Muhammad Shoaib Arif^{1, *}, Ali Raza¹, Muhammad Rafiq², Mairaj Bibi³, Javeria Nawaz Abbasi³, Amna Nazeer³, Umer Javed⁴

CMC-Computers, Materials & Continua, Vol.62, No.1, pp. 61-77, 2020, DOI:10.32604/cmc.2020.08595

Abstract We are presenting the numerical simulations for the stochastic computer virus propagation model in this manuscript. We are comparing the solutions of stochastic and deterministic computer virus models. Outcomes of a threshold number R₀ hold in stochastic computer virus model. If R₀ < 1 then in such a condition virus controlled in the computer population while R₀ > 1 shows virus rapidly spread in the computer population. Unfortunately, stochastic numerical techniques fail to cope with large step sizes of time. The suggested structure of the stochastic non-standard finite difference technique can never violate the dynamical properties. On More >

Hatim Thaker, Saum Ghodoussipour, Mateen Saffarian, Akbar Ashrafi, Gus Miranda, Jie Cai, Anne K. Schuckman, Monish Aron, Mihir Desai, Inderbir S. Gill, Siamak Daneshmand, Hooman Djaladat

Canadian Journal of Urology, Vol.26, No.1, pp. 9654-9659, 2019

Abstract Introduction: To evaluate the reasons leading to an extended hospital stay (EHS) in patients undergoing radical cystectomy (RC) with postoperative enhanced recovery after surgery (ERAS) protocol.
Materials and methods: A total of 509 patients underwent RC and urinary diversion with ERAS between May 2012 and March 2017. The protocol includes no bowel preparation, early feeding, predominantly non-narcotic pain control, and μ opioid antagonists. Non-consenting/lost to follow-up patients, and those with non-urothelial carcinoma were excluded. We defined EHS as ≥ 5 postoperative days and compared the cohort to those with a length of stay (LOS) of ≤ 4… More >

Félix Couture^1,2,*, Stefano Polesello², Côme Tholomier^2,3, Helen Davis Bondarenko², Pierre I. Karakiewicz², Sebastiano Nazzani^4,5, Felix Preisser^5,6, Assaad El-Hakim², Kevin C. Zorn⁷

Canadian Journal of Urology, Vol.26, No.1, pp. 9644-9653, 2019

Abstract Introduction: Neurovascular bundle (NVB) preservation during robot-assisted radical prostatectomy (RARP) directly affects patient functional outcomes. Despite careful surgical planning, many NVB preservation techniques are changed intraoperatively from their preoperative plan. Our objective was to identify risk factors predicting intraoperative change in NVB preservation technique during RARP.
Materials and methods: Prospective data from 578 RARPs performed by a single surgeon between 2010 and 2017 at a tertiary care center. Side-specific NVB preservation technique was planned preoperatively. Surgical techniques were either complete nerve sparing (CNS), or incomplete nerve sparing (INS). Variables included age, tumor grade, prostate volume, number of… More >

Nirmish Singla¹, Jordon T. Walker¹, Solomon L. Woldu¹, Karen De La Fuente¹, Ellen Araj², Brandon Swartz², Payal Kapur^1,2, Claus G. Roehrborn¹

Canadian Journal of Urology, Vol.26, No.1, pp. 9634-9643, 2019

Abstract Introduction: To determine whether quantifying the proximity of positive prostate biopsy cores to the capsular edge may aid in identifying patients at risk for extracapsular extension (ECE) at the time of radical prostatectomy (RP).
Materials and methods: We reviewed a single-surgeon experience of 429 systematic transrectal prostate biopsies from 2010-2014. Marking ink was applied to the capsular edge ex vivo following specimen acquisition, and the proximity of cancer to the stained capsular edge was measured. Primary outcome was ECE at RP. Demographics, PSA, DRE findings, Gleason score, core location and involvement, and RP pathology were recorded. Predictors… More >

Jacqueline Zillioux¹, David Rapp¹, Luriel Smith-Harrison², Matthew Wang¹, Raymond Costabile¹

Canadian Journal of Urology, Vol.26, No.2, pp. 9720-9725, 2019

Abstract Introduction: To evaluate complications following urinary diversion for non-malignant conditions.
Materials and methods: We performed a retrospective review of patients undergoing urinary diversion for benign indications between 2000 and 2017. Data collected including patient demographic and clinical characteristics, surgical characteristics, and complications. Complications were graded using Clavien-Dindo classification and were categorized as early versus delayed (≤ versus > 90 day postoperatively). Logistic regression assessed for predictors of developing any postoperative complication.
Results: A total of 68 patients were identified for study analysis with median follow up of 24 (7-72) months. Sixty-eight percent and 25% of patients underwent diversion… More >

Andrew Salner¹, Ilene Staff², Rene I. Jahiel¹, Keith M. Bellizzi³, Alison Champagne², Joseph Tortora², Alison G. Wong³, Tara McLaughlin⁴, Joseph Wagner⁴

Canadian Journal of Urology, Vol.26, No.2, pp. 9708-9714, 2019

Abstract Introduction: We compared the return-to-work interval (RTWI) after radical retro-pubic prostatectomy (RRP) and robot-assisted laparoscopic prostatectomy (RALP) in men being treated for early-stage prostate cancer.
Materials and methods: We mailed a 28-item questionnaire to a random sample of 2,696 patients who either had RRP from 1995 to 2004 or RALP from 2004 to 2011.
Results: We received analyzable questionnaires from 315 patients; 178 had RALP and 137 had RRP. The median RTWI was shorter in the RALP group than in the RRP group (3 versus 4 weeks, p = .016). The percent of subjects who had not returned More >

Come Tholomier^1,2, Felix Couture^1,3, Khaled Ajib¹, Felix Preisser^4,5, Helen Davis Bondarenko¹, Cristina Negrean¹, Pierre Karakiewicz^1,4, Assaad El-Hakim⁶, Kevin C. Zorn¹

Canadian Journal of Urology, Vol.26, No.4, pp. 9843-9851, 2019

Abstract Introduction: Robotic-assisted radical prostatectomy (RARP) has grown to be the predominant global surgical approach to treat localized prostate cancer. However, there is still limited access to robotic technology and little data from Canadian cohorts. Herein, we report on our oncological and functional outcomes after 10 years of surgical experience.
Materials and methods: Prospective data from 1,034 RARP cases performed by two high-volume experienced surgeons at two academic centers were collected from October 2006 to June 2017. Preoperative characteristics, surgical, oncological, and functional outcomes were assessed up to 72 months postoperative.
Results: D’Amico risk distribution was 26.1%, 59.8%, and… More >

Mazen Alsinnawi¹, Jennifer Cullen^2,3,4, Lauren M. Hurwitz^2,3, Katherine E. Levie^2,3, John F. Burns¹, Inger L. Rosner^2,5, Timothy C. Brand^2,6, Sean Stroup^2,7, Joseph R. Sterbis^2,8, Kevin Rice^2,5, Galen Conti^2,3, Christopher R. Porter^1,2

Canadian Journal of Urology, Vol.26, No.4, pp. 9809-9820, 2019

Abstract Introduction: To assess the impact of primary and secondary therapies for high- and intermediate-risk prostate cancer on health-related quality of life (HRQoL).
Materials and methods: A prospective study was initiated in 2007 at Center for Prostate Disease Research Multicenter National Database sites. Longitudinal patterns in HRQoL from baseline (pre-treatment) to 5 years post-diagnosis were examined for patients with high- and intermediate-risk prostate cancer, treated by radical prostatectomy (RP) or external beam radiation therapy (EBRT). Change in HRQoL was modeled using linear regression models fit with generalized estimating equations. The probability of maintaining HRQoL was compared between patients… More >

Kyle W. Law¹, Dean S. Elterman², Hannes Cash³, Enrique Rijo⁴, Bilal Chughtai⁵, Vincent Misrai⁶, Kevin C. Zorn¹

Canadian Journal of Urology, Vol.26, No.5, pp. 9963-9972, 2019

Abstract For men experiencing lower urinary tract symptoms (LUTS) refractory to medical therapy, there have been numerous developments in the treatment options offered for benign prostatic hyperplasia (BPH) in the recent years. Transurethral resection of the prostate (TURP) has remained the reference standard for men with prostates sized 30 cc-80 cc, while open prostatectomy is universally guidelines-recommended in the absence of enucleation, for men with prostates larger than 80 cc-100 cc. While these techniques are effective, they have the potential for bleeding complications requiring transfusions, electrolyte abnormalities such as TURP syndrome, and often require prolonged hospitalization.… More >

Kristen E. Gurtner¹, Danica N. May¹, Jay D. Raman², Kathleen Lata-Arias¹, Daniel J. Canter¹

Canadian Journal of Urology, Vol.26, No.5, pp. 9931-9937, 2019

Abstract Introduction: There has been growing use of adrenalectomy as a potentially curative treatment option for patients with oligometastatic disease to the adrenal gland. We sought to compare the perioperative outcomes of patients undergoing isolated adrenalectomy in the setting of disseminated cancer using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. Furthermore, we examined the impact of performing surgical sub-specialty on outcomes.
Materials and methods: Data from the ACS-NSQIP database was obtained for patients between 2011 and 2016 who underwent adrenalectomy. Patients were stratified by the presence or absence of disseminated cancer. Univariate and… More >