John S. Lam¹, Alain C. Borczuk², John R. Franklin¹

Canadian Journal of Urology, Vol.10, No.6, pp. 2074-2076, 2003

Abstract Malignant Leydig cell tumor (LCT) of the testis are extremely rare and account for less than 0.2% of all testicular cancers. Testicular tumors of all histological types rarely occur in African American men. The authors describe a rare case of an advanced stage malignant LCT arising from the testicle of an African American man at the young age of 35, who presented with hemoptysis and a productive cough. Clinical features and treatment of Leydig cell tumor of the testis are discussed. More >

Alan So, S. Larry Goldenberg, Martin E. Gleave

Canadian Journal of Urology, Vol.10, No.6, pp. 2040-2050, 2003

Abstract Since its discovery in 1979, serum PSA has revolutionized how physicians manage men with prostate cancer. PSA screening, although currently under much debate, has been recommended by most North American medical bodies, including the Canadian Urological Association, to be performed as a shared-decision making process after discussing with patients the pros and cons of treatment. Although most commonly thought of as a screening tool, serum PSA has also been used to predict tumor volume, stage and prognosis in patients before and after treatment. In this review, we examine PSA testing and its effectiveness in the More >

Simon Tanguay

Canadian Journal of Urology, Vol.10, No.1, pp. 1767-1767, 2003

Abstract This article has no abstract. More >

M. S. Deshpande, J. N. Kulkarni

Canadian Journal of Urology, Vol.10, No.1, pp. 1770-1771, 2003

Abstract Testicular metastasis presenting as a testicular mass is an extremely rare condition. There are only nine previously reported cases where testicular mass was the first clinical manifestation of underlying malignancy. Here we report a case of metastatic mucin secreting adenocarcinoma in testis presenting as a testicular mass with unknown primary. We have given a brief review of literature about the spread of tumor to testes. More >

Abdullatif Hussain, Denis H. Hosking

Canadian Journal of Urology, Vol.10, No.1, pp. 1764-1766, 2003

Abstract Ultrasound is recognized as a valuable method of detecting testicular masses. Rarely, ultrasound will detect a testicular mass that was not clinically suspected. We present the case of a 43-year old man who presented with an unsuspected testicular mass detected by ultrasound. He underwent inguinal orchiectomy. The pathology showed a Leydig Cell tumor with cytological atypia. A review of the literature suggests that most incidentally discovered testicular masses are tumors, but there is disagreement as to whether they are usually benign or malignant. In view of the fact that many of these lesions are benign, More >

D. Robert Siemens, Alvaro Morales, Brenda Johnston, Laurel Emerson

Canadian Journal of Urology, Vol.10, No.1, pp. 1754-1758, 2003

Abstract Objectives: To compare the effectiveness of two rapid urine tests fibrinogen / fibrin degradation products FDP (Aura Tek FDP, PerImmune Inc., Rockville, Maryland, USA) and bladder tumor antigen BTA (Bard BTA, Bard Canada Inc., Mississauga, Ontario, Canada) to urinary cytology in establishing the diagnosis of transitional cell carcinoma (TCC) in patients with suspected upper tract malignancy.
Materials and methods: In a prospective study, urine samples were collected from 29 patients with abnormalities of the upper tracts highly suspicious for malignancy. Sensitivity and specificity of the BTA and FDP tests were determined and compared to those of cytology.… More >

Thomas E. Ahlering, Kimberly S. Thayer, Dilshad Sumnani, Regina M. Hovey, Douglas W. Skarecky

Canadian Journal of Urology, Vol.10, No.1, pp. 1749-1753, 2003

Abstract Objective: A community-based study of 2119 men in Olmsted County reported that median peak urinary flow rates (PFR)s and voided volumes decrease steadily after age 40. We wanted to study how removal of the prostate via radical prostatectomy (RRP) would effect age-related reduction of PFRs and voided volumes.
Methods: One hundred men 1-9 years following RRP were evaluated for PFR, voided volume, post void residual, and AUA symptom score.
Results: Following removal of the prostate the mean PFR was 26.6 +/- 11 cc/sec and the mean voided volume was 345 +/- 174 cc. Analysis of PFR and voided… More >

Vladimir Mouraviev, Martin E. Gleave

Canadian Journal of Urology, Vol.10, No.1, pp. 1737-1742, 2003

Abstract Objective: To review the careers of two urologists among Nobel Prize-winners in medicine, W. Forssmann and C.H. Huggins, and the significance of their contributions.
Material and methods: Investigation was performed based on analysis of collected findings from the biographies of laureates, their scientific publications and the Nobel archive database.
Results: Review revealed that of the 175 scientists and physicians who received the Nobel Prize, just over one half (94) held an MD degree while the remainder were PhD’s or other degrees. Of the 94 MD-degreed physicians nine (9.4%) were surgeons. Two of these laureates were urologists - Drs.… More >

LUZMARINA HERNANDES*, LUCIENI CRISTINA MARQUES DA SILVA PEREIRA*, ELIANA PARISI ALVARES**

BIOCELL, Vol.27, No.3, pp. 347-351, 2003, DOI:10.32604/biocell.2003.27.347

Abstract The enteric nervous system plays a role on the stimulation of secretory cells of intestinal epithelia. We have demonstrated that ablation of ENS stimulates epithelial cell proliferation. As goblet cells are important constituents of the epithelial sheet, it is mandatory to investigate separately this cell type. The myenteric plexus of the ileum of rats in postnatal development was partially removed by the serosal application of benzalkonium chloride (BAC). Three groups of animals were used: those where BAC application was at 13 days and sacrifice was at 15 (13/28-day-old) or 23 days after treatment (13/36-day-old), and More >

Lidia M. Lopez*, Marta Dubin**, Patricia H. Carrizo**, Mario H. Burgos***, Amanda Pellegrino De Iraldi*, Andrés O. M. Stoppani**

BIOCELL, Vol.27, No.2, pp. 213-224, 2003, DOI:10.32604/biocell.2003.27.213

Abstract CG 10-248 (3,4-dihydro-2,2-dimethyl-9-chloro-2H-naphtho[1,2b]pyran- 5,6-dione; CG-NQ), a β-lapachone analogue, modified the ultrastructure of rat hepatocytes, as demonstrated by light and electron microscopy. After 4 h incubation with 100 µM CG-NQ, the following effects were observed: (a) nuclear chromatin condensation; (b) chromatin fragmentation; (c) displacement of mitochondria, concentrated around the nucleus; (d) disruption or expansion of mitochondrial outer or inner membranes, respectively; (e) displacement and alteration of endoplasmic reticulum (rough and smooth); (f) decrease of microvilli; (g) blebbing of plasma membrane and production of apoptotic bodies formed by folding of plasma membrane fragments around mitochondria or peroxysomes; More >