Kevin R. Loughlin

Canadian Journal of Urology, Vol.28, No.2, pp. 10584-10588, 2021

Abstract Introduction: Five-alpha reductase (5-AR) deficiency was first identified by Imperato-McGinley and Walsh as the cause of pseudohermaphroditism in two separate studies. The discoveries led to the development of finasteride (inhibitor of type 2 isoenzyme of 5-AR) and dutasteride (inhibitor of type 1 and type 2 isoenzymes of 5-AR).
Both drugs have been proven effective for the treatment of benign prostatic hyperplasia, improving voiding symptoms, reducing the risk of urinary retention, and decreasing the need for prostate surgery.
Five-alpha reductase inhibitors (5-ARIs) have also been demonstrated to be chemopreventive agents, reducing the risk of prostate cancer, although the… More >

Dean Elterman¹, Shaun Shepherd¹, Seyed Hossein Saadat¹, Mark N. Alshak², Naeem Bhojani³, Kevin C. Zorn⁴, Enrique Rijo⁵, Vincent Misrai⁶, Katherine Lajkosz¹, Bilal Chughtai²

Canadian Journal of Urology, Vol.28, No.5, pp. 10824-10833, 2021

Abstract Introduction: Half of men aged > 60 years will develop benign prostatic hyperplasia (BPH) with 40% of these men having moderate-to-severe lower urinary tract symptoms (LUTS). There is limited knowledge on a head-to-head comparison of prostatic urethral lift (UroLift) and convective water vapor ablation (Rezum) for the treatment of LUTS secondary to BPH. We sought to compare randomized controlled trials with 3-year clinical outcome data.
Materials and methods: After a thorough literature search, two multicenter sham-controlled double-blind randomized trials for UroLift and Rezum were identified and compared. Both studies had similar designs, baseline characteristics, reported outcomes, and… More >

Samuel Helrich¹, Wesley Pate¹, Nishant Garg¹, Philip Barbosa², Shaun Wason¹

Canadian Journal of Urology, Vol.28, No.6, pp. 10889-10899, 2021

Abstract Introduction: To compare pelvic ultrasound (PUS) and transrectal ultrasound (TRUS) to magnetic resonance imaging (MRI) in the estimation of prostate size.
Materials and methods: After IRB approval, we performed a single-center, retrospective study of 91 patients who had prostate sizing between August 2013 and June 2017. Correlation, reliability, and agreement between PUS, TRUS, and MRI were calculated through the Pearson coefficient, intraclass correlation coefficient, and Bland-Altman analysis, respectively. Data was stratified by prostate size, body mass index, and time between imaging acquisition.
Results: A total of 91 patients underwent all three imaging methods. Median age was 64, median… More >

Kaixin Qi, Guiying Wang^*, Yinggang Huang, Pengfei Fang

Journal of New Media, Vol.3, No.3, pp. 109-118, 2021, DOI:10.32604/jnm.2021.019694 - 13 July 2021

Abstract A visual pH indicator through purple cabbage dye is selected to test the freshness of venison. Chitosan and cassava starch of an equal weight were used to prepare the film-forming matrix of the indicator. The crystallization of natural purple cabbage dyes with a weight ratio of 5%, 10%, 20% and 40% were added to the matrix, respectively. The pH color test showed that the natural purple cabbage lyophilized powder with a weight ratio of 40% was the best for the pH indicator, which was used to test the freshness of venison stored at 4℃. More >

Sankar Sennan¹, Somula Ramasubbareddy², Anand Nayyar^3,4, Yunyoung Nam^5,*, Mohamed Abouhawwash^6,7

CMC-Computers, Materials & Continua, Vol.69, No.1, pp. 351-371, 2021, DOI:10.32604/cmc.2021.017360 - 04 June 2021

Abstract Energy conservation is a significant task in the Internet of Things (IoT) because IoT involves highly resource-constrained devices. Clustering is an effective technique for saving energy by reducing duplicate data. In a clustering protocol, the selection of a cluster head (CH) plays a key role in prolonging the lifetime of a network. However, most cluster-based protocols, including routing protocols for low-power and lossy networks (RPLs), have used fuzzy logic and probabilistic approaches to select the CH node. Consequently, early battery depletion is produced near the sink. To overcome this issue, a lion optimization algorithm (LOA)… More >

FANGLIAN HE¹, WEIQING DONG^1,*, SHAOLONG WEI^2,*, ZUYANG QIU³, JINGLI HUANG⁴, HUIPING JIANG¹, SHIYU HUANG¹, LILI LIU³

BIOCELL, Vol.45, No.3, pp. 785-796, 2021, DOI:10.32604/biocell.2021.014418 - 03 March 2021

Abstract Taro (Colocasia esculenta (L.) Schott) is an important crop in Africa, Southeast Asia, and subtropics and is used as a food and medicine. The purple color pigmentation is an appealing character in taro. We sampled taro corms of the cultivar ‘Lipu Taro’ at four developmental stages, including LPYS1 (without purple pigment, 50 days of development (DOD)), LPYS2 (very few purple pigments, 75 DOD), LPYS3 (moderate purple pigments, 115 DOD) and LPYS4 (high purple pigments, 205 DOD). The purpose of our study was to identify the key genes underpinning the purple pigmentation in taro based on RNA-sequencing.… More >

Yuhang Long¹, Jingyi Wang^2,*

FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.1, pp. 181-187, 2021, DOI:10.32604/fdmp.2021.011185 - 09 February 2021

Abstract This study considers P.O42.5 cement from different sources and evaluates the related surplus coefficient (defined as the proportionality factor linking the measured compressive strength value of the cement after 28 days to the “standard” value of cement strength). The needed tests have been conducted using a mixer, a pressure testing machine, a flexural testing machine, a vibrating table a ramming rod, a feeder and a metal ruler. The average value of the measured cement strength surplus coefficient of cement produced by five distinct cement manufacturers has been found to be 1.16. These results can be More >

Arslan Musaddiq¹, Rashid Ali², Jin-Ghoo Choi¹, Byung-Seo Kim^3,*, Sung-Won Kim¹

CMC-Computers, Materials & Continua, Vol.67, No.1, pp. 799-814, 2021, DOI:10.32604/cmc.2021.014751 - 12 January 2021

Abstract The Internet of Things (IoT) has numerous applications in every domain, e.g., smart cities to provide intelligent services to sustainable cities. The next-generation of IoT networks is expected to be densely deployed in a resource-constrained and lossy environment. The densely deployed nodes producing radically heterogeneous traffic pattern causes congestion and collision in the network. At the medium access control (MAC) layer, mitigating channel collision is still one of the main challenges of future IoT networks. Similarly, the standardized network layer uses a ranking mechanism based on hop-counts and expected transmission counts (ETX), which often does… More >

Mihir Desai¹, Mo Bidair², Naeem Bhojani³, Andrew Trainer⁴, Andrew Arther⁴, Eugene Kramolowsky⁵, Leo Doumanian¹, Dean Elterman⁶, Ronald P. Kaufman, Jr.⁷, James Lingeman⁸, Amy Krambeck⁸, Gregg Eure⁹, Gopal Badlani¹⁰, Mark Plante¹¹, Edward Uchio¹², Greg Gin¹², Larry Goldenberg¹³, Ryan Paterson¹³, Alan So¹³, Mitchell R. Humphreys¹⁴, Claus G. Roehrborn¹⁵, Steven Kaplan¹⁶, Jay Motola¹⁶, Kevin C. Zorn³

Canadian Journal of Urology, Vol.27, No.2, pp. 10147-10153, 2020

Abstract Introduction: To report 2-year safety and effectiveness of the Aquablation procedure for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) and large-volume 80-150 cc prostates.
Materials and methods: Between September-December 2017, 101 men with moderate-to-severe BPH symptoms and prostate volumes of 80-150 cc underwent an ultrasound-guided robotically executed Aquablation procedure in a prospective multicenter international clinical trial (WATER II). Baseline, procedural and follow-up parameters were recorded at baseline and scheduled postoperative visits. Herein we report 2-year safety and efficacy for this cohort.
Results: Mean prostate volume was 107 cc (range 80-150 cc). Mean IPSS improved from… More >

Christopher H. Cantrill¹, Kevin C. Zorn², Dean S. Elterman³, Ricardo R. Gonzalez⁴

Canadian Journal of Urology, Vol.26, No.3, pp. 9787-9793, 2019

Abstract Benign prostatic hyperplasia (BPH) and accompanying lower urinary tract symptoms (LUTS) sits in the top ten prominent and costly disease conditions in men over 50 years of age. In the United States it is the most common diagnosis made by urologists for men 45 to 74 years of age. Twenty percent of the population will reach 65 years of age or older by 2030, and those over 85 years will represent the fastest growing segment of our population. The prevalence of symptomatic BPH increases proportionally with the aging population. It is estimated that BPH now More >