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  • Open Access


    Predicting Genotype Information Related to COVID-19 for Molecular Mechanism Based on Computational Methods

    Lejun Gong1,2,*, Xingxing Zhang1, Li Zhang3, Zhihong Gao4

    CMES-Computer Modeling in Engineering & Sciences, Vol.129, No.1, pp. 31-45, 2021, DOI:10.32604/cmes.2021.016622

    Abstract Novel coronavirus disease 2019 (COVID-19) is an ongoing health emergency. Several studies are related to COVID-19. However, its molecular mechanism remains unclear. The rapid publication of COVID-19 provides a new way to elucidate its mechanism through computational methods. This paper proposes a prediction method for mining genotype information related to COVID-19 from the perspective of molecular mechanisms based on machine learning. The method obtains seed genes based on prior knowledge. Candidate genes are mined from biomedical literature. The candidate genes are scored by machine learning based on the similarities measured between the seed and candidate More >

  • Open Access


    A Vicenary Analysis of SARS-CoV-2 Genomes

    Sk Sarif Hassan1, Ranjeet Kumar Rout2, Kshira Sagar Sahoo3, Nz Jhanjhi4, Saiyed Umer5, Thamer A. Tabbakh6,*, Zahrah A. Almusaylim7

    CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 3477-3493, 2021, DOI:10.32604/cmc.2021.017206

    Abstract Coronaviruses are responsible for various diseases ranging from the common cold to severe infections like the Middle East syndromes and the severe acute respiratory syndrome. However, a new coronavirus strain known as COVID-19 developed into a pandemic resulting in an ongoing global public health crisis. Therefore, there is a need to understand the genomic transformations that occur within this family of viruses in order to limit disease spread and develop new therapeutic targets. The nucleotide sequences of SARS-CoV-2 are consist of several bases. These bases can be classified into purines and pyrimidines according to their… More >

  • Open Access


    A Binomial Model Approach: Comparing the R0 Values of SARS-CoV-2 rRT-PCR Data from Laboratories across Northern Cyprus

    Nazife Sultanoglu1,2,*, Nezihal Gokbulut3, Tamer Sanlidag2, Evren Hincal2,3, Bilgen Kaymakamzade2,3, Murat Sayan2,4

    CMES-Computer Modeling in Engineering & Sciences, Vol.128, No.2, pp. 717-729, 2021, DOI:10.32604/cmes.2021.016297

    Abstract Northern Cyprus has implemented relatively strict measures in the battle against the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The measures were introduced at the beginning of the COVID-19 pandemic, in order to prevent the spread of the disease. One of these measures was the use of two separate real-time reverse transcription polymerase chain reaction (rRT-PCR) tests for SARS-CoV-2 referred to as the double screening procedure, which was adopted following the re-opening of the sea, air and land borders for passengers after the first lockdown. The rRT-PCR double screening procedure involved reporting a… More >

  • Open Access


    Data-Fusion for Epidemiological Analysis of Covid-19 Variants in UAE

    Anoud Bani-Hani1,*, Anaïs Lavorel2, Newel Bessadet3

    CMC-Computers, Materials & Continua, Vol.68, No.3, pp. 3895-3913, 2021, DOI:10.32604/cmc.2021.015355

    Abstract Since December 2019, a new pandemic has appeared causing a considerable negative global impact. The SARS-CoV-2 first emerged from China and transformed to a global pandemic within a short time. The virus was further observed to be spreading rapidly and mutating at a fast pace, with over 5,775 distinct variations of the virus observed globally (at the time of submitting this paper). Extensive research has been ongoing worldwide in order to get a better understanding of its behaviour, influence and more importantly, ways for reducing its impact. Data analytics has been playing a pivotal role… More >

  • Open Access


    Computational Technique for Effectiveness of Treatments Used in Curing SARS-CoV-2

    Wael Alosaimi1, Rajeev Kumar2,*, Abdullah Alharbi1, Hashem Alyami3, Alka Agrawal4, Gaurav Kaithwas5, Sanjay Singh6, Raees Ahmad Khan4

    Intelligent Automation & Soft Computing, Vol.28, No.3, pp. 617-628, 2021, DOI:10.32604/iasc.2021.016703

    Abstract COVID-19 pandemic has unleashed an unprecedented humanitarian crisis in the world at present. With each passing day, the number of patients afflicted with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is rising at an alarming pace, so much so that some countries are now combating the second wave of the contagion. As the death ratio due to the Virus increases, the medical fraternity and pharmacologists are working relentlessly to identify and prescribe a standardized and effective course of treatment for treating COVID-19 patients. However, medical specialists are confused about opting for the most efficacious course… More >

  • Open Access


    Mesenchymal stem cell-derived exosome as a nano weapon to target the COVID-19 pandemic


    BIOCELL, Vol.45, No.3, pp. 517-520, 2021, DOI:10.32604/biocell.2021.014621

    Abstract In these times of despair when a nano-sized organism, the SARS-CoV-2, has rendered the human race helpless, made the global health status decline, and drowned the world economy, a ray of hope comes from another nano-sized particle, the exosome. The potential of mesenchymal stem cells has already been established in COVID-19; however, cell-based therapy has its risks. We thereby propose cell-free therapy using stem cells-derived exosomes to fight against COVID-19, as they can be a game-changer owing to their immunomodulatory nature, which combats the cytokine storm characterizing this disease, and their practical efficiency, which will More >

  • Open Access


    Analyzing COVID-2019 Impact on Mental Health Through Social Media Forum

    Huma1, Muhammad Khalid Sohail2, Nadeem Akhtar3, Dost Muhammad3, Humaira Afzal4, Muhammad Rafiq Mufti5, Shahid Hussain6,*, Mansoor Ahmed1

    CMC-Computers, Materials & Continua, Vol.67, No.3, pp. 3737-3748, 2021, DOI:10.32604/cmc.2021.014398

    Abstract This study aims to identify the potential association of mental health and social media forum during the outbreak of COVID-19 pandemic. COVID-19 brings a lot of challenges to government globally. Among the different strategies the most extensively adopted ones were lockdown, social distancing, and isolation among others. Most people with no mental illness history have been found with high risk of distress and psychological discomfort due to anxiety of being infected with the virus. Panic among people due to COVID-19 spread faster than the disease itself. The misinformation and excessive usage of social media in… More >

  • Open Access


    Prediction of COVID-19 Cases Using Machine Learning for Effective Public Health Management

    Fahad Ahmad1,*, Saleh N. Almuayqil2, Mamoona Humayun2, Shahid Naseem3, Wasim Ahmad Khan4, Kashaf Junaid5

    CMC-Computers, Materials & Continua, Vol.66, No.3, pp. 2265-2282, 2021, DOI:10.32604/cmc.2021.013067

    Abstract COVID-19 is a pandemic that has affected nearly every country in the world. At present, sustainable development in the area of public health is considered vital to securing a promising and prosperous future for humans. However, widespread diseases, such as COVID-19, create numerous challenges to this goal, and some of those challenges are not yet defined. In this study, a Shallow Single-Layer Perceptron Neural Network (SSLPNN) and Gaussian Process Regression (GPR) model were used for the classification and prediction of confirmed COVID-19 cases in five geographically distributed regions of Asia with diverse settings and environmental… More >

  • Open Access


    Antimicrobial Materials: New Strategies to Tackle Various Pandemics

    Samarjeet Singh Siwal1,2, Qibo Zhang1,3,*, Adesh Kumar Saini4, Vijay Kumar Thakur5,6,*

    Journal of Renewable Materials, Vol.8, No.12, pp. 1543-1563, 2020, DOI:10.32604/jrm.2020.014597

    Abstract Coronaviruses are responsible for a developing budgetary, human and fatality trouble, as the causative factor of infections, for example, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has been well recognized that SARS-CoV-2 may survive under severe atmosphere circumstances. Hence, efficient containment approaches, for example, sanitizing, are crucial. Commonly, living compounds contribute a substance of chemical heterogeneity, with antiviral movement, and therefore can have efficacy as therapeutic tools toward coronavirus diseases. Here, in this review article, we have described the antimicrobialbased materials, which can be used to inhibit the spreading of the COVID-19. We have More >

  • Open Access


    Potential Inhibitory Effect of Vitamins Against COVID-19

    Kashaf Junaid1,*, Sumera Qasim2, Humaira Yasmeen3, Hasan Ejaz1, Abdullah Alsrhani1, Muhammad Ikram Ullah1, Fahad Ahmad4, Abdul Rehman5

    CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 707-714, 2021, DOI:10.32604/cmc.2020.012976

    Abstract Coronavirus disease 2019 (COVID-19) is a current pandemic that has affected more than 195 countries worldwide. In this severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, when treatment strategies are not yet clear and vaccines are not available, vitamins are an excellent choice to protect against this viral infection. The rationale behind this study was to examine the inhibitory effect of vitamins B, C, and D against the main protease of SARSCoV-2 and angiotensin-converting enzyme 2 (ACE2), which have critical rolesin the immune system. Molecular docking, performed by using MOE-Dock of the Chemical Computing Group,… More >

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