Jack Considine¹, Kyle O'Hollaren¹, Codrut Radoiu¹, Raghav Madan¹, Aron Liaw^1,2, Nivedita Dhar^2,3

Canadian Journal of Urology, Vol.31, No.3, pp. 11898-11903, 2024

Abstract Introduction: Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by chronic pelvic pain and usually accompanies lower urinary tract symptoms. We have previously reported that amniotic bladder therapy (ABT) provides symptomatic improvement in refractory IC/BPS patients for up to 3 months. Herein, we evaluated the durability of ABT up to 6 months.
Materials and methods: Consecutive IC/BPS patients received intra-detrusor injections of 100 mg micronized amniotic membrane. Clinical evaluation and patient reported outcome measurements including Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), Bladder Pain/ Interstitial Cystitis Symptom Score (BPIC-SS) and Overactive Bladder Assessment Tool (OAB)… More >

Evangelia Vlachou¹, Burles Avner Johnson 3rd^1,2, Elizabeth Guancial³, Kara A. Lombardo^1,2,4, Jean Hoffman-Censits^1,2

Canadian Journal of Urology, Vol.31, No.3, pp. 11875-11879, 2024

Abstract Introduction: Immune checkpoint inhibitors (ICIs) are approved for advanced urothelial cancer alone and as first line in combination with enfortumab vedotin. Platinum based chemotherapy which is another frontline choice is often not a treatment option for older patients due to comorbidities that increase with age. Despite ICIs being better tolerated compared to traditional chemotherapy little is known about their efficacy and toxicity in patients ≥ 90 years due to the rarity of this population in clinical trials. Our objective was to analyze the efficacy and toxicity of immune checkpoint inhibitors in patients ≥ 90 years.
Materials and… More >

Roseanne Ferreira¹, Emad Alwashmi^1,2, Samuel Otis-Chapados¹, Naeem Bhojani³, Kevin C. Zorn⁴, Bilal Chughtai⁵, Dean S. Elterman¹

Canadian Journal of Urology, Vol.31, No.4, pp. 11943-11949, 2024

Abstract Introduction: Despite the growing body of literature on sacral neuromodulation (SNM) outcomes, research focusing on male patients remains limited and often represented by small cohorts nested within a larger study of mostly women. Herein, we evaluated the outcomes of SNM in a male-only cohort with overactive bladder (OAB), fecal incontinence (FI), chronic bladder pain, and neurogenic lower urinary tract dysfunction (NLUTD).
Materials and methods: This retrospective cohort study included 64 male patients who underwent SNM insertion between 2013 and 2021 at a high-volume tertiary center. Indications for SNM therapy included OAB, FI, chronic pelvic pain, and NLUTD.… More >

Matthew Buell, Brian Hu

Canadian Journal of Urology, Vol.31, No.5, pp. 12026-12029, 2024

Abstract Radical cystectomy is a preferred treatment for muscle invasive bladder cancer. Despite known complications, rapid onset, severe hyperkalemia necessitating abortion of surgery has not been reported. In this case report, a patient with end stage renal disease (ESRD) undergoing attempted cystectomy developed severe intraoperative hyperkalemia and acidosis that led to abortion of surgery and transfer to the medical intensive care unit for emergent hemodialysis. The multifactorial etiology was related to respiratory acidosis, ESRD, patient positioning, clipping of ureters, and body habitus, as well as an idiopathic element. Knowledge of hyperkalemia etiologies can assist in diagnosis More >

Daniel Steffens^1,2,3, Cherry Koh^1,2,3,4, Nicholas Hirst^1,2, Ruby Cole^1,2, Michael J. Solomon^1,2,3,4, Lisa Nguyen-Lal⁵

Canadian Journal of Urology, Vol.31, No.5, pp. 12004-12012, 2024

Abstract Introduction: The evidence on the effectiveness of prehabilitation in patients undergoing bladder cancer surgery remains lacking. Thus, the aim of this study is to determine the effectiveness of prehabilitation on reducing postoperative morbidity and length of hospital stay in patients undergoing bladder cancer surgery.
Materials and methods: This systematic review included randomized controlled trials investigating the effect of prehabilitation on postoperative outcomes in patients undergoing bladder cancer surgery. A comprehensive search was conducted, with two reviewers independently screening articles and extracting data. The Cochrane Collaboration’s tool was used to assess risk of bias, and GRADE to rate… More >

Gabrielle R. Yankelevich¹, Kale Moreland², Makayla M. Swancutt², Robert L. Grubb¹

Canadian Journal of Urology, Vol.31, No.6, pp. 12035-12044, 2024

Abstract Introduction: We report the first scoping review of the clinical urologic literature for photodynamic therapy (PDT) among multiple urologic malignancies.
Materials and methods: A scoping review using Medline and Embase was performed for treatment of urologic malignancies with PDT.
Results: There were 84 papers included with the majority involving bladder and prostate cancer. Upper tract urothelial cancer (UTUC) only comprised three publications and there was no clinical data for renal or testicular cancer. Utilizing PDT in prostate cancer led to a negative biopsy rate of 30%-100%. Bladder cancer treatment with PDT had a 3-month complete response rate of More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.11, pp. 1819-1819, 2024, DOI:10.32604/or.2024.056893 - 16 October 2024

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.10, pp. 1693-1694, 2024, DOI:10.32604/or.2024.056909 - 18 September 2024

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.9, pp. 1537-1537, 2024, DOI:10.32604/or.2024.056125 - 23 August 2024

Abstract This article has no abstract. More >

He Li¹, Xianchao Liu^2,*, Jidong Li¹, Yuchen Qiu²

Energy Engineering, Vol.121, No.8, pp. 2293-2311, 2024, DOI:10.32604/ee.2024.048752 - 19 July 2024

Abstract When employing stepwise inertial control (SIC), wind power generation can offer significant frequency support to the power system, concurrently mitigating energy shortages and suppressing secondary frequency drop. Nonetheless, further investigation is imperative for implementing stepped inertia control due to variations in frequency regulation capabilities and operational safety among diverse wind farm groups. Consequently, this paper advocates a multi-wind farm ladder timing SIC method designed to alleviate secondary drops in system frequency. Initially, the paper introduces the fundamental principles of stepped inertia control for a doubly-fed induction generator (DFIG) and deduces the relationship between support energy,… More >