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  • Open Access

    ARTICLE

    Soil Metagenomics: new challenges and biotechnological opportunities

    Hernández-León R, I Velázquez-Sepúlveda, MC Orozco-Mosqueda, G Santoyo

    Phyton-International Journal of Experimental Botany, Vol.79, pp. 133-139, 2010, DOI:10.32604/phyton.2010.79.133

    Abstract Soil is a complex system that includes a great number and diversity of microorganisms. Until recently, only a small percentage of the bioma was known and could be studied. Currently, it is possible to have a deeper knowledge of all that unknown genomic material with the development of new tools, like metagenomics. New molecules have been discovered with various biotechnological applications, and knowledge of the diverse microbiological interactions in several environments, some of them with extreme life conditions, is much higher. We analyze the most recent literature in the field of metagenomics in this study, More >

  • Open Access

    ARTICLE

    Transient coupled thermoelastic crack analysis in functionally graded materials1

    A.V. Ekhlakov2, O.M. Khay2, Ch. Zhang2, J. Sladek3, V. Sladek3

    Structural Durability & Health Monitoring, Vol.6, No.3&4, pp. 329-350, 2010, DOI:10.3970/sdhm.2010.006.329

    Abstract In this paper, transient crack analysis in two-dimensional, isotropic, continuously non-homo -ge -neous and linear elastic functionally graded materials is presented. A boundary-domain element method based on boundary-domain integral representations is developed. The Laplace-transform technique is utilized to eliminate the dependence on time. Laplace-transformed fundamental solutions of linear coupled thermoelasticity for isotropic, homogeneous and linear elastic solids are applied to derive boundary-domain integral equations. The numerical implementation is performed by using a collocation method for the spatial discretization. The time-dependent numerical solutions are obtained by the Stehfest's inversion algorithm. For an edge crack in a More >

  • Open Access

    ABSTRACT

    Computational techniques applied to design ventilation system for the preservation of the tombs of the valley of Kings, Luxor

    Essam E Khalil1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.15, No.2, pp. 47-56, 2010, DOI:10.3970/icces.2010.015.047

    Abstract The cultural heritage left by the Egyptian Pharaohs in the tombs of the Valley of the Kings represents some of the key elements of the Egyptian cultural and tourism wealth and standing monuments demonstrating the wealth and technology of the pharaohs. These tombs were prepared to bury the Kings' mummies and artifacts for eternal life. Many of the wall paintings identifying the various ancient rituals and life style are in good conditions as the tombs were only recently opened to the public and resulted, in many instances, to dramatic deterioration of the wall paintings due More >

  • Open Access

    ARTICLE

    Cancer Cell(s) Cycle Sequencing Reveals Universal Mechanisms of Apoptosis

    R. M. Ardito Marretta*, F. Ales

    Molecular & Cellular Biomechanics, Vol.7, No.4, pp. 225-266, 2010, DOI:10.3970/mcb.2010.007.225

    Abstract In this paper, cell cycle in higher eukaryotes and their molecular networks signals both inG1/SandG2/Mtransitions are replicatedin silico. Biochemical kinetics, converted into a set of differential equations, and system control theory are employed to design multi-nested digital layers to simulate protein-to-protein activation and inhibition for cell cycle dynamics in the presence of damaged genomes. Sequencing and controlling the digital process of four micro-scale species networks (p53/Mdm2/DNA damage, p21mRNA/cyclin-CDK complex, CDK/CDC25/wee1/ SKP2/APC/CKI and apoptosis target genes system) not only allows the comprehension of the mechanisms of these molecule interactions but paves the way for unraveling the… More >

  • Open Access

    ARTICLE

    The Hybrid Boundary Node Method Accelerated by Fast Multipole Expansion Technique for 3D Elasticity

    Qiao Wang1, Yu Miao1,2, Junjie Zheng1

    CMES-Computer Modeling in Engineering & Sciences, Vol.70, No.2, pp. 123-152, 2010, DOI:10.3970/cmes.2010.070.123

    Abstract In this paper, a fast formulation of the hybrid boundary node method (Hybrid BNM) for solving 3D elasticity is presented. Coupling modified variational principle with the Moving Least Squares (MLS) approximation, the Hybrid BNM only requires discrete nodes constructed on the surface of a domain. The preconditioned GMERS is employed to solve the resulting system of equations. At each iteration step of the GMERS, the matrix-vector multiplication is accelerated by the fast multipole method (FMM). The fundamental solution of three-dimensional elasticity problem is expanded in terms of series. An oct-tree data structure is adopted to More >

  • Open Access

    ARTICLE

    Explicit Solutions of Stresses for a Three-Phase Elliptic Inclusion Problem Subject to a Remote Uniform Load

    Ching Kong Chao1,2, Chin Kun Chen3, Fu Mo Chen4

    CMES-Computer Modeling in Engineering & Sciences, Vol.69, No.2, pp. 119-142, 2010, DOI:10.3970/cmes.2010.069.119

    Abstract A general solution to a three-phase elliptic inclusion problem subjected to a remote uniform load is provided in this paper. Analysis of the present elasticity problem is rather tedious due to the presence of material inhomogeneities and complex geometric configurations. Based on the technique of conformal mapping and the method of analytical continuation in conjunction with the alternating technique, the general expressions of the displacement and stresses in each layer medium are derived explicitly in a series form. The effects of the material combinations and geometric configurations on the interfacial stresses are discussed in detail More >

  • Open Access

    ARTICLE

    Shape Optimization in Time-Dependent Navier-Stokes Flows via Function Space Parametrization Technique1

    Zhiming Gao2, Yichen Ma3

    CMES-Computer Modeling in Engineering & Sciences, Vol.66, No.2, pp. 135-164, 2010, DOI:10.3970/cmes.2010.066.135

    Abstract Shape optimization technique has an increasing role in fluid dynamics problems governed by distributed parameter systems. In this paper, we present the problem of shape optimization of two dimensional viscous flow governed by the time dependent Navier-Stokes equations. The minimization problem of the viscous dissipated energy was established in the fluid domain. We derive the structure of continuous shape gradient of the cost functional by using the differentiability of a saddle point formulation with a function space parametrization technique. Finally a gradient type algorithm with mesh adaptation and mesh movement strategies is successfully and efficiently More >

  • Open Access

    ARTICLE

    An Improved Unsplit and Convolutional Perfectly Matched Layer Absorbing Technique for the Navier-Stokes Equations Using Cut-Off Frequency Shift

    Roland Martin1, Carlos Couder-Castaneda1

    CMES-Computer Modeling in Engineering & Sciences, Vol.63, No.1, pp. 47-78, 2010, DOI:10.3970/cmes.2010.063.047

    Abstract We develop an unsplit convolutional perfectly matched layer (CPML) technique to absorb efficiently compressible viscous flows and their related supersonic or subsonic regimes at the outer boundary of a distorted computational domain. More particularly subsonic outgoing flows or subsonic wall-boundary layers close to the PML are well absorbed, which is difficult to obtain without creating numerical instabilities over long time periods. This new PML (CPML) introduces the calculation of auxiliary memory variables at each time step and allows an unsplit formulation of the PML. Damping functions involving a high shift in the frequency domain allow… More >

  • Open Access

    ARTICLE

    Slow Motion of a General Axisymmetric Slip Particle Along Its Axis of Revolution and Normal to One or Two Plane Walls

    Huan J. Keh1, Yu C. Chang2

    CMES-Computer Modeling in Engineering & Sciences, Vol.62, No.3, pp. 225-254, 2010, DOI:10.3970/cmes.2010.062.225

    Abstract A theoretical study of the Stokes flow caused by a rigid particle of revolution translating axisymmetrically perpendicular to two parallel plane walls at an arbitrary position between them in a viscous fluid, which may slip at the particle surface, is presented. A method of distribution of a set of spherical singularities along the axis of revolution within a prolate particle or on the fundamental plane within an oblate particle is used to find the general solution of the fluid velocity field that satisfies the boundary conditions at the plane walls and at infinity. The slip… More >

  • Open Access

    ARTICLE

    A Finite Element enrichment technique by the Meshless Local Petrov-Galerkin method

    M. Ferronato1, A. Mazzia1, G. Pini1

    CMES-Computer Modeling in Engineering & Sciences, Vol.62, No.2, pp. 205-224, 2010, DOI:10.3970/cmes.2010.062.205

    Abstract In the engineering practice meshing and re-meshing complex domains by Finite Elements (FE) is one of the most time-consuming efforts. Meshless methods avoid this task but are computationally more expensive than standard FE. A somewhat natural improvement can be attempted by combining the two techniques with the aim at emphasizing the respective merits. The present work describes a FE enrichment by the Meshless Local Petrov-Galerkin (MLPG) method. The basic idea is to add a limited number of moving MLPG points over a fixed coarse FE grid, in order to improve the solution accuracy in specific More >

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