Wang QL, DH Liu, JY Yue

Phyton-International Journal of Experimental Botany, Vol.85, pp. 270-282, 2016, DOI:10.32604/phyton.2016.85.270

Abstract This study aimed to determine the effects of different Cd concentrations (0, 1, 10, 100, and 300 μM CdCl₂) on Allium plantlets. To achieve this goal, we examined the (1) dynamics of Cd²⁺ flux in the rhizosphere, (2) partitioning of Cd between roots and leaves, (3) formation of reactive oxygen species (ROS), (4) levels of H₂O₂ and chlorophyll, and (5) translocation of several macro- and micronutrients. A strong net Cd²⁺ influx was observed in the root apex after exposure to 100 μM Cd for 24 h. Exposure to either 1 or 10 μM Cd for 96 h More >

Natacha E PILONI, Elizabeth ROBELLO, Julián G BONETTO, Susana PUNTARULO^*

BIOCELL, Vol.40, No.1, pp. 39-42, 2016, DOI:10.32604/biocell.2016.40.039

Abstract Fe is essential for human life because it constitutes the required cofactor for proteins of diverse biological functions. However, the development of oxidative stress by exposure to excessive Fe, share signaling pathways with other treatments including activation of redox-sensitive factors. This study was focused on the comparison on the effects of Fe in the brain and other organs in vivo. The oxidative effects triggered by Fe overload strongly depend not only on the administration protocol, but also on the Fe-compound used, and the studied organ. In both the liver and the brain, Fe content drastically… More >

Gabriela MALANGA, Paula Mariela GONZÁLEZ, Juan Manuel OSTERA, Susana PUNTARULO^*

BIOCELL, Vol.40, No.1, pp. 35-38, 2016, DOI:10.32604/biocell.2016.40.035

Abstract The harmful effects of the reactive species may be due to the increase in their steady state concentration either by the enhancement of their production rates and/or the decrease of their consumption rate by antioxidant activity. The ascorbyl radical (A^• ) can be considered as a final product of radical oxidative transformations of ascorbate (AH^-). The ratio A^• content/AH^- content (A^• /AH^-) has been widely used as an interesting tool to estimate mild to moderate oxidative transformations, providing a quick and simple method of diagnosis of stress in the hydrophilic cellular medium. The aim of this work was More >

Marcelo HERNANDO¹, Christian HOUGHTON¹, Leda GIANNUZZI², Bernd KROCK³, Darío ANDRINOLO², Gabriela MALANGA^4,*

BIOCELL, Vol.40, No.1, pp. 23-26, 2016, DOI:10.32604/biocell.2016.40.023

Abstract Cyanobacteria are phototrophic organisms with great ecological and economical importance. Species of the genus Microcystis are known for their potential ability to synthesize toxins, notably microcystins. There is a growing interest in the evaluation of oxidative stress in relation to the impact of global climate change on natural ecosystems in different trophic levels. Several studies have focused on the analysis of organismal responses to mitigate the damage by controlling the generation of reactive oxygen species. Variations in environmental factors caused by climate change generate a situation of oxidative damage in Microcystis aeruginosa as a direct or indirect… More >

Nidia FERRAROTTI¹, Rosario MUSACCO-SEBIO², Christian SAPORITO-MAGRIÑÁ², Juan Manuel ACOSTA², Marisa REPETTO^{2 *}

BIOCELL, Vol.40, No.1, pp. 19-22, 2016, DOI:10.32604/biocell.2016.40.019

Abstract The objective of this work was to study the in vivo time course of biochemical processes of oxidative damage in the brain of Sprague-Dawley rats that received an acute overload of the redox active metals iron (Fe) and copper (Cu), and the redox inactive cobalt (Co) and nickel (Ni). Oxidative stress indicators (phospholipid and protein oxidation), glutathione (GSH), antioxidant enzymes and NADPH oxidase activities, and the plasma inflammatory cytokine (IL-6) were measured. The results showed that in brain oxidative mechanisms for both sets of metal are different, however in both cases are irreversible. The mechanism… More >

Jimena P. CABILLA, Sonia A. RONCHETTI, Beatriz H. DUVILANSKI^*

BIOCELL, Vol.40, No.1, pp. 15-18, 2016, DOI:10.32604/biocell.2016.40.015

Abstract Environmental contamination with some metalloids and heavy metals (M/HM) raises concern due to well known adverse effects on health. Among these pollutants, chromium VI (Cr VI), cadmium (Cd) and arsenic (As) are frequently present as a result of natural sources or due to industrial activities. They are able to easily enter the organism and negatively affect many organs and systems. In vivo (exposure to Cr VI, Cd or As through drinking water) and in vitro experiments (primary pituitary cell cultures) were performed in male Wistar rats to address their actions on hypothalamus-pituitary axis. All the… More >

Bustingorri C, K Balestrasse, RS Lavado

Phyton-International Journal of Experimental Botany, Vol.84, No.2, pp. 407-416, 2015, DOI:10.32604/phyton.2015.84.407

Abstract Arsenic (As) and Fluoride (F) are present in many soils, affecting crops and posing risks in the food chain. We performed pot experiments on spiked soils enriched in these elements either individually or simultaneously, over a wide range of concentrations. Soybean biomass production, grain yield, As and F accumulation and distribution within the plant, and the antioxidant response to these stresses were analyzed. Arsenic was more toxic than F. At As levels >35 mg/kg and F levels >375 mg/kg, yield loss reached 60% and 30%, respectively. At the highest dose of As plants died within More >

Berengere PAPEGAY^{1, *}, Michaela STADLER¹, Vincent Nuyens¹, Isabelle SALMON², Veronique KRUYS³, Jean G. BOOGAERTS¹

BIOCELL, Vol.38, No.1, pp. 25-32, 2014, DOI:10.32604/biocell.2014.38.025

Abstract Ischemia-reperfusion injury is a determinant in liver injury occurring during surgery, ischemic states and multiple organ failure. The pre-existing nutritional status of the liver, i.e., fasting, might contribute to the extent of tissue injury. This study investigated whether alanine, an amino acid precursor of glucose, could protect ex vivo perfused livers of fasting rats from reperfusion injury. The portal vein was cannulated, the liver removed and perfused in a closed ex vivo system. Isolated livers were perfused either with glucose 1 g/L and 10 g/L, or with equal concentrations of alanine (n = 10 in… More >

Recep Bentli¹, Osman Ciftci², Asli Cetin³, Merve Unlu², Nese Basak², Mahmut Çay⁴

European Cytokine Network, Vol.24, No.2, pp. 91-96, 2013, DOI:10.1684/ecn.2013.0337

Abstract The objective of the current study was to investigate the protective effects of hesperidin against oxidative stress, altered cytokines levels and histological changes in rats induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Rats were divided randomly into four equal groups (Control, TCDD, hesperidin and TCDD+hesperidin). TCDD and hesperidin were given by gavage, dissolved in corn oil at doses of 2 μ/kg/week and 50 mg/kg/day respectively. The blood and tissue samples were taken from all rats on the 60^th day, to be analyzed for the determination of oxidative stress, histological changes and cytokine levels. The results indicated that hesperidin prevented More >

Nehal M. Elsherbiny¹, Khaled H. Abd El Galil², Mahmoud M. Gabr³, Mohammed M. Al-Gayyar¹, Laila A. Eissa¹, Mamdouh M. El-Shishtawy¹

European Cytokine Network, Vol.23, No.3, pp. 78-86, 2012, DOI:10.1684/ecn.2012.0309

Abstract Diabetic nephropathy (DN) remains the most common cause of end-stage renal disease. Although, adenosine acts as a local modulator with a cytoprotective function, extracellular adenosine usually disappears quickly due to a rapid uptake into adjacent cells. Therefore, we investigated the effect of 5' -(N-ethylcarboxamido)- adenosine (NECA), a stable, nonselective adenosine receptor agonist, on diabetes-induced increases in inflammatory cytokines and adhesion molecules. The enhancement of adenosine receptor action by NECA was examined in the renal tissues of rats with streptozotocin-induced diabetes. Daily i.p. injections of NECA at 0.3 mg/kg/day were given to rats, over a two-week… More >