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  • Open Access

    LETTER

    MESSAGE TO OUR READERS

    Leonard G. Gomella1, Timothy B. Hopkins2, Harry P. Koo3

    Canadian Journal of Urology, Vol.18, No.5, pp. 5933-5933, 2011

    Abstract This article has no abstract. More >

  • Open Access

    HOW I DO IT

    Management of pelvic organ prolapse

    Faisal Ahmed, Tiffany Sotelo

    Canadian Journal of Urology, Vol.18, No.6, pp. 6050-6053, 2011

    Abstract Symptomatic pelvic organ prolapse can afflict up to 10% of women. Urinary incontinence, voiding dysfunction or difficulty possibly related to bladder outlet obstruction are common symptoms. Infrequently hydronephrosis or defecatory dysfunction can be seen. The management of pelvic organ prolapse (POP) should start with adequate assessment of all pelvic floor complaints. If a patient is not symptomatic, surgical intervention is usually not indicated. While the use of a variety of graft materials are available today including porcine, dermal and synthetic grafts, that are used in some surgical approaches to pelvic organ prolapse, other more conservative More >

  • Open Access

    ABSTRACT

    Immunoassay of Human Immunoglobulin Using Quartz Crystal Microbalance

    Sheng D. Chao

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.17, No.2, pp. 33-34, 2011, DOI:10.3970/icces.2011.017.033

    Abstract We performed an immunoassay analysis using the Quartz Crystal Microbalance (QCM) biosensor to detect the specific binding reaction of the (Human IgG1)-(Anti-Human IgG1) protein pair. Both experimental and computational were used to study biomolecular binding reactions in microfluidic channels. We discussed the unsteady convective diffusion in the transportation tube and found that the distribution of the analyte concentration in the tube is strongly affected by the flow field. Due to this, large discrepancies between the simulations and experimental results were observed. We show that the conventional assumption of the uniform and steady analyte concentration used More >

  • Open Access

    ARTICLE

    The role of fl uorescence in situ hybridization assay for surveillance of non-muscle invasive bladder cancer

    Abhishek Karnwal1, Rose Venegas2, Brian Shuch1,3, Jeffrey Bassett1,3, Jacob Rajfer1,3, Richard Reznichek1,3

    Canadian Journal of Urology, Vol.17, No.2, pp. 5077-5081, 2010

    Abstract Objective: To compare the sensitivity and specificity of UroVysion fluorescence in situ hybridization assay (FISH) with cystoscopy and urine cytology in the surveillance of patients with documented non-muscle invasive bladder cancer (CIS, pTa and pT1).
    Methods: This retrospective study was done on a consecutive series of patients undergoing surveillance for non-muscle invasive bladder cancer. The results of FISH were analyzed with concurrent cystoscopy and urine cytology.
    Results: In all, 94 follow up visits from 59 patients were evaluated. The mean follow up was 52 months. FISH detected 30/48 recurrences of bladder cancer, as compared to 20/48 for cytology… More >

  • Open Access

    ARTICLE

    Lower urinary tract leiomyoma: is excision necessary?

    Deborah J. Lightner, Bryan C. Bruner

    Canadian Journal of Urology, Vol.17, No.4, pp. 5278-5282, 2010

    Abstract Introduction/objectives: Our objective was to review our experience with lower urinary tract leiomyomata to determine if presentation, exam and imaging allows for stratification of the treatment of this rare lesion.
    Materials and methods: A retrospective review of current practice was performed from the Mayo Clinic Rochester database identifying 13 female patients and 10 males from 1995-2008, focusing on the clinical presentation, cystoscopic findings, imaging and operative approaches.
    Results: Symptomatic patients had larger lesions, were more likely to be females, or had midline periurethral or bladder neck lesions. Cystoscopic findings were uniformly described as submucosal polypoid lesions without surrounding… More >

  • Open Access

    ARTICLE

    The Colossal Piezoresistive Effect in Nickel Nanostrand Polymer Composites and a Quantum Tunneling Model

    Oliver K. Johnson1, Calvin J. Gardner1, David T. Fullwood1, Brent L.Adams1, Nathan Hansen2, George Hansen2

    CMC-Computers, Materials & Continua, Vol.15, No.2, pp. 87-112, 2010, DOI:10.3970/cmc.2010.015.087

    Abstract A novel nickel nanostrand-silicone composite material at an optimized 15 vol% filler concentration demonstrates a dramatic piezoresistive effect with a negative gauge factor (ratio of percent change in resistivity to strain). The composite volume resistivity decreases in excess of three orders of magnitude at a 60% strain. The piezoresistivity does decrease slightly as a function of cycles, but not significantly as a function of time. The material's resistivity is also temperature dependent, once again with a negative dependence.
    The evidence indicates that nickel strands are physically separated by matrix material even at high volume fractions, and More >

  • Open Access

    ARTICLE

    Development beyond the gastrula stage and digestive organogenesis in the apple-snail Pomacea canaliculata (Architaenioglossa, Ampullariidae)

    E. KOCH1, B.C. WINIK2, A. CASTRO-VAZQUEZ1,3,*

    BIOCELL, Vol.33, No.1, pp. 49-65, 2009, DOI:10.32604/biocell.2009.33.049

    Abstract Development of Pomacea canaliculata from the gastrula stage until the first day after hatching is described. Trochophore embryos are developed after gastrulation, showing the prototroch as a crown of ciliated orange-brownish cells. However, no true veliger embryos are formed, since the prototroch does not fully develop into a velum. Afterward, the connection between the fore- and midgut is permeated and the midgut becomes full of the pink-reddish albumen, which is stored into a central archenteron’s lake, from where it is accumulated into the large cells forming the midgut wall (“giant cells”). Electron microscopy of giant cells… More >

  • Open Access

    ARTICLE

    Cell Cycle Modeling for Budding Yeast with Stochastic Simulation Algorithms

    Tae-Hyuk Ahn1, Layne T. Watson1,2, Yang Cao1,1, Clifford A. Shaffer1, William T. Baumann3

    CMES-Computer Modeling in Engineering & Sciences, Vol.51, No.1, pp. 27-52, 2009, DOI:10.3970/cmes.2009.051.027

    Abstract For biochemical systems, where some chemical species are represented by small numbers of molecules, discrete and stochastic approaches are more appropriate than continuous and deterministic approaches. The continuous deterministic approach using ordinary differential equations is adequate for understanding the average behavior of cells, while the discrete stochastic approach accurately captures noisy events in the growth-division cycle. Since the emergence of the stochastic simulation algorithm (SSA) by Gillespie, alternative algorithms have been developed whose goal is to improve the computational efficiency of the SSA. This paper explains and empirically compares the performance of some of these More >

  • Open Access

    ARTICLE

    Genotoxic effect of Physalis angulata L. (Solanaceae) extract on human lymphocytes treated in vitro

    RAQUEL ALVES DOS SANTOS1, TERESINHA ROSA CABRAL2, ISABEL ROSA CABRAL2, LUSÂNIA MARIA GREGGI ANTUNES3,4, CRISTIANE PONTES ANDRADE3, PLÍNIO CERQUEIRA DOS SANTOS CARDOSO1, MARCELO DE OLIVEIRA BAHIA2, CLAUDIA PESSOA5, JOSÉ LUIS MARTINS DO NASCIMENTO2, ROMMEL RODRÍGUEZ BURBANO2, CATARINA SATIE TAKAHASHI1,6

    BIOCELL, Vol.32, No.2, pp. 195-200, 2008, DOI:10.32604/biocell.2008.32.195

    Abstract Physalis angulata L (Solanaceae) is a medicinal plant from North of Brazil, whose different extracts and infusions are commonly used in the popular medicine for the treatment of malaria, asthma, hepatitis, dermatitis and rheumatism. However, the genotoxic effects of P. angulata on human cells is not well known. The main purpose of the present study was to evaluate the in vitro genotoxic effects of aqueous extract of P. angulata using the comet assay and the micronucleus assay in human lymphocytes provided from 6 healthy donors. Treatments with P. angulata extracts were performed in vitro in order to access the extent of More >

  • Open Access

    ABSTRACT

    Higher-Order Stress and Size Effects Due to Self Energy of Geometrically Necessary Dislocations

    N. Ohno1, D. Okumura1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.4, No.4, pp. 207-214, 2007, DOI:10.3970/icces.2007.004.207

    Abstract The self energy of geometrically necessary dislocations (GNDs) is considered to inevitably introduce the higher-order stress work-conjugate to slip gradient in single crystals. It is pointed out that this higher-order stress stepwise changes in response to in-plane slip gradient and thus directly influences the onset of initial yielding in polycrystals. The self energy of GNDs is then incorporated into the strain gradient theory of Gurtin (2002). The resulting theory is applied to model crystal grains of size D, leading to a D-1-dependent term with a coefficient determined by grain shape and orientation. It is thus More >

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