Nebojsa Ladjevic1,4, Otas Durutovic2,4, Ivana Likic-Ladjevic4,
Natasa Lalic3, Ana Mimic1, Natasa Dencic1,
Svetlana Sreckovic1, Zoran Dzamic2, Milan Terzic4,
Aleksandar Vuksanovic2,4, Dragica Milenkovic-Petronic2,4
Canadian Journal of Urology, Vol.20, No.6, pp. 7021-7027, 2013
Abstract Introduction: Inflammation plays a key role in the development of benign prostatic hyperplasia. Prostaglandin E2 (PGE2) is an important inflammation factor found in enlarged prostatic tissue that can be the main cause of inflammatory pain. The aim of this study was to investigate whether epidural anesthesia can block the negative effects of prostaglandin mediators during prostate surgery.
Materials and methods: The study included 60 patients who underwent open prostatectomy. All patients were randomly allocated to one of two study groups. The first group received general anesthesia and the second group a combination of general and epidural anesthesia.… More >