2021.017786 - 26 September 2021

Abstract Breast cancer (BC) is one of the leading causes of death in women worldwide. A major challenge in BC is chemoresistance, which is often modulated by epigenetic regulators such as long non-coding RNAs (lncRNAs). Because these regulator lncRNAs may play diverse roles, determining their specific pathways and/or functions is crucial to identify possible biomarkers and/or therapeutic targets for BC. In this study, we used gene expression microarrays in order to identify lncRNAs related to the BC biology. We found, among six differentially expressed (DE) lncRNAs, that the expression of lnc-ERP44-3:6 was consistently down-regulated in all breast… More >

ANZANA PARVIN^1,3, BANG-HONG WEI¹, SHUANG-LI HAO¹, WAN-XI YANG^1,*, FU-QING TAN^1,2,*

BIOCELL, Vol.45, No.5, pp. 1369-1391, 2021, DOI:10.32604/biocell.2021.016654 - 12 July 2021

Abstract Mitotic kinesin KIFC1 plays critical roles in mitosis by regulating the spindle length, pole formation, and known for clustering extra centrosomes in cancer cells. Centrosome clustering is associated with the survival of cancer cells, but this phenomenon remains obscure in prostate cancer (PCa). The present study demonstrated that PCa cells showed centrosome amplification and clustering during interphase and mitosis, respectively. KIFC1 is highly expressed in PCa cells and tumor tissues of prostatic adenocarcinoma (PAC) patients. Up-regulation of KIFC1 facilitated the PCa cell survival in vitro by ensuring bipolar mitosis through clustering the multiple centrosomes, suggesting centrosome… More >

CHUNKUN FAN, YONGPENG ZHANG, CHUNBAO YANG, YAWEI TANG, JI QU, BU JIE, DEJI QUZHEN, LIYUN GAO^*

BIOCELL, Vol.45, No.4, pp. 1121-1135, 2021, DOI:10.32604/biocell.2021.014336 - 22 April 2021

Abstract Salinity is a serious challenge for agriculture production by limiting the arable land. Rice is a major staple food crop but very sensitive to salt stress. In this study, we used Arabidopsis for the functional characterization of a rice F-box gene LOC_Os04g48270 (OsPP12-A13) under salinity stress. OsPP12-A13 is a nuclear-localized protein that is strongly upregulated under salinity stress in rice and showed the highest expression in the stem, followed by roots and leaves. Two types of transgenic lines for OsPP12-A13 were generated, including constitutive tissue over-expression using the CaMV35S promoter and phloem specific over-expression using the pSUC2 promoter.… More >

Shiyang Li^1,#, Xue-Ao Liu^2,#, Lizi Zhao², Huiqing Huang³, Bei Li², Zhizhong Song², Meixia Liang², Hongxia Zhang^2,3, Limin Wang^2,*, Shenglin Zhou^1,*

Phyton-International Journal of Experimental Botany, Vol.90, No.3, pp. 761-772, 2021, DOI:10.32604/phyton.2021.016314 - 30 March 2021

Abstract Seven in absentia (SINA) family proteins play a central role in plant growth, development and resistance to abiotic stress. However, their biological function in plant response to cold stress is still largely unknown. In this work, a seven in absentia gene IbSINA5 was isolated from sweet potato. Quantitative real-time polymerase chain reaction (qRT-PCR) analyses demonstrated that IbSINA5 was ubiquitously expressed in various tissues and organs of sweet potato, with a predominant expression in fibrous roots, and was remarkably induced by cold, drought and salt stresses. Subcellular localization assays revealed that IbSINA5-GFP fusion protein was mainly localized in cytoplasm… More >

Huasong Liu^*1, Jun Zhang^*1, Xiangyu Luo^*, Min Zeng^*, Liqiang Xu^*, Qunxian Zhang^*, Hua Liu^*, Jialong Guo^*, Lanlan Xu^†

Oncology Research, Vol.28, No.1, pp. 65-73, 2020, DOI:10.3727/096504019X15656904013079

Abstract Emerging evidence has demonstrated that long noncoding RNAs (lncRNAs) mediate the development of esophageal squamous cell carcinoma (ESCC) via various pathophysiological pathways. This study explored the impact of the lncRNA FOXD2-AS1 on cisplatin resistance in ESCC and its possible mechanisms. Upregulation of FOXD2-AS was detected in patients with ESCC and ESCC cells that are resistant to cisplatin. In an in vitro assay, knockdown of FOXD2-AS1 noticeably inhibited cell invasion and growth, triggered cell death, and repressed the stimulation of the Akt/mTOR axis in cisplatin-resistant ESCC cells (TE-1/DDP). Conversely, the overexpression of FOXD2-AS1 remarkably increased cell More >

Youwei Zhang^*, Bi Chen^†, Yongsheng Wang^‡, Qi Zhao^‡, Weijun Wu^§, Peiying Zhang^*, Liyun Miao^‡, Sanyuan Sun^*

Oncology Research, Vol.27, No.7, pp. 751-761, 2019, DOI:10.3727/096504018X15372657298381

Abstract Acquired resistance remains a key challenge in epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitors (TKIs) therapy in lung adenocarcinoma (LUAD). Recent studies have shown that Notch signaling is associated with drug resistance. However, its role and possible mechanisms in EGFR-TKI resistance are not yet clear. In our study, we found that among four members of NOTCH1–4, only NOTCH3 was upregulated in LUAD tissues and TKI-resistant cell line (HCC827GR6). Knockdown of NOTCH3 by siRNA significantly inhibited proliferative ability, and decreased colony and sphere formation in HCC827GR6 cells. Then miR-150 was identified as a posttranscriptional regulator of… More >

Hao Chen, Yi Zhang, Hai Su, Hui Shi, Qijiang Xiong, Zulu Su

Oncology Research, Vol.27, No.3, pp. 325-334, 2019, DOI:10.3727/096504018X15251282086836

Abstract It is well known that activating transcription factor 4 (ATF4) expression is closely associated with progression of many cancers. We found that miR-1283 could directly target ATF4. However, the precise mechanisms of miR-1283 in glioma have not been well clarified. Our study aimed to explore the interaction between ATF4 and miR-1283 in glioma. In this study, we found that the level of miR-1283 was dramatically decreased in glioma tissues and cell lines, the expression of ATF4 was significantly increased, and the low level of miR-1283 was closely associated with high expression of ATF4 in glioma More >

Xiaoying Han^*1, Jing Yang^†1, Dong Li^‡, Zewei Guo^§

Oncology Research, Vol.27, No.5, pp. 533-540, 2019, DOI:10.3727/096504018X15199489058224

Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. Although the mechanisms of HCC progression are not well understood, recent studies demonstrated the potential contribution of uric acid transporter SLC2A9 to tumor suppression. However, the roles and underlying mechanisms are still unknown. We aimed to study the roles and mechanisms of SLC2A9 in HCC. The present study showed that SLC2A9 expression was decreased in human HCC tissues and cell lines. In addition, overexpression of SLC2A9 inhibited HCC cell proliferation. SCL2A9 induced HCC cell apoptosis by inhibiting the expression of caspase 3. Our More >