Ethan D. Grober, John Tsihlias, Michael A. S. Jewett, Joan M. Sweet, Andrew J. Evans, John Trachtenberg, Mike Robinette, Robert K. Nam

Canadian Journal of Urology, Vol.11, No.1, pp. 2157-2162, 2004

Abstract Objectives: To correlate the primary Gleason pattern among patients with biopsy-derived Gleason 7 tumors with the radical prostatectomy specimen Gleason grading and other clinical and pathologic outcomes.
Methods and materials: Among 474 patients who underwent radical prostatectomy for clinically localized prostate cancer between 1997-2001, 205 (43%) had Gleason 7/10 tumors on pre-operative needle biopsy. Among these patients, 148 (72.2%) were assigned a primary Gleason 3 pattern (3+4=7) and 57 (27.8%) were assigned a primary Gleason 4 pattern (4+3=7). The two groups were compared with respect to age, serum PSA levels, Gleason grade in the radical prostatectomy specimen,… More >

Joshua D. Wiesenthal, Helen Ettler¹, Hassan Razvi²

Canadian Journal of Urology, Vol.11, No.1, pp. 2133-2135, 2004

Abstract Epidermoid cysts of the testicle are rare, benign lesions that are clinically indistinguishable from malignant germ cell tumors. A scrotal mass in a 27-year-old man was incidentally detected by his family physician, and confirmed to be intratesticular by ultrasound. Radical orchidectomy was performed revealing the pathologic diagnosis. The presentation, evaluation and management of epidermoid cysts are discussed. More >

Mark A. Lomaga¹, Charles Hayter²

Canadian Journal of Urology, Vol.11, No.2, pp. 2205-2206, 2004

Abstract We report a case of a 73 year-old male diagnosed with T1 N0 M0 prostate cancer, Gleason score 7, undergoing a course of radical radiotherapy using 7600 cGY delivered in 38 fractions. Several hours after receiving his 27th fraction, he reported experiencing a painful penile erection lasting more than 6 hours. A history and several investigations were conducted to determine the etiology of this adverse event. Although several possible etiologies were considered, the two most likely possibilities were direct prostate-irradiation and/or his use of alfuzosin, a novel alpha 1-adrenergic antagonist. A literature search revealed one More >

S. Tyldesley¹, A. Coldman², T. Pickles¹

Canadian Journal of Urology, Vol.11, No.4, pp. 2316-2321, 2004

Abstract Objective: To determine whether men who relapse after neoadjuvant androgen ablation (NAA) and high-dose radiation therapy (RT) have faster PSA doubling times (PSAdt) than those who are treated with RT alone.
Materials and methods: From a prospective database of 1880 patients treated with RT for localized prostate cancer, patients were selected for further study if they had a rising PSA profile >1 ng/ml, and were treated with either no NAA, or prolonged NAA (defined as 3-12 months NAA) with a minimum 5 years follow-up. The PSAdt was calculated from the exponential line of best fit from the… More >

Richard D. Sowery, D. Robert Siemens

Canadian Journal of Urology, Vol.11, No.5, pp. 2407-2410, 2004

Abstract Objective: To characterize tumor growth of patients managed conservatively for renal cell carcinoma.
Methods: Patients electing conservative management of radiographically determined renal cell carcinomas were referred to a surveillance database. Exclusion criteria consisted of locally advanced disease (>T2) and those with metastatic disease. Clinical follow-up included renal imaging with ultrasound or computed tomography at least every 6 months.
Results: Twenty-two patients were originally managed conservatively, two of whom subsequently underwent nephrectomy because of rapid tumor growth. Mean follow-up was 26 months. Mean tumor volume and diameter at presentation was 62.4 cc and 4.08 cm respectively. Overall tumor growth More >

Jeffrey S. Montgomery¹, Brent K. Hollenbeck¹, Peter C. Fisher¹, Hedwig S. Murphy^2,4, Willie Underwood, III^1,3

Canadian Journal of Urology, Vol.11, No.5, pp. 2393-2395, 2004

Abstract Scrotal masses are common findings on genitourinary exam. The majority of these masses are benign and can be identified via history and physical exam alone. Question as to the origin of these masses merits additional evaluation that typically consists of an imaging study (e.g., ultrasound) and possibly serum tumor markers (e.g., HCG and AFP). In the end, surgical exploration may be necessary. Herein, the authors describe a rare case of benign paratesticular Schwannoma and discuss the clinical presentation and treatment of scrotal masses. More >

W. Kassouf, S. Binsaleh, D. D. Cohen, S. Carrier

Canadian Journal of Urology, Vol.11, No.6, pp. 2461-2462, 2004

Abstract We report a case of collecting duct carcinoma presenting as pyelonephritis with hypercalcemia and metastasis to the ovary. Case management and literature review being presented. More >

Oren M. Shemtov¹, Sidney B. Radomski², Juanita Crook³

Canadian Journal of Urology, Vol.11, No.6, pp. 2450-2455, 2004

Abstract Purpose: We undertook to determine if any significant differences in the efficacy of sildenafil citrate for erectile dysfunction (ED) exists between patients who have received external beam radiation or brachytherapy for prostate cancer.
Materials and methods: Thirty-one patients who had received external beam radiation and nineteen patients who had received brachytherapy for prostate cancer and were subsequently treated with sildenafil citrate for post-irradiation ED comprised the patient population. A chart analysis was performed to determine either the presence or absence of concomitant risk factors for ED (coronary artery disease, diabetes, hypertension and smoking history) as well as… More >

Eric Winquist¹, John J. Wilson², Mark Dorreen³, Ralph Wong⁴, Derek Jonker⁵, Neil Iscoe⁶

Canadian Journal of Urology, Vol.11, No.6, pp. 2445-2449, 2004

Abstract Objective: To assess the efficacy and tolerability of a 3-week outpatient schedule of intravenous gemcitabine and cisplatin in patients with locally advanced unresectable or metastatic transitional cell carcinoma of the urothelial tract (TCC).
Patients and methods: A two-stage phase II trial enrolled TCC patients with Karnofsky performance status >60, measurable disease, and adequate organ function. Prior adjunctive chemotherapy was allowed provided it had been completed at least 1 year prior to study entry. Treatment consisted of gemcitabine 1250 mg/m² iv days 1 and 8 plus cisplatin 70 mg/m² day 1 iv repeated every 21 days. The primary outcome… More >

MARÍA ESTHER DIUPOTEX-CHONG¹, NÉSTOR J. CAZZANIGA², ALEJANDRA HERNÁNDEZ-SANTOYO³, JOSÉ MIGUEL BETANCOURT-RULE⁴

BIOCELL, Vol.28, No.3, pp. 279-285, 2004, DOI:10.32604/biocell.2004.28.279

Abstract Mitotic chromosomes of the freshwater snail Pomacea patula catemacensis (Baker 1922) were analyzed on gill tissue of specimens from the type locality (Lake Catemaco, Mexico). The diploid number of chromosomes is 2n = 26, including nine metacentric and four submetacentric pairs; therefore, the fundamental number is FN = 52. No sex chromosomes could be identified. The same chromosome number and morphology were already reported for P. flagellata, i.e., the other species of the genus living in Mexico. The basic haploid number for family Ampullariidae was reported to be n° =°14 in the literature; so, its reduction to More >