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  • Open Access

    ARTICLE

    Changes of inducible nitric oxide synthase in aortic cells during the development of hypertension: Effect of angiotensin II

    M. Cruzado, C. Castro, N. Risler, R. Miatello

    BIOCELL, Vol.26, No.1, pp. 61-67, 2002, DOI:10.32604/biocell.2002.26.061

    Abstract Nitric oxide (NO) generation by inducible nitric oxide synthase (iNOS) in the vascular smooth muscle cells (VSMC), may play a role in blood vessel tone regulation. Lipopolysaccharide (LPS) induced iNOS activity and subsequent nitrite production by cultured aortic VSMC, from SHR with an established chronic blood pressure elevation (adult SHR) or during the period preceding the development of hypertension (young SHR) and from age-matched normotensive Wistar (W) rats were compared. Angiotensin II (Ang II) effect was also evaluated. Both basal LPS-induced iNOS activity and nitrite accumulation were significantly lower in young SHR VSMC compared… More >

  • Open Access

    ARTICLE

    Wave Scattering by 2D Smooth Topographical Elastic Deformations Caused by a Point Blast Source

    Paulo Santos, Julieta António, António Tadeu1

    CMES-Computer Modeling in Engineering & Sciences, Vol.1, No.4, pp. 79-98, 2000, DOI:10.3970/cmes.2000.001.531

    Abstract This paper presents the three-dimensional scattering field obtained when 2D smooth topographical deformations are subjected to a dilatational point load placed at some point in the medium. The solution is formulated using boundary elements for a wide range of frequencies and spatially harmonic line loads, which are then used to obtain time series by means of (fast) inverse Fourier transforms into space-time. The topographical surface is modeled with a number of boundary elements, defined according to the excitation frequency of the harmonic source, and in such a way that the free surface can be discretized More >

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