Edouard J. Trabulsi¹, Robert A. Linden¹, Leonard G. Gomella¹, Davis E. McGinnis², Stephen E. Strup³, Costas D. Lallas¹

Canadian Journal of Urology, Vol.15, No.2, pp. 3994-3999, 2008

Abstract Purpose: The addition of robotic assistance with the da Vinci surgical system for performing laparoscopic radical prostatectomy has been reported to improve surgical outcomes. In order to evaluate the benefit of robotic assistance to improve cancer control in a center with an established laparoscopic radical prostatectomy program, we evaluated the incidence of positive surgical margins in both transperitoneal laparoscopic (LRP) and robotically assisted laparoscopic radical prostatectomy (RALP).
Materials and methods: We performed an Institutional Review Board (IRB) approved, retrospective review of 247 men with clinically localized prostate cancer treated with either a LRP or a RALP from… More >

David B. Samadi¹, Bilal Chughtai², Ardavan Akhavan³, Khurshid Guru⁴, Jamil Rehman⁵

Canadian Journal of Urology, Vol.15, No.3, pp. 4109-4111, 2008

Abstract Primary soft tissue sarcomas of the genitourinary tract are rarely seen, especially in the seminal vesicle. While sarcomas have been reported in the seminal vesicle, this is the fi rst report of a smooth muscle neoplasm, of uncertain malignant potential, involving the seminal vesicle. The fi nding was incidental, following robotic-assisted radical retropubic prostatectomy for prostate cancer. To our knowledge, this is also the fi rst report of a primary seminal vesicle tumor found following radical prostatectomy. A clinical case review and a brief review of the literature are presented. More >

Amy E. Krambeck¹, Michael A. Farrell², Matthew R. Callstrom², Thomas D. Atwell², J. William Charboneau², George K. Chow¹, David S. DiMarco¹, David E. Patterson¹

Canadian Journal of Urology, Vol.15, No.4, pp. 4163-4168, 2008

Abstract Objectives: Radiofrequency ablation (RFA) is a minimally invasive therapy aimed at maximal preservation of renal function in the nonsurgical renal mass patient. We evaluate our experience with RFA of renal tumors in the solitary kidney.
Patients and methods: A retrospective review of all patients with a solitary kidney treated with RFA for renal mass was performed. Two radiologists reviewed all images. From December 2001 to June 2006, 55 renal tumors were treated with RFA in 30 patients with a solitary kidney. Percutaneous approach was used in 44 tumors (26 patients) and intraoperative open approach in 11 tumors… More >

Eric Winquist, Mary J. Mackenzie, George Rodrigues

Canadian Journal of Urology, Vol.15, No.4, pp. 4147-4152, 2008

Abstract Introduction: Given the improved therapeutic efficacy and acceptable side effect profile with current cryotechnology, we wish to better understand the attitudes of community urologists expressing interest in this treatment modality toward the adoption of cryotherapy in their practice.
Methods: A retrospective survey was conducted with information gathered on 50 responding physicians who attended a cryosurgery workshop between February 2004 and September 2006. Specifics such as demographics and professional background, reasons for interest in cryosurgery, and the current status of cryosurgery in the physicians' practice were collected and analyzed using SPSS, version 14 (Chicago, IL).
Results: Of the responding… More >

Christopher J. DiBlasio¹, Jessica Hammett¹, John B. Malcolm¹, Beth A. Judge², Jamie H. Womack², Matthew C. Kincade¹, Mitchell L. Ogles¹, John M. Mancini¹, Anthony L. Patterson¹, Robert W. Wake¹, Ithaar H. Derweesh¹

Canadian Journal of Urology, Vol.15, No.5, pp. 4249-4256, 2008

Abstract Objective: Androgen deprivation therapy (ADT) remains a widely utilized modality for treatment of localized and advanced prostate cancer. While ADT-induced alterations in testosterone have demonstrated impacts on quality of life, the effects on mental health remain ill-defined. We investigated the prevalence of de novo psychiatric illness and predictive factors following ADT induction for prostate cancer.
Materials and methods: We retrospectively reviewed patients receiving ADT for prostate cancer at our institution between 1/1989-7/2005, excluding men receiving only neoadjuvant ADT. Variables included age, race, body mass index, prostate-specific antigen (PSA), Gleason sum, clinical stage, ADT type (medical/surgical) and schedule… More >

Andrew J. Macnab, Lynn Stothers

Canadian Journal of Urology, Vol.15, No.5, pp. 4241-4248, 2008

Abstract Introduction: Near infrared spectroscopy (NIRS) is a non-invasive optical technique able to monitor changes in the concentration of oxygenated and deoxygenated hemoglobin in the bladder detrusor during bladder filling and emptying.
Objective: To evaluate the ability of a new NIRS instrument and algorithm to classify male patients with LUTS as obstructed or unobstructed based on comparison with classification via conventional invasive urodynamics (UDS).
Method: Male patients with LUTS were recruited and underwent uroflow and urodynamic pressure flow studies with simultaneous transcutaneous NIRS monitoring following measurement of post residual volume (PVR) via ultrasound. Data analysis first classified each subject… More >

K. Clint Cary, Chandru P. Sundaram

Canadian Journal of Urology, Vol.15, No.6, pp. 4431-4432, 2008

Abstract Primitive neuroectodermal tumor of renal origin, PNET, is extraordinarily rare and often lethal. Here we present a case of renal PNET managed successfully by radical nephrectomy, caval thrombectomy, and retroperitoneal lymph node dissection. More >

Gabriel P. Haas

Canadian Journal of Urology, Vol.15, No.6, pp. 4345-4345, 2008

Abstract This article has no abstract. More >

JIANLI SHI, WENYAN MEI, JING YANG

BIOCELL, Vol.32, No.3, pp. 259-263, 2008, DOI:10.32604/biocell.2008.32.259

Abstract As the key component of many hemoproteins (heme-containing proteins), heme is involved in a broad range of biological processes. Enzymes required for heme biosynthesis and degradation pathways are evolutionarily conserved. While heme metabolism has been studied extensively, the expression of heme metabolism enzymes during development has not been described. Here, we report that all heme biosynthases and two heme oxygenases, which initiate heme degradation, are dynamically expressed during Xenopus embryonic development. All heme synthases, with the exception of aminolevulinic acid synthase 2, are maternally expressed. At neurula stage, heme synthases are expressed in the developing neural… More >

ELEONIDAS MOURA LIMA^1,2, MARIANA FERREIRA LEAL³, MARÍLIA DE ARRUDA CARDOSO SMITH³, ROMMEL RODRÍGUEZ BURBANO⁴, PAULO PIMENTEL DE ASSUMPÇÃO⁵, MARIA JOSE BELLO⁶, JUAN ANTONIO REY⁶, FRANCINALDO FERREIRA DE LIMA⁷, CACILDA CASARTELLI²

BIOCELL, Vol.32, No.3, pp. 237-243, 2008, DOI:10.32604/biocell.2008.32.237

Abstract Gastric cancer is one of the most common malignancies. DNA methylation is implicated in DNA mismatch repair genes deficiency. In the present study, we evaluated the methylation status of MLH1, MSH2, MSH6 and PMS2 in 20 diffuse- and 26 intestinal-type gastric cancer samples and 20 normal gastric mucosal of gastric cancer patients from Northern Brazil. We found that none of the nonneoplastic samples showed methylation of any gene promoter and 50% of gastric cancer samples showed at least one methylated gene promoter. Methylation frequencies of MLH1, MSH2, MSH6 and PMS2 promoter were 21.74%, 17.39%, 0% and 28.26% respectively… More >