Nirmish Singla¹, Jordon T. Walker¹, Solomon L. Woldu¹, Karen De La Fuente¹, Ellen Araj², Brandon Swartz², Payal Kapur^1,2, Claus G. Roehrborn¹

Canadian Journal of Urology, Vol.26, No.1, pp. 9634-9643, 2019

Abstract Introduction: To determine whether quantifying the proximity of positive prostate biopsy cores to the capsular edge may aid in identifying patients at risk for extracapsular extension (ECE) at the time of radical prostatectomy (RP).
Materials and methods: We reviewed a single-surgeon experience of 429 systematic transrectal prostate biopsies from 2010-2014. Marking ink was applied to the capsular edge ex vivo following specimen acquisition, and the proximity of cancer to the stained capsular edge was measured. Primary outcome was ECE at RP. Demographics, PSA, DRE findings, Gleason score, core location and involvement, and RP pathology were recorded. Predictors… More >

Jacqueline Zillioux¹, David Rapp¹, Luriel Smith-Harrison², Matthew Wang¹, Raymond Costabile¹

Canadian Journal of Urology, Vol.26, No.2, pp. 9720-9725, 2019

Abstract Introduction: To evaluate complications following urinary diversion for non-malignant conditions.
Materials and methods: We performed a retrospective review of patients undergoing urinary diversion for benign indications between 2000 and 2017. Data collected including patient demographic and clinical characteristics, surgical characteristics, and complications. Complications were graded using Clavien-Dindo classification and were categorized as early versus delayed (≤ versus > 90 day postoperatively). Logistic regression assessed for predictors of developing any postoperative complication.
Results: A total of 68 patients were identified for study analysis with median follow up of 24 (7-72) months. Sixty-eight percent and 25% of patients underwent diversion… More >

Andrew Salner¹, Ilene Staff², Rene I. Jahiel¹, Keith M. Bellizzi³, Alison Champagne², Joseph Tortora², Alison G. Wong³, Tara McLaughlin⁴, Joseph Wagner⁴

Canadian Journal of Urology, Vol.26, No.2, pp. 9708-9714, 2019

Abstract Introduction: We compared the return-to-work interval (RTWI) after radical retro-pubic prostatectomy (RRP) and robot-assisted laparoscopic prostatectomy (RALP) in men being treated for early-stage prostate cancer.
Materials and methods: We mailed a 28-item questionnaire to a random sample of 2,696 patients who either had RRP from 1995 to 2004 or RALP from 2004 to 2011.
Results: We received analyzable questionnaires from 315 patients; 178 had RALP and 137 had RRP. The median RTWI was shorter in the RALP group than in the RRP group (3 versus 4 weeks, p = .016). The percent of subjects who had not returned More >

Come Tholomier^1,2, Felix Couture^1,3, Khaled Ajib¹, Felix Preisser^4,5, Helen Davis Bondarenko¹, Cristina Negrean¹, Pierre Karakiewicz^1,4, Assaad El-Hakim⁶, Kevin C. Zorn¹

Canadian Journal of Urology, Vol.26, No.4, pp. 9843-9851, 2019

Abstract Introduction: Robotic-assisted radical prostatectomy (RARP) has grown to be the predominant global surgical approach to treat localized prostate cancer. However, there is still limited access to robotic technology and little data from Canadian cohorts. Herein, we report on our oncological and functional outcomes after 10 years of surgical experience.
Materials and methods: Prospective data from 1,034 RARP cases performed by two high-volume experienced surgeons at two academic centers were collected from October 2006 to June 2017. Preoperative characteristics, surgical, oncological, and functional outcomes were assessed up to 72 months postoperative.
Results: D’Amico risk distribution was 26.1%, 59.8%, and… More >

Mazen Alsinnawi¹, Jennifer Cullen^2,3,4, Lauren M. Hurwitz^2,3, Katherine E. Levie^2,3, John F. Burns¹, Inger L. Rosner^2,5, Timothy C. Brand^2,6, Sean Stroup^2,7, Joseph R. Sterbis^2,8, Kevin Rice^2,5, Galen Conti^2,3, Christopher R. Porter^1,2

Canadian Journal of Urology, Vol.26, No.4, pp. 9809-9820, 2019

Abstract Introduction: To assess the impact of primary and secondary therapies for high- and intermediate-risk prostate cancer on health-related quality of life (HRQoL).
Materials and methods: A prospective study was initiated in 2007 at Center for Prostate Disease Research Multicenter National Database sites. Longitudinal patterns in HRQoL from baseline (pre-treatment) to 5 years post-diagnosis were examined for patients with high- and intermediate-risk prostate cancer, treated by radical prostatectomy (RP) or external beam radiation therapy (EBRT). Change in HRQoL was modeled using linear regression models fit with generalized estimating equations. The probability of maintaining HRQoL was compared between patients… More >

Kyle W. Law¹, Dean S. Elterman², Hannes Cash³, Enrique Rijo⁴, Bilal Chughtai⁵, Vincent Misrai⁶, Kevin C. Zorn¹

Canadian Journal of Urology, Vol.26, No.5, pp. 9963-9972, 2019

Abstract For men experiencing lower urinary tract symptoms (LUTS) refractory to medical therapy, there have been numerous developments in the treatment options offered for benign prostatic hyperplasia (BPH) in the recent years. Transurethral resection of the prostate (TURP) has remained the reference standard for men with prostates sized 30 cc-80 cc, while open prostatectomy is universally guidelines-recommended in the absence of enucleation, for men with prostates larger than 80 cc-100 cc. While these techniques are effective, they have the potential for bleeding complications requiring transfusions, electrolyte abnormalities such as TURP syndrome, and often require prolonged hospitalization.… More >

Kristen E. Gurtner¹, Danica N. May¹, Jay D. Raman², Kathleen Lata-Arias¹, Daniel J. Canter¹

Canadian Journal of Urology, Vol.26, No.5, pp. 9931-9937, 2019

Abstract Introduction: There has been growing use of adrenalectomy as a potentially curative treatment option for patients with oligometastatic disease to the adrenal gland. We sought to compare the perioperative outcomes of patients undergoing isolated adrenalectomy in the setting of disseminated cancer using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. Furthermore, we examined the impact of performing surgical sub-specialty on outcomes.
Materials and methods: Data from the ACS-NSQIP database was obtained for patients between 2011 and 2016 who underwent adrenalectomy. Patients were stratified by the presence or absence of disseminated cancer. Univariate and… More >

Ahmad N. Alzubaidi¹, Kenneth G. Nepple¹, Annah Vollstedt¹, Laila Dahmoush³, Deqin Ma³, Michael D. Henry^1,2,3,4, James A. Brown^1,4

Canadian Journal of Urology, Vol.26, No.6, pp. 10054-10060, 2019

Abstract Introduction: Dystroglycan (DG) is a cell surface receptor for extracellular matrix proteins involved in tissue mechanical stability and matrix organization. Initial work has demonstrated that alpha-DG expression is decreased in many types of adenocarcinoma, including prostate, and potentially associated with the development of metastatic disease. However, the consistency between prostate and lymph node alpha-DG staining has not been previously reported. Additionally, identification of an immunohistochemical marker associated with prostate cancer grade, stage, need for adjuvant or salvage therapy, and mortality would have potential clinical value.
Materials and methods: Node-positive, margin-negative radical prostatectomy specimens from a single institution… More >

Alexis Wang¹, Charles F. Polotti², Shu Wang¹, Sammy Elsamra^2,*, Mohummad Minhaj Siddiqui^1,*

Canadian Journal of Urology, Vol.26, No.6, pp. 10033-10038, 2019

Abstract Introduction: Robotic cystectomy with intracorporeal urinary diversion (RCID) is a technically challenging procedure. It is understood that this approach has a learning curve; however, limited studies have characterized this learning curve. The cumulative sum (CUSUM) method plots the learning curve. The aim of this study was to use the CUSUM approach to investigate the number of cases required to reach a consistent, desired performance level for RCID.
Materials and methods: A retrospective study of the first 27 and 28 RCID cases performed by two new fellowship-trained faculty at two separate institutions from November 2014 to January 2018… More >

JALPA V. CHOPDA, DHARMESH B. SANKHAVARA, JIGNESH P. PATEL, P. H. PARSANIA^*

Journal of Polymer Materials, Vol.36, No.1, pp. 101-109, 2019, DOI:10.32381/JPM.2019.36.01.8

Abstract The epoxy resin (EMBHBC) of (2E,6E)-bis (4-hydroxybenzylidene)-4-methyl cyclohexanone (MBHBC) was synthesized by condensing 0.5 mol MBHBC and 2.5 mol epichlorohydrin in 500 mL isopropyl alcohol as a solvent and 1.0 mol NaOH in 50 mL water as a catalyst at 80°C for 3 h. The structure of EMBHBC was supported by UV-Vis, FTIR, ¹ HNMR and ¹³CNMR spectroscopic techniques. Molecular weights and molecular weight distribution of EMBHBC were determined by gel permeation chromatography. DSC thermogram of EMBHC showed one endothermic transition (95.9°C) and two exothermic transitions (317.7°C and 382.2°C) due to melting and decomposition transitions, respectively. More >