Brian D. M. Blew, Luke M. Fazio, Kenneth Pace, R. John D’A. Honey

Canadian Journal of Urology, Vol.12, No.6, pp. 2891-2894, 2005

Abstract Classically, surgical options for very large prostate glands, not amenable to transurethral resection, include suprapubic or retropubic simple prostatectomy and Holmium laser enucleation of the prostate (HoLEP). We present a case managed with a laparoscopic simple prostatectomy. Technical considerations are discussed as well as possible advantages of this approach including decreased blood loss, faster patient recovery and improved visualization. More >

J. Curtis Nickel¹, Fred Saad²

Canadian Journal of Urology, Vol.11, No.2, pp. 2186-2193, 2004

Abstract The 2003 American Urological Association (AUA) guideline on management of benign prostatic hyperplasia (BPH) was released at the AUA annual meeting in Chicago, April 2003 and the diagnosis and treatment recommendations were published later in 2003. It is likely that the 2003 AUA guideline on the management of BPH will have a profound effect on clinical urologic practice in the USA, but its influence on Canadian urological practice will be different because of our socialized medical system, manpower issues, availability of expensive technology and our unique Canadian perspective. The authors review the 2003 AUA guideline More >

Heather McDonald¹, Margaret Hux¹, Marc Brisson², Lisa Bernard¹, J. Curtis Nickel³

Canadian Journal of Urology, Vol.11, No.4, pp. 2327-2340, 2004

Abstract Objective: The Proscar Long-Term Efficacy and Safety Study (PLESS) and the Medical Therapy of Prostatic Symptoms (MTOPS) study provide new evidence regarding the benefits of finasteride in the treatment of benign prostatic hyperplasia (BPH). The objective of this study was to utilize data from the PLESS and MTOPS studies to assess the cost-utility of finasteride and finasteride in combination with doxazosin, compared to doxazosin alone in men with moderate to severe BPH symptoms.
Methods: A semi-Markov decision analytic model was constructed to estimate the clinical consequences, costs and cost-utility of doxazosin, finasteride, and combination therapy. Analyses were… More >

Mostafa M. Elhilali, J. Curtis Nickel

Canadian Journal of Urology, Vol.10, No.2, pp. 1799-1802, 2003

Abstract The management of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia over the last decade underwent many changes. The introduction of many medical options including alpha blockers and 5 alpha reductase inhibitors provided alternatives to what used to be surgery or “watchful waiting”.
Alpha blockers evolved over the years from non specific alpha blockers to alpha 1 selective and then to alpha 1a selective with a wider acceptance due to lack of need to titrate and a better safety profile.
5 alpha reductase inhibitor (finasteride) passed through a lot of changes from being the… More >

Jiansong Wang¹, Mary A. Bissada², H. Oliver Williamson³, Hossam Yakout², Nabil K. Bissada²

Canadian Journal of Urology, Vol.9, No.3, pp. 1563-1564, 2002

Abstract We describe a case of salt-losing congenital adrenal hyperplasia due to 21-hydroxylase deficiency complicated by a right adrenal adenoma. The development of adrenal adenoma or carcinoma in-patients with congenital adrenal hyperplasia (CAH) is rare; the etiology is not clear but is thought to be related to inadequate glucocorticoid therapy. Tumor formation is postulated to be a consequence of ACTH hypersecretion, which results from the lack of glucocorticoid synthesis. Our patient underwent clitorectomy and multiple constructive procedures as a newborn baby; she was managed with hormone replacement for many years. However while she took adequate mineralocortocoid More >

K. Nesnas¹, A. Abdul-Latif²

CMES-Computer Modeling in Engineering & Sciences, Vol.2, No.3, pp. 373-388, 2001, DOI:10.3970/cmes.2001.002.373

Abstract Large plastic collapse of an identical pair of cylinders of various geometries having the same length and volume is studied under lateral compressive load. Superplastic material is employed as a representative material to simulate the classical engineering material behavior under high strain rate. The effects of the strain rate and the geometry of cylinders on the plastic collapse are taken into account. The experimental study is conducted using a structure in which one cylinder is superplastic and the other is steel (referred to as deformable and non-deformable situation "DND''). The actual structure (DND) and that More >