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  • Open Access

    ABSTRACT

    Higher-Order Stress and Size Effects Due to Self Energy of Geometrically Necessary Dislocations

    N. Ohno1, D. Okumura1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.4, No.4, pp. 207-214, 2007, DOI:10.3970/icces.2007.004.207

    Abstract The self energy of geometrically necessary dislocations (GNDs) is considered to inevitably introduce the higher-order stress work-conjugate to slip gradient in single crystals. It is pointed out that this higher-order stress stepwise changes in response to in-plane slip gradient and thus directly influences the onset of initial yielding in polycrystals. The self energy of GNDs is then incorporated into the strain gradient theory of Gurtin (2002). The resulting theory is applied to model crystal grains of size D, leading to a D-1-dependent term with a coefficient determined by grain shape and orientation. It is thus More >

  • Open Access

    ABSTRACT

    Supplement. 3 Workshop: Biology of Ampullariidae Conchological variation in Pomacea canaliculata and other South American Ampullariidae (Caenogastropoda, Architaenioglossa)

    ALEJANDRA L. ESTEBENET, PABLO R. MARTÍN, SILVANA BURELA

    BIOCELL, Vol.30, Suppl.S, pp. 329-335, 2006

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Disruption of T cell regulatory pathways is necessary for immunotherapeutic cure of T cell acute lymphoblastic leukemia in mice

    S. Fiorentino1,4, M. Chopin1, H. Dastot1, N. Boissel2, M. Reboul1, L. Legrès1, A. Janin1, P. Aplan3, F. Sigaux1, Armelle Regnault1

    European Cytokine Network, Vol.16, No.4, pp. 300-308, 2005

    Abstract Acute lymphoblastic leukemia (ALL) is the most common cancer in children. In recent years, the outcome has been globally improved by current therapies, but it remains poor in patients with high, persistent residual disease following the first course of chemotherapy, prompting evaluation of the possible beneficial effects of immunotherapy protocols. In this study, we hypothesized that the disruption of two immunoregulatory pathways controlling the auto-reactive T cell response might synergize with dendritic cell-based immunotherapy of the disease, which is considered to be poorly immunogenic. In this study, we used TAL1xLMO1 leukemia cells adoptively transferred in… More >

  • Open Access

    ARTICLE

    TNFα increases in vitro migration of human HPV18-positive SW756 cervical carcinoma cells

    K. HIDALGO1, I. G. ROJAS2, A. B. PENISSI3, M. I. RUDOLPH1

    BIOCELL, Vol.29, No.3, pp. 303-311, 2005, DOI:10.32604/biocell.2005.29.303

    Abstract TNFα has been associated with both, tumor survival and apoptosis. This cytokine is also involved in promoting cell migration during wound healing and tumorigenesis. SW756 is a HPV18-positive cervical carcinoma cell line, which has been used to study different mechanisms of cervical cancer progression. An in vitro assay of scratch wound healing onto monolayers of SW756 cells was used to assess the effect of TNFα on cell migration into a wound space. It was found that SW756 cells have the ability to migrate, but not proliferate in response to scratch wounding in a serum-free medium supplemented More >

  • Open Access

    ARTICLE

    A Stochastic Analysis of a Brownian Ratchet Model for Actin-Based Motility

    Hong Qian1

    Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 267-278, 2004, DOI:10.3970/mcb.2004.001.267

    Abstract In recent single-particle tracking (SPT) measurements on Listeria monocytogenes motility in cells [Kuo and McGrath (2000)], the actin-based stochastic dynamics of the bacterium movement has been analyzed statistically in terms of the mean-square displacement (MSD) of the trajectory. We present a stochastic analysis of a simplified polymerization Brownian ratchet (BR) model in which motions are limited by the bacterium movement. Analytical results are obtained and statistical data analyses are investigated. It is shown that the MSD of the stochastic bacterium movement is a monotonic quadratic function while the MSD for detrended trajectories is linear. Both the More >

  • Open Access

    ARTICLE

    Upper tract imaging after ureteroscopic holmium: YAG laser lithotripsy: when is it necessary?

    Darren T. Beiko, Kenneth A. Beasley, Pavin K. Koka, James D. Watterson, Linda Nott, John D. Denstedt, Hassan Razvi

    Canadian Journal of Urology, Vol.10, No.6, pp. 2062-2067, 2003

    Abstract Introduction/objective: Advances in ureteroscope design and refinements of ancillary instrumentation have resulted in an expanded role for ureteroscopy in the management of urinary calculi. Technological enhancements coupled with improved endourologic skills have also been associated with a reduction in procedural-related complications. Historically, postoperative imaging with ultrasound (U/S) or intravenous pyelogram (IVP) had been advocated to rule out persistent obstruction due to retained stone fragments or ureteral stricture. The purposes of this study were to evaluate the incidence of postoperative ureteral obstruction in a contemporary series of patients undergoing ureteroscopic holmium:YAG laser lithotripsy without basket extraction of… More >

  • Open Access

    ARTICLE

    A comparative analysis of rapid urine tests for the diagnosis of upper urinary tract malignancy

    D. Robert Siemens, Alvaro Morales, Brenda Johnston, Laurel Emerson

    Canadian Journal of Urology, Vol.10, No.1, pp. 1754-1758, 2003

    Abstract Objectives: To compare the effectiveness of two rapid urine tests fibrinogen / fibrin degradation products FDP (Aura Tek FDP, PerImmune Inc., Rockville, Maryland, USA) and bladder tumor antigen BTA (Bard BTA, Bard Canada Inc., Mississauga, Ontario, Canada) to urinary cytology in establishing the diagnosis of transitional cell carcinoma (TCC) in patients with suspected upper tract malignancy.
    Materials and methods: In a prospective study, urine samples were collected from 29 patients with abnormalities of the upper tracts highly suspicious for malignancy. Sensitivity and specificity of the BTA and FDP tests were determined and compared to those of cytology.… More >

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