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  • Open Access

    ARTICLE

    Cell proliferation of the ileum intestinal mucosa of diabetic rats treated with ascorbic acid

    JACQUELINE NELISIS ZANONI, RENATA VIRGINIA FERNANDES PEREIRA

    BIOCELL, Vol.32, No.2, pp. 163-168, 2008, DOI:10.32604/biocell.2008.32.163

    Abstract The objective of this work was to evaluate the effect of the ascorbic acid supplementation on the cellular proliferation on the ileum mucosa of diabetic rats. Fifteen 90-days rats were divided in the groups: control, diabetic and diabetic supplemented with ascorbic acid (DA). Two hours prior the sacrifice, they were injected with Vincristin. Semi-seriate histological cuts stained with HE were accomplished. About 2500 crypt cells from the intestinal mucosa were counted in order to obtain the metaphasic indexes. The height and depth of 30 villi and 30 crypts were measured for each animal, respectively. The… More >

  • Open Access

    ARTICLE

    Role of Shear Stress Direction in Endothelial Mechanotransduction

    Shu Chien*

    Molecular & Cellular Biomechanics, Vol.5, No.1, pp. 1-8, 2008, DOI:10.3970/mcb.2008.005.001

    Abstract Fluid shear stress due to blood flow can modulate functions of endothelial cells (ECs) in blood vessels by activating mechano-sensors, signaling pathways, and gene and protein expressions. Laminar shear stress with a definite forward direction causes transient activations of many genes that are atherogenic, followed by their down-regulation; laminar shear stress also up-regulates genes that inhibit EC growth. In contrast, disturbed flow patterns with little forward direction cause sustained activations of these atherogenic genes and enhancements of EC mitosis and apoptosis. In straight parts of the arterial tree, laminar shear stress with a definite forward More >

  • Open Access

    ARTICLE

    Cell-cell communication between mouse mammary epithelial cells and 3T3-L1 preadipocytes: Effect on triglyceride accumulation and cell proliferation

    VANINA L. JULIANELLI1 , LILIANA N. GUERRA*1, JUAN C. CALVO*1,2

    BIOCELL, Vol.31, No.2, pp. 237-245, 2007, DOI:10.32604/biocell.2007.31.237

    Abstract Interaction between parenchyma and stroma is essential for organogenesis, morphogenesis, and differentiation. Mammary gland has being the chosen model for developmental biologist because the most striking changes in morphology and function take place after birth. We have demonstrated a regulation of triglyceride accumulation by protein factors synthesized by normal mouse mammary gland epithelial cells (NMMG), acting on a cell line, 3T3-L1, long used as a model for adipogenesis. In this paper, we demonstrate that this inhibitory effect seems to be shared by other cells of epithelial origin but not by other cell types. We found More >

  • Open Access

    ARTICLE

    Regulation of Cyclic Longitudinal Mechanical Stretch on Proliferation of Human Bone Marrow Mesenchymal Stem Cells

    Guanbin Song∗,†,‡, Yang Ju∗,†,§, Hitoshi Soyama*, Toshiro Ohashi, Masaaki Sato

    Molecular & Cellular Biomechanics, Vol.4, No.4, pp. 201-210, 2007, DOI:10.3970/mcb.2007.004.201

    Abstract Mechanical stimulation is critical to both physiological and pathological states of living cells. Although a great deal of research has been done on biological and biochemical regulation of the behavior of bone marrow mesenchymal stem cells (MSCs), the influence of biomechanical factors on their behavior is still not fully documented. In this study, we investigated the modulation of mechanical stretch magnitude, frequency, and duration on the human marrow mesenchymal stem cells (hMSCs) proliferation by an in vitro model system using a mechanical stretch loading apparatus, and optimized the stretch regime for the proliferation of hMSCs.… More >

  • Open Access

    ARTICLE

    Airway Smooth Muscle Proliferation and Mechanics: Effects of AMP Kinase Agonists

    Anat Ratnovsky∗,†, Matthew Mellema*, Steven S. An∗,‡, Jeffrey J. Fredberg*, Stephanie A. Shore*

    Molecular & Cellular Biomechanics, Vol.4, No.3, pp. 143-158, 2007, DOI:10.3970/mcb.2007.004.143

    Abstract Obesity is a risk factor for asthma. The purpose of this study was to determine whether metformin, an agent used in the treatment of an obesity-related condition (type II diabetes), might have therapeutic potential for modifying the effects of obesity on airway smooth muscle (ASM) function. Metformin acts via activation of AMP-activated protein kinase (AMPK), a cellular sensor of energy status. In cultured murine ASM cells, metformin (0.2--2 mM) caused a dose-dependent inhibition of cell proliferation induced by PDGF (10-8 M) and serotonin (10-4 M). Another AMPK activator, 5-aminoimidazole-4-carboxamide-1-ß-D-riboruranoside (AICAR), also inhibited PDGF-induced proliferation. Furthermore, cells More >

  • Open Access

    ARTICLE

    Cellular Mechanical Stress Gradient Regulates Cell Proliferation and Differentiation Patterns

    B. Li1, F. Li1, H-X. Li1, X-C. Xu1, M. Szczodry1, Z-C. Yang1, J-S. Lin2, J. H-C. Wang1, *

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 225-227, 2006, DOI:10.32604/mcb.2006.003.225

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Quantum Dot Labeling of Stem Cells during Proliferation and Differentiation

    E. K. Moioli1, B. Shah1, P. A. Clark1, M. Stroscio1, J. J. Mao1

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 153-155, 2006, DOI:10.32604/mcb.2006.003.153

    Abstract This article has no abstract. More >

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