Alexander Agranovich¹, Piotr Czaykowski², David Hui³, Tom Pickles⁴, Winkle Kwan¹

Canadian Journal of Urology, Vol.10, No.6, pp. 2056-2061, 2003

Abstract Objective: To review retrospectively the outcome and toxicity of Radiotherapy (RT) in the cohort of elderly patients (EP) with muscle-invasive urinary bladder carcinoma (MIUBC).
Methods: Thirty-six EP were treated with RT with radical intent. The age of the cohort ranged from 71 to 89 years with a median of 79 years. Eighty percent of the patients had Eastern Cooperative Oncology Group (ECOG) 0 and 1 performance status. Conventional and accelerated fractionation RT regimen were utilized.
Results: With median follow up of 45.8 months, the median survival was 23.9 months. There was a trend toward better survival in patients More >

Sanoj P. Punnen, Joseph L. Chin, Michael A. S. Jewett

Canadian Journal of Urology, Vol.10, No.2, pp. 1790-1795, 2003

Abstract Introduction and objective: BCG is the most efficacious intravesical treatment for superficial bladder cancer. However, 30%-40% of tumors are refractory. BCG failure is an indication for cystectomy but several salvage intravesical (IVe) strategies have been proposed. Early results with reduced dose BCG in combination with IFN-α in patients are currently the most promising. We have adopted this approach and now report our preliminary results. This is the first report of this salvage therapy from Canada, the birthplace of IVe BCG therapy for superficial bladder cancer.
Methods: The “O’Donnell protocol” of reduced dose IVe BCG plus IFN-α was… More >

Daniel D. Cohen, Claudine Lamarre, Louis Lamarre, Fred Saad

Canadian Journal of Urology, Vol.9, No.6, pp. 1694-1697, 2002

Abstract The first recorded case of lymphoma of the bladder was reported by Eve and Chaffey in 1885.1 Malignant lymphoma of the bladder can be classified into one of three different clinical groups: 1) Primary lymphoma localized to the bladder; 2) Lymphoma presenting in the bladder as the first sign of disseminated disease (non-localized lymphoma); 3) Recurrent bladder involvement by lymphoma in patients with a history of malignant lymphoma (secondary lymphoma). Primary extranodal marginal zone lymphoma of mucosa associated lymphoid tissue (MALT type) of the urinary bladder, first described by Kempton et al in 1990, is More >

Roanne Segal¹, Eric Winquist², Himu Lukka³, Joseph L. Chin⁴, Michael Brundage⁵, B. R. Markman⁶

Canadian Journal of Urology, Vol.9, No.5, pp. 1625-1633, 2002

Abstract Background and purpose: To examine the role of adjuvant chemotherapy in the treatment of patients with deep muscle-invasive transitional cell carcinoma (TCC) of the bladder who have undergone cystectomy.
Materials and methods: A systematic review of the published literature was combined with a consensus process, involving the interpretation of evidence within the context of conventional practice, to develop an evidence-based practice guideline for use in Ontario.
Results: Five randomized controlled trials (RCTs) comparing adjuvant chemotherapy with observation were found that reported data on survival. Sample sizes of the trials were small, and each of the trials evaluated a cisplatin-based… More >

Waleed Ali Hasan, Reem Al-Bareeq, Moh'd Durazi, Shaker Al-Muttawa

Canadian Journal of Urology, Vol.9, No.3, pp. 1565-1567, 2002

Abstract Herein we report a rare combination of two urological tumors simultaneously: renal cell carcinoma of the kidney and transitional cell carcinoma of the bladder. A 67 year old male presented with hematuria. He was diagnosed with left renal cell carcinoma and transitional cell carcinoma of the bladder. Subsequently this patient underwent left nephrectomy (palliative) to control the pain and transurethral resection of bladder tumor. The clinical picture, radiographic and histological finding are presented, as well as the treatment offered. More >

Yves Fradet

Canadian Journal of Urology, Vol.9, No.3, pp. 1544-1550, 2002

Abstract Superficial bladder tumors are by far the most common form of bladder cancer managed by practicing urologists. Indeed up to 75% of initial tumors fall in this category and because of the high recurrence rate, superficial tumors represent over 90% of tumor events being treated. New diagnostic methods have been developed to improve the sensitivity of tumor detection of both cystoscopy and urinary cytology. Risk stratification of patients based on simple clinical parameters provides new opportunities for adapting monitoring strategies as well as providing a rationale for the use of intravesical chemotherapy and immunotherapy. Finally, More >

Vincent G. Bird¹, Howard N. Winfield²

Canadian Journal of Urology, Vol.9, No.2, pp. 1500-1502, 2002

Abstract There are reports of a wide variety of foreign materials, placed purposefully or inadvertantly, that have been found in the lower urinary tract. Due to encrustatation, some of these objects may initially appear to be simple stones. A careful evaluation with an appropriate index of suspicion is needed to aid in the determination of whether one of these complex structures may be present. A determination of the composition of the structure will allow the surgeon to employ the most safe and expeditious means of removal. We report a case of a large bladder stone with More >