Shi Ying*, Huang Jianjun†, Yi Xue*, Yu Shuwei*, Zhang Liyuan*, Wang Jie*, Cheng Lixian*
Oncology Research, Vol.25, No.9, pp. 1421-1430, 2017, DOI:10.3727/096504016X14826089198805
Abstract MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting
mRNAs for translational repression or degradation. In this study, we showed that the miR-133b expression
level was decreased while the Sirt1 mRNA expression level was increased in osteosarcoma tissue and cell lines.
A low expression of miR-133b was significantly associated with tumor size, distant metastasis, and advanced
clinical stage. In addition, osteosarcoma patients with a low miR-133b expression showed a worse prognosis
when compared to those with a high level of miR-133b expression. Thus, we identified Sirt1 as a More >
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