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  • Open Access

    ARTICLE

    The Effects of Cyclic Strains on the Hybrid Aligned Nanofibrous Scaffold Seeded with Smooth Muscle Cells

    J. W. Shin1,3, Y. J. Kim2, J. H. Kim1, Y. J. Lee3, S. J. Heo3, Y. M. Hwang1,3, D. H. Kim1,3, J. W. Shin1,3*

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 223-224, 2006, DOI:10.32604/mcb.2006.003.223

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    A Frictionless Contact Algorithm for Meshless Methods

    R. Vignjevic1, T. De Vuyst2, J. C. Campbell1

    CMES-Computer Modeling in Engineering & Sciences, Vol.13, No.1, pp. 35-48, 2006, DOI:10.3970/cmes.2006.013.035

    Abstract An approach to the treatment of contact problems involving frictionless sliding and separation under large deformations in meshless methods is proposed. The method is specially suited for non-structured spatial discretisation. The contact conditions are imposed using a contact potential for particles in contact. Inter-penetration is checked as a part of the neighbourhood search. In the case of conventional SPH contact conditions are enforced on the boundary layer 2h thick while in the case of the normalized SPH contact conditions are enforced for the particles lying on the contact surface. The implementation of the penalty based More >

  • Open Access

    ARTICLE

    Control of Stress Propagation in the Cytoplasm by Prestress and Loading Frequency

    Shaohua Hu*, Ning Wang

    Molecular & Cellular Biomechanics, Vol.3, No.2, pp. 49-60, 2006, DOI:10.3970/mcb.2006.003.049

    Abstract One fundamental question in cell biology is how mechanical stresses are distributed inside the cytoplasm. Recently we have developed a synchronous detection approach to map cytoplasmic displacements and stresses using yellow fluorescent protein tagged mitochondria as fiducial markers of the cytoskeleton (CSK) in response to a localized load applied via an RGD-coated magnetic bead (7). We have shown that stresses are propagated to remote sites in the cytoplasm, a finding that contradicts continuum model predictions. Here we show that long distance force propagation in the cytoplasm was abolished when the contractile prestress in the CSK More >

  • Open Access

    REVIEW

    Regulation of Vascular Smooth Muscle Cells and Mesenchymal Stem Cells by Mechanical Strain

    Kyle Kurpinski1,2,3, Jennifer Park1,2,3, Rahul G. Thakar1,2,3, Song Li1,2

    Molecular & Cellular Biomechanics, Vol.3, No.1, pp. 21-34, 2006, DOI:10.3970/mcb.2006.003.021

    Abstract Vascular smooth muscle cells (SMCs) populate in the media of the blood vessel, and play an important role in the control of vasoactivity and the remodeling of the vessel wall. Blood vessels are constantly subjected to hemodynamic stresses, and the pulsatile nature of the blood flow results in a cyclic mechanical strain in the vessel walls. Accumulating evidence in the past two decades indicates that mechanical strain regulates vascular SMC phenotype, function and matrix remodeling. Bone marrow mesenchymal stem cell (MSC) is a potential cell source for vascular regeneration therapy, and may be used to More >

  • Open Access

    ARTICLE

    Efficient Green's Function Modeling of Line and Surface Defects in Multilayered Anisotropic Elastic and Piezoelectric Materials1

    B. Yang2, V. K. Tewary3

    CMES-Computer Modeling in Engineering & Sciences, Vol.15, No.3, pp. 165-178, 2006, DOI:10.3970/cmes.2006.015.165

    Abstract Green's function (GF) modeling of defects may take effect only if the GF as well as its various integrals over a line, a surface and/or a volume can be efficiently evaluated. The GF is needed in modeling a point defect, while integrals are needed in modeling line, surface and volumetric defects. In a matrix of multilayered, generally anisotropic and linearly elastic and piezoelectric materials, the GF has been derived by applying 2D Fourier transforms and the Stroh formalism. Its use involves another two dimensions of integration in the Fourier inverse transform. A semi-analytical scheme has… More >

  • Open Access

    ARTICLE

    SPH in a Total Lagrangian Formalism

    Rade Vignjevic1, Juan R. Reveles1, James Campbell1

    CMES-Computer Modeling in Engineering & Sciences, Vol.14, No.3, pp. 181-198, 2006, DOI:10.3970/cmes.2006.014.181

    Abstract To correct some of the main shortcomings of conventional SPH, a version of this method based on the Total Lagrangian formalism, T. Rabczuk, T. Belytschko and S. Xiao (2004), is developed. The resulting scheme removes the spatial discretisation instability inherent in conventional SPH, J. Monaghan (1992).
    The Total Lagrangian framework is combined with the mixed correction which ensures linear completeness and compliance with the patch test, R. Vignjevic, J. Campbell, L. Libersky (2000). The mixed correction utilizes Shepard Functions in combination with a correction to derivative approximations.
    Incompleteness of the kernel support combined with… More >

  • Open Access

    ARTICLE

    Parallel iterative procedures for a computational electromagnetic modeling based on a nonconforming mixed finite element method

    Taeyoung Ha1, Sangwon Seo2, Dongwoo Sheen3

    CMES-Computer Modeling in Engineering & Sciences, Vol.14, No.1, pp. 57-76, 2006, DOI:10.3970/cmes.2006.014.057

    Abstract We present nonoverlapping domain decomposition methods for the approximation of both electromagnetic fields in a three-dimensional bounded domain satisfying absorbing boundary conditions. A Seidel-type domain decomposition iterative method is introduced based on a hybridization of a nonconforming mixed finite element method. Convergence results for the numerical procedure are proved by introducing a suitable pseudo-energy. The spectral radius of the iterative procedure is estimated and a method for choosing an optimal matching parameter is given. A red-black Seidel-type method which is readily parallelizable is also introduced and analyzed. Numerical experiments confirm that the presented algorithms are faster than More >

  • Open Access

    ARTICLE

    Optimal Tetrahedralization for Small Polyhedron: A New Local Transformation Strategy for 3-D Mesh Generation and Mesh Improvement

    Liu Jianfei1,2, Sun Shuli1,3, Wang Dachuan1

    CMES-Computer Modeling in Engineering & Sciences, Vol.14, No.1, pp. 31-44, 2006, DOI:10.3970/cmes.2006.014.031

    Abstract Local transformation, or topological re-connection, is one of effective procedures of mesh improvement method, especially in three-dimensional situation. The commonly used local transformations for tetrahedral mesh involve changing in mesh topology (i.e. node-element connectivity relationship) within a relatively small region composed of several tetrahedra, such as 2-3 flip, 3-2 flip, 2-2 flip, 4-4 flip, etc. Although these local transformations are easy to implement and effective in removing poorly-shaped tetrahedra, it is still possible to improve the quality of mesh further by expanding the space of transformation region. In this paper, the concept of optimal tetrahedralization forMore >

  • Open Access

    ARTICLE

    Prediction of Crack Growth in Steam Generator Tubes Using Monte Carlo Simulation

    Jae Bong Lee1, Jai Hak Park1, Sung Ho Lee2, Hong-Deok Kim2, Han-Sub Chung2

    CMES-Computer Modeling in Engineering & Sciences, Vol.11, No.1, pp. 9-16, 2006, DOI:10.3970/cmes.2006.011.009

    Abstract The growth of stress corrosion cracks in steam generator tubes is predicted using the Monte Carlo simulation and statistical approaches. The statistical parameters that represent the characteristics of crack growth and crack initiation are derived from in-service inspection (ISI) non-destructive evaluation (NDE) data. Based on the statistical approaches, crack growth models are proposed and applied to predict crack distribution at the end of cycle (EOC). Because in-service inspection (ISI) crack data is different from physical crack data, a simple method for predicting the physical number of cracks from periodic in-service inspection data is proposed in More >

  • Open Access

    ARTICLE

    Nonlinear Dynamic Response Analysis of Steel Frames under Seismic Action

    T. Yoda1, N. Kodama2

    CMES-Computer Modeling in Engineering & Sciences, Vol.11, No.1, pp. 1-8, 2006, DOI:10.3970/cmes.2006.011.001

    Abstract A nonlinear dynamic response analysis of a box section steel rigid frame under seismic action is proposed on the basis of a beam model. The average stress-strain relation of the beam model can be formulated for transverse stiffener spacing, in which stress-strain relation after local buckling is assumed. As a result of the present study, the maximum lateral displacements and the residual displacements of a box section steel rigid frame were well estimated by the proposed beam element model that considers the deterioration effect due to local buckling. More >

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