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  • Open Access

    ARTICLE

    Real-Time Moving Targets Detection in Dynamic Scenes

    Fan Li1, Yang Yang

    CMES-Computer Modeling in Engineering & Sciences, Vol.107, No.2, pp. 103-124, 2015, DOI:10.3970/cmes.2015.107.103

    Abstract The shift of the camera leads to unsteadiness of backgrounds in video sequences. The motion of camera will results in mixture of backgrounds and foregrounds motion. So it is a challenge for targets detection in dynamic scenes. A realtime moving target detection algorithm with low complexity in dynamic scenes is proposed in this paper. Sub-block based image registration is applied to remove the global motion of the video frame. Considering the blocks in one frame have different motion vectors, the global motion of each block is separately estimated. Then, a neighbor-based background modeling is applied More >

  • Open Access

    ARTICLE

    Experimental and Numerical Study of Dynamic Fragmentation in Laser Shock-Loaded Gold and Aluminium Targets

    E. Lescoute1, T. De Rességuier1, J.-M. Chevalier2, J. Breil3, P.-H. Maire2, G. Schurtz3

    CMC-Computers, Materials & Continua, Vol.22, No.3, pp. 219-238, 2011, DOI:10.3970/cmc.2011.022.219

    Abstract With the ongoing development of high energy laser facilities designed to achieve inertial confinement fusion, the ability to simulate debris ejection from metallic shells subjected to intense laser irradiation has become a key issue. We present an experimental and numerical study of fragmentation processes generating high velocity ejecta from laser shock-loaded metallic targets (aluminium and gold). Optical transverse shadowgraphy is used to observe and analyze dynamic fragmentation and debris ejection. Experimental results are compared to computations involving a fragmentation model based on a probabilistic description of material tensile strength. A correct overall consistency is obtained. More >

  • Open Access

    ABSTRACT

    in silico Method for the Identification of Mycobacterial sp. Potential Drug Targets

    Ashutosh Singh1, Shruti Mishra2, Dhwani Raghav1, Asheesh shanker1, Vinay Sharma1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.6, No.2, pp. 119-124, 2008, DOI:10.3970/icces.2008.006.119

    Abstract Drug resistance has increased the pace of war against the ever-growing challenge of mycobacterial infections particularly with the growing menace of tuberculosis (TB).Previous studies reported several essential and virulent genes of mycobacterium like virS gene and mymA operon[1] through experimental approaches. However, Post genomic approach applied for the identification of targets for tuberculosis which includes the comparison of Mycobacterium tuberculosis CDC1551 proteome against database of essential genes and proteome of Homo sapiens. A total of approx 4000 proteins were studied and compared and 19 proteins were found to possess potentiality to call as Targets. More >

  • Open Access

    ARTICLE

    Cytokines as potential therapeutic targets for inflammatory skin diseases

    Robert P. Numerofa, Charles A. Dinarellob, Khusru Asadullahc

    European Cytokine Network, Vol.16, No.2, pp. 101-103, 2005

    Abstract A network of pro-inflammatory cytokines is a central feature in the pathophysiology of cutaneous inflammatory diseases. Thus, the delineation of precise roles for particular cytokines and the development of cytokine-directed therapeutics have become areas of intense investigation. While anti-TNF therapeutics have proven to be effective for the treatment of psoriasis, clinical investigations have now begun with other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development too. In this short review, we summarize key findings from a More >

  • Open Access

    ARTICLE

    Keratinocytes as targets for interleukin-10-related cytokines: a putative role in the pathogenesis of psoriasis

    Katia Boniface1, Jean-Claude Lecron1, François-Xavier Bernard2, Guy Dagregorio3, Gérard Guillet4, François Nau1, Franck Morel1

    European Cytokine Network, Vol.16, No.4, pp. 309-319, 2005

    Abstract Cytokines are key factors in the cross talk between the immune system and other systems including hepatic, nervous, cardiac and cutaneous systems, leading to an adaptive and integrated response of the organism to stress. They are also involved in the regulation of many processes, including hematopoiesis, the immune response and inflammation. IL-10 is one of the most important anti-inflammatory cytokines. Five cytokines structurally related to IL-10 have been described and presently form this family of cytokines: IL-19, IL-20, IL-22, IL-24 and IL-26. In contrast to IL-10, these cytokines display pro-inflammatory activities in different tissues, including More >

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