Xiongwei Cui, Yunchao Wang, Qiang Wei^*

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 4939-4959, 2025, DOI:10.32604/cmc.2025.063592 - 19 May 2025

Abstract The development of the Internet of Things (IoT) has brought convenience to people’s lives, but it also introduces significant security risks. Due to the limitations of IoT devices themselves and the challenges of re-hosting technology, existing fuzzing for IoT devices is mainly conducted through black-box methods, which lack effective execution feedback and are blind. Meanwhile, the existing static methods mainly rely on taint analysis, which has high overhead and high false alarm rates. We propose a new directed fuzz testing method for detecting bugs in web service programs of IoT devices, which can test IoT… More >

Giuseppe Carota¹, Lucia Di Pietro^2,3, Vincenzo Cardaci⁴, Anna Privitera^1,2, Francesco Bellia¹, Valentina Di Pietro⁵, Giuseppe Lazzarino¹, Barbara Tavazzi⁶, Angela Maria Amorini¹, Giacomo Lazzarino⁶, Giuseppe Caruso^6,7,*

BIOCELL, Vol.49, No.4, pp. 563-578, 2025, DOI:10.32604/biocell.2025.062176 - 30 April 2025

Abstract Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous peptide widely distributed in excitable tissues, such as the heart and brain. Over the years, several beneficial effects of carnosine have been discussed well in scientific literature. In particular, this dipeptide is well-known for its antioxidant, anti-inflammatory, and anti-aggregation activities. It is of great interest in the context of numerous systemic and neurodegenerative diseases, besides performing important “side activities” such as metal chelation and pH-buffering. Despite a plethora of preclinical and clinical data supporting carnosine’s therapeutic potential, researchers are still searching for new pharmacological targets that better highlight More >

HYUNG SEOK KIM^*

Oncology Research, Vol.33, No.5, pp. 995-1000, 2025, DOI:10.32604/or.2025.060616 - 18 April 2025

Abstract The discovery of glycosylated RNA molecules, known as glycoRNAs, introduces a novel dimension to cellular biology. This commentary explores the transformative findings surrounding glycoRNAs, emphasizing their unique roles in cancer progression and the therapeutic opportunities they present. GlycoRNAs, through interactions with lectins and immune receptors, may contribute to tumor immune evasion. Moreover, the therapeutic potential of this emerging knowledge includes interventions targeting glycoRNA synthesis and modulation of associated signaling pathways. By highlighting these critical insights, this commentary aims to encourage the development of innovative strategies that could improve cancer prognosis and treatment. More >

ZHIZHENG ZHANG^1,#, TAO LI^2,#, YUAN LI³, XI WANG⁴, HAO LIU⁵, XINYU SHEN⁵, ANN XU⁶, TIANSONG XIA^1,*, BO XU^7,*

Oncology Research, Vol.33, No.4, pp. 811-819, 2025, DOI:10.32604/or.2024.050505 - 19 March 2025

Abstract Background: Breast cancer is a prevalent malignant tumor affecting females, with treatment options including surgery, radiotherapy, chemotherapy, and endocrine therapy. Methods: This review synthesizes existing literature on breast cancer stem cells and their applications in breast cancer treatment. PubMed, Web of Science, and other relevant databases were systematically searched using keywords such as “breast cancer stem cells,” “immunotherapy,” “gene therapy,” and “cell therapy.” Studies published in English were included, and their findings were analyzed to provide insights into the characteristics and therapeutic potential of breast cancer stem cells. Results: Breast cancer stem cells exhibit unique properties More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.3, pp. 735-735, 2025, DOI:10.32604/or.2024.056907 - 28 February 2025

Abstract This article has no abstract. More >

JUNWEI DU, QIANG ZHANG, JING ZHANG, MAIERDANJIANG MAIHEMUTI, HAIYANG HE, RENBING JIANG^*

Oncology Research, Vol.33, No.2, pp. 357-367, 2025, DOI:10.32604/or.2024.050878 - 16 January 2025

Abstract Objectives: Melanoma is a highly aggressive and metastatic form of cancer, and the role of exosomal microRNAs (miRNAs) in its progression remains largely unexplored. This study aimed to investigate the effects of melanoma cell-derived exosomal miR-424-5p on angiogenesis and its underlying mechanisms. Methods: Exosomes were isolated from melanoma cell lines A375 and A2058, and their effects on the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs) were examined. The interaction between miR-424-5p and its target gene, large tumor suppressor kinase 2 (LATS2), was analyzed using luciferase reporter assays and functional experiments. In vivo,… More >

ARMAND N. YAZDANI¹, MICHAELA PLETSCH¹, ABRAHAM CHORBAJIAN¹, DAVID ZITSER¹, VIKRANT RAI^1,2,*

BIOCELL, Vol.48, No.12, pp. 1683-1702, 2024, DOI:10.32604/biocell.2024.056252 - 30 December 2024

Abstract Mixed cholangiocarcinoma is a rare and aggressive neoplastic proliferation of biliary tract epithelial cells, accounting for up to 20% of primary liver cancers. It is the second most common primary liver malignancy with a 5-year survivability of less than 10% at diagnosis and is associated with various inflammatory diseases. Current management involves systemic chemotherapy, targeted radiation, and surgical resection, but long-term survival remains low, especially for surgically unresectable cases. Novel discoveries and understandings of the tumor microenvironment reveal new opportunities for targeted therapies for cholangiocarcinoma. Specifically, new pharmaceuticals including cell-based vaccines, tumor-associated neutrophils, and hepatic… More >

Sanxia Shi, Yinglei Song^*

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2911-2934, 2024, DOI:10.32604/cmc.2024.055363 - 18 November 2024

Abstract Infrared small target detection technology plays a pivotal role in critical military applications, including early warning systems and precision guidance for missiles and other defense mechanisms. Nevertheless, existing traditional methods face several significant challenges, including low background suppression ability, low detection rates, and high false alarm rates when identifying infrared small targets in complex environments. This paper proposes a novel infrared small target detection method based on a transformed Gaussian filter kernel and clustering approach. The method provides improved background suppression and detection accuracy compared to traditional techniques while maintaining simplicity and lower computational costs.… More >

Suya Li¹, Ying Cao^1,*, Hengyi Ren², Dongsheng Zhu³, Xin Xie¹

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 1449-1470, 2024, DOI:10.32604/cmc.2024.056824 - 15 October 2024

Abstract Multi-object tracking (MOT) has seen rapid improvements in recent years. However, frequent occlusion remains a significant challenge in MOT, as it can cause targets to become smaller or disappear entirely, resulting in low-quality targets, leading to trajectory interruptions and reduced tracking performance. Different from some existing methods, which discarded the low-quality targets or ignored low-quality target attributes. LQTTrack, with a low-quality association strategy (LQA), is proposed to pay more attention to low-quality targets. In the association scheme of LQTTrack, firstly, multi-scale feature fusion of FPN (MSFF-FPN) is utilized to enrich the feature information and assist… More >

Tongan Yu¹, Yali Xue^1,*, Yiming He¹, Shan Cui², Jun Hong²

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 1235-1250, 2024, DOI:10.32604/cmc.2024.056075 - 15 October 2024

Abstract With the rapid development of deep learning-based detection algorithms, deep learning is widely used in the field of infrared small target detection. However, well-designed adversarial samples can fool human visual perception, directly causing a serious decline in the detection quality of the recognition model. In this paper, an adversarial defense technology for small infrared targets is proposed to improve model robustness. The adversarial samples with strong migration can not only improve the generalization of defense technology, but also save the training cost. Therefore, this study adopts the concept of maximizing multidimensional feature distortion, applying noise… More >