Cengiz Kirmaz¹, Ozlem Ozenturk Kirgiz², Papatya Bayrak¹, Ozge Yilmaz³, Seda Vatansever⁴, Kemal Ozbilgin⁴, Ece Onur⁵, Onur Celik⁶, Ayhan Sogut³, Gungor Ay⁷, Hasan Yuksel³

European Cytokine Network, Vol.22, No.1, pp. 15-23, 2011, DOI:10.1684/ecn.2011.0277

Abstract Background. Seasonal allergic rhinitis (SAR) is characterized by a helper T (Th)2 cell-mediated immune response at the target site. There is a relative Th1 and/or regulatory T (Treg) cell insufficiency in patients with SAR. It has been demonstrated that there is a change in the balance between these cells after allergen-specific immunotherapy (SIT), which is a curative treatment modality for this disease. However, there are few studies that evaluate the number and function of these cells in the inflammatory area after SIT treatment. Objective. We aimed to investigate the distribution of Th1, Th2 and Treg… More >

Shuguang Li

The International Conference on Computational & Experimental Engineering and Sciences, Vol.20, No.1, pp. 23-24, 2011, DOI:10.3970/icces.2011.020.023

Abstract Unit cells have been found as an empowering tool for the characterisations of modern composites. The author is honoured to have contributed to the establishment of a systematic methodology for the formulation of unit cells in the past decade through over a dozen of publications on this specific topic.
The formulation of a unit cell could start as if it was a trivial exercise, at least as sometimes perceived by some users, where casual treatments have been found as a result. However, it could soon become overwhelming in order to stand scrutiny and to deal with… More >

Knut Liseth¹, Malvin Sjo², Kristin Paulsen³, Øystein Bruserud^2,3, Elisabeth Ersvaer³

European Cytokine Network, Vol.21, No.1, pp. 40-49, 2010, DOI:10.1684/ecn.2009.0181

Abstract Previous studies of T cell reconstitution following allogeneic stem cell transplantation have described long-lasting T cell defects, including decreased levels of autocrine proliferating CD4+ T cells. However, T cell functions during the early phase of conditioning-induced, pre-engraftment pancytopenia have not been characterized previously. We used a whole blood assay to investigate T cell proliferation and cytokine release during the period of pre-engraftment cytopenia. The study included 13 acute leukemia patients receiving mye-loablative conditioning followed by transplantation of G-CSF-mobilised peripheral blood stem cells derived from HLA-matched family donors. Maximal proliferation and cytokine release could not be… More >

Johannes Nemeth^1,3, Heide-Maria Winkler¹, Franz Karlhofer², Nicole Selenko-Gebauer², Wolfgang Graninger¹, Stefan Winkler¹

European Cytokine Network, Vol.21, No.1, pp. 34-39, 2010, DOI:10.1684/ecn.2009.0182

Abstract Patients treated with tumor necrosis factor (TNF)-α-antagonizing medication are at increased risk of developing active tuberculosis (TB), brought about mainly by reactivation of latent infection. Thus, screening for latent TB infection (LTBI) prior to administration of anti-TNF-α-therapy is required. For a long time, the tuberculin skin test (TST) was the only means of diagnosing LTBI, however, interferon-gamma-release assays (IGRAs), are promising new tools. Fifty two patients with dermatological disorders were included prior to imple-mentation of anti-TNF-α therapy. Mycobacterium tuberculosis (MTB)-specific cytokine production, including interferon (IFN)-γ, TNF-α, interleukin (IL)-2 and IL-10, was measured in CD4⁺ and CD8⁺ T… More >

Yvonne M. Mueller, Peter D. Katsikis

European Cytokine Network, Vol.21, No.3, pp. 219-221, 2010, DOI:10.1684/ecn.2010.0198

Abstract Recent studies have shown that interleukin-15 (IL-15) is produced during acute HIV and SIVinfection, and may impact viremia and viral set point. This is further supported by the findings that administra-tion of IL-15 during acute SIV infection dramatically increases viral set point. Although the role of intrinsicIL-15 during chronic infection is much less defined, in vivo administration of IL-15 does not increase viral repli-cation in SIV-infected animals. Recent data also suggest that IL-15 acts, not only on CD8+ T cells and naturalkiller cells, but also on effector memory CD4+ T cells. IL-15 clearly expands very More >

Hala Faragalla^1,2, Sahar Al-Haddad^1,2, Robert Stewart³, George M Yousef^1,2

Canadian Journal of Urology, Vol.17, No.3, pp. 5219-5222, 2010

Abstract Background: Renal cell carcinoma (RCC) with multinucleated giant cells has been reported in the literature. Different types of multinucleated giant cells have been described, including the osteoclast-like giant cells, rhabdoid cells, syncytial giant cells and tumor multinucleated giant cells.
Results: We describe a unique case of a clear cell RCC with extensive giant cell component. Tumor giant cells were arranged in an alveolar pattern and formed more than 50% of the tumor. The rest of the tumor was a classic clear cell renal cell carcinoma. A rhabdoid component was also focally seen. The immunohistochemical profile of the… More >

Enrico Crivellato¹, Beatrice Nico², Domenico Ribatti²

European Cytokine Network, Vol.20, No.4, pp. 197-206, 2009, DOI:10.1684/ecn.2009.0167

Abstract Mast cells (MCs) are tissue leukocytes that are distributed throughout the major organs of the body. They are an important local source of preformed and newly synthesized angiogenic molecules. MCs have been linked both to inflammatory and tumor angiogenesis. Indeed, numerous solid tumors and hematological malignancies present MC-rich infiltrates, which are believed to contribute to the formation of a new vascular supply. In addition, angiogenesis and MC density have been shown to increase simultaneously with the pathological progression in many of such tumors. This review will focus on the angiogenic potential of MCs in human More >

Jean-Marc Schiano de Colella^1,2, Bernadette Barbarat¹, Ray Sweet⁴, Jean-Albert Gastaut², Daniel Olive^1,3, Regis T. Costello^1,2

European Cytokine Network, Vol.19, No.2, pp. 81-88, 2008, DOI:10.1684/ecn.2008.0125

Abstract Mature dendritic cells (DC) are efficient, antigen-presenting cells required for the stimulation of naive T lymphocytes. Many members of the tumour necrosis factor (TNF) receptor family are involved in DC maturation, such as Fas, CD40, OX40L, LIGHT (homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed by T lymphocytes) or RANK (receptor activator of NFjB), with different, but often overlapping effects. We focused our attention on RANK DC stimulation, since RANK ligand (RL) is expressed on activated T lymphocytes with different kinetic and… More >

LETTY MARCANO, INGRID CARRUYO, YUSMARY FERNÁNDEZ, XIOMARA MONTIEL, ZAIDA TORREALBA.

BIOCELL, Vol.30, No.2, pp. 259-267, 2006, DOI:10.32604/biocell.2006.30.259

Abstract The vanadium is a metal that presents great interest from the toxicological point of view, because of the numerous alterations that can take place in different biological systems. This work evaluated the capacity of vanadium accumulation and its correlation with genotoxic effects in root cells of Allium cepa L. The bulbs were cultivated in renovated filtered water each 24 h, at a temperature of 25 ± 0.5°C, in darkness and constant aeration. Treatments were carried out under the same experimental conditions, using water solutions of vanadium of 25, 50, 75 and 100μg/g for 0, 12, 24,… More >

D. H. Pahr¹, F.G. Rammerstorfer¹

CMES-Computer Modeling in Engineering & Sciences, Vol.12, No.3, pp. 229-242, 2006, DOI:10.3970/cmes.2006.012.229

Abstract Sandwich structures are efficient lightweight materials. Due to there design they exhibit very special failure modes such as global buckling, shear crimping, facesheet wrinkling, facesheet dimpling, and face/core yielding. The core of the sandwich is usually made of foams or cellular materials, e.g., honeycombs. Especially in the case of honeycomb cores the correlation between analytical buckling predictions and experiments might be poor (Ley, Lin, and Uy (1999)). The reason for this lies in the fact that analytical formulae typically assume a homogeneous core (continuous support of the facesheets). This work highlights problems of honeycomb core… More >