Carlos Muñoz, Marcelo López, Manuel Olivares, Fernando Pizarro, Miguel Arredondo, Magdalena Araya

European Cytokine Network, Vol.16, No.4, pp. 261-265, 2005

Abstract Backgound. Copper (Cu) is an essential trace element for many biological processes including maintenance of both innate and acquired branches of immunity. Objective. To measure the effect of copper supplementation on IL-2 and TNF-α production in subjects with lower and higher ceuloplasmin (Cp) values within normal range. Design. Healthy adults (17 men and 16 women) with normal-low (low Cp) and normal-high Cp (high Cp) values were supplemented with 10 mg Cu/day (as CuSO₄) during 2 months. Method. Before and after supplementation blood mononuclear cells were incubated in the absence or presence of phytohaemagglutinin or lipopolysaccharide for… More >

Kaouther Snoussi¹, A. Donny Strosberg², Noureddine Bouaouina^1,3, Slim Ben Ahmed⁴, Lotfi Chouchane¹

European Cytokine Network, Vol.16, No.4, pp. 253-260, 2005

Abstract Objectives. Interleukin-1 (IL-1) and interleukin-6 (IL-6) are determining factors in the immune and inflammatory responses to tumors cells. Experimental data suggest that interleukin-1 and interleukin-6 play important roles in the development and progression of breast cancer. We designed a broad study to investigate the susceptibility and prognostic implications of the genetic variation in IL-1α, IL-1β and IL-6 in breast carcinoma. Experimental design. We used the polymerase chain reaction and restriction enzyme digestion to characterize the genetic variation of IL-1α, IL-1β and IL-6 in 305, unrelated Tunisian patients with breast carcinoma and 200 healthy control subjects.… More >

Pierre I. Karakiewicz, Paul Perrotte, Mike McCormack, François Peloquin, Jean-Paul Perreault, Philippe Arjane, Hughes Widmer, Fred Saad

Canadian Journal of Urology, Vol.12, Suppl.3, pp. 5-8, 2005

Abstract Introduction: Prostate biopsy strategies have greatly evolved over the past 2 decades.
Methods: We performed a literature review which addressed the initial and repeat biopsy schemes, pathologic risk factors for a positive repeat biopsy, and the ideal timing as well as the number of repeat biopsy sessions.
Results: Extended biopsy schemes (11-13 cores) should be used at initial and repeat biopsy. In the era of extended biopsy schemes, high-grade prostatic intraepithelial neoplasia no longer represents an independent predictor of prostate cancer on repeat biopsy. Conversely, the risk is appreciably increased with atypical small acinar proliferation, and its presence More >

Mana Al-Assiri, Zorn Kevin, Saleh Binsaleh, Peter T. K. Chan

Canadian Journal of Urology, Vol.12, No.1, pp. 2557-2559, 2005

Abstract Testicular cancer, which generally presents as a scrotal mass of variable sizes, is amongst the most common malignancies in men in the 15- to 35- year age group. A high inguinal orchiectomy is the standard approach for removal of a scrotal mass suspicious of being malignant. A recent report described a combined use of an inguinal incision, for early clamping of the spermatic cord, and a scrotal incision for orchiectomy of a large size testicular seminoma.1 We hereby report a case of a large size testis cancer removed using a single oblique inguinoscrotal incision. This More >

Chiu Yen M. Chang¹, Ken Reddy², Katherine Chorneyko³, Anil Kapoor¹

Canadian Journal of Urology, Vol.12, No.2, pp. 2603-2606, 2005

Abstract Primary small cell carcinoma of the ureter is a rare clinico-pathological entity. We present a report of primary ureteric small cell carcinoma and pathological correlates. More >

D. Scott Ernst¹, Penny Brasher², Peter M. Venner³, Piotr Czaykowski⁴, Malcolm J. Moore⁵, Leonard Reyno⁶, Eric Winquist¹, Roanne Segal⁷, Desiree Hao⁸

Canadian Journal of Urology, Vol.12, No.2, pp. 2575-2580, 2005

Abstract Objective: We evaluate the impact of surveillance programs on the outcome of men with clinical stage 1 NSGCT following orchidectomy.
Patients and methods: A retrospective review of 197 patients with a minimum of 2 years follow-up at seven cancer centres was conducted. Histological characteristics of the primary tumor were recorded for each patient. Surveillance protocols consisted of clinical assessments, chest X-rays, serum beta HCG (βHCG), alpha fetoprotein (αFP), and abdominopelvic CT. All clinic visits and test completions were tracked. In accordance with each centre's specific surveillance protocol, patient compliance was defined as missing no more than two assessments/year.
… More >

D. Robert Siemens¹, Karleen M. Schulze², William J. Mackillop², Michael D. Brundage², Patti A. Groome²

Canadian Journal of Urology, Vol.12, No.2, pp. 2568-2574, 2005

Abstract Introduction and objective: Despite the high incidence of prostate cancer in Canada, there is currently limited information describing how these patients are being managed. The aim of this study was to review the surgical waiting times for radical prostatectomy in Ontario, utilizing existing population-based cancer databases, and to describe factors associated with prolonged waiting times.
Methods: This is a retrospective, population-based, observational study of men diagnosed with prostate cancer in Ontario between 1980 and 2000. The sources of data include the Ontario Cancer Registry linked to hospital discharge data, as well as census data from Statistics Canada.… More >

Luis Antonio Guerra¹, John Pike¹, Guido Filler², Kristin Udjus³, Joseph de Nanassy⁴, Michael Leonard¹

Canadian Journal of Urology, Vol.12, No.5, pp. 2846-2848, 2005

Abstract Eosinophilic cystitis (EC) is an uncommon form of bladder inflammation. It is a rare disorder in children and fewer than 25 cases have been described in the literature. We report a case of eosinophilic cystitis mimicking a bladder tumor in a 3 year-old girl with symptoms of urinary frequency. The diagnosis was confirmed with pathology and she underwent clinical treatment with corticosteroids. More >

Anna R. Gagliardi¹, Neil Fleshner², Bernard Langer³, Hartley Stern³, Adalsteinn D. Brown⁴

Canadian Journal of Urology, Vol.12, No.5, pp. 2808-2815, 2005

Abstract Objectives: There is evidence of variation in both the processes and outcomes of prostate cancer care, resulting in possible harm to patients and increased costs to the health system. Care could be improved by first identifying critical, measurable indicators that correlate with quality of care. This work was conducted to develop indicators of prostate cancer care using a modified three-step Delphi approach.
Methods: A 17-member multidisciplinary panel reviewed potential indicators extracted from the medical literature through two consecutive rounds of rating followed by consensus discussion. The panel then prioritized the indicators selected in the previous two rounds.
Results:… More >

MARIA RAQUEL MARÇAL NATALI, SONIA LUCY MOLINARI, LUIZ CRISTIANO VALENTINI, MARCÍLIO HUBNER DE MIRANDA NETO.

BIOCELL, Vol.29, No.1, pp. 39-46, 2005, DOI:10.32604/biocell.2005.29.039

Abstract The purpose of this work was to analyze the morphoquantitative behavior of the neurons of the myenteric plexus, as well as the morphometry of the duodenal wall, in adult rats fed with normoproteic (22%) and hypoproteic (8%) rations, killed at the age of 345 days. For neuronal assessments duodenal wholemounts stained with the Giemsa method were used, and for the evaluation of the duodenal wall routine histological processing and staining with Hematoxilin-Eosin were employed. The means of the number of neurons in 80 microscopic fields (12.72 mm² ) and of the size of the neuronal cell More >