K. Kuramoto¹, M. Furuichi², K. Kakuda²

CMES-Computer Modeling in Engineering & Sciences, Vol.106, No.3, pp. 169-186, 2015, DOI:10.3970/cmes.2015.106.169

Abstract This paper describes a scheme to improve efficiency of multi-agent simulation system (MAS) on single computer that has multiple processor cores. Simulation technology is applied for broad usage in the world, and MAS gathers attention from the fields that treat complicated and non-numeric issues such as traffic analysis, analyzing evacuation from a building, and defense training. Since the requirements of simulation scale and fidelity are growing, the importance of their performance is also increasing. However, CPU clock speedup is slowing, and improvement of computer performance has come to depend on the number of processors, cores,… More >

Leonard G. Gomella¹, Daniel P. Petrylak², Bobby Shayegan³

Canadian Journal of Urology, Vol.21, Suppl.2, pp. 1-6, 2014

Abstract instruction: Introduction: Newer approaches to the management of advanced prostate cancer have rapidly evolved. While basic androgen deprivation remains as the first line in newly diagnosed hormone naïve metastatic prostate cancer, the agents used and strategies followed have undergone significant changes. Numerous new agents such as sipuleucel-T, abiraterone, enzalutamide, cabazitaxel and radium-223 have all been approved since 2010 to treat metastatic castration-resistant prostate cancer (CRPC). New imaging techniques to detect advanced disease such as F-18 PET, 11C-choline PET and other modalities are becoming available. The concepts of "bone health" and the management of side effects related… More >

V. K. Srivastava¹, A. Pizzi^2,3,*

Journal of Renewable Materials, Vol.2, No.3, pp. 201-206, 2014, DOI:10.7569/JRM.2014.634107

Abstract Fine wood powder/furanic foams were prepared with a strong predominance of the wood component. Low weight and density are important properties of foamed composites. Focusing on preparing light materials, wood foam composites were made using a chemical foaming method and expanded using diethyl ether as the foaming agent. The additives were added to note their effect on the density and mechanical properties, like impact strength and Young’s moduli, of the expanded composites. Various tests and scanning electron microscopy analysis were also performed. The foaming agent resulted in closed cells with varied sizes and more or More >

F. S. Tabatabaei^∗, M. Jazayeri^†, P. Ghahari^‡, N. Haghighipour^§

Molecular & Cellular Biomechanics, Vol.11, No.3, pp. 209-220, 2014, DOI:10.3970/mcb.2014.011.209

Abstract During orthodontic treatments, applied mechanical forces create strain and result in tooth movement through the alveolar bone. This response to mechanical strain is a fundamental biological reaction. The present study evaluated the effect of equiaxial strain within the range of orthodontic forces on the osteogenic differentiation of human dental pulp stem cells (hDPSCs). Following isolation and culture of hDPSCs, 3rd passage cells were transferred on a silicone membrane covered with collagen. Cell adhesion to the membrane was evaluated under scanning electron microscope (SEM). Cells were divided into three groups: the first group was placed in… More >

Hideki Fujii¹, Shinobu Yoshimura¹

CMES-Computer Modeling in Engineering & Sciences, Vol.88, No.1, pp. 49-64, 2012, DOI:10.3970/cmes.2012.088.049

Abstract Recently, global warming issues have been discussed all over the world. Of the total amount of CO₂ emitted in Japan, a transportation sector is responsible for 20%. In the transportation sector, 90% of the emission is due to road traffic. This amount must be reduced drastically to realize a low-carbon society. To do so, various measures have been discussed, and the effects of the measures must be estimated quantitatively. In conventional measurement methods, the amount of vehicle emission is simply calculated by multiplying travel distance or gasoline consumption by a specified emission coefficient. Such an approach… More >

William A. Easton

Canadian Journal of Urology, Vol.17, Suppl.1, pp. 12-17, 2010

Abstract The symptoms of overactive bladder (OAB) -- urinary urgency, frequency, and urge incontinence -- can cause signifi cant lifestyle limitations. Social isolation, depression, employment diffi culties, and relationship stress are common fi ndings in patients with this condition. This article focuses on women with OAB who are seen in primary care. Occasionally, OAB (or detrusor overactivity) may be the result of neurological disease, metabolic disease, or urinary tract abnormalities. Primary care practitioners can play a key role in identifying affected individuals by including a focused question in every annual patient physical assessment. Investigation and treatment More >

Richard Casey¹, Zsuzsanna Gesztesi¹, Joseph Rochford²

Canadian Journal of Urology, Vol.17, No.3, pp. 5170-5177, 2010

Abstract Objectives: To evaluate the effect of zoledronic acid on androgen deprivation therapy in patients with hormone-sensitive prostate cancer by measuring the percentage change in lumbar-spine bone mineral density (BMD) at 12 and 24 months.
Materials and methods: An open-label, multicenter, randomized, two-phase study was conducted in patients with hormone-sensitive prostate cancer (N = 200) receiving 10.8 mg goserelin acetate with or without zoledronic acid (4 mg intravenously) every 3 months. In phase I, patients were randomized to goserelin acetate alone or goserelin acetate plus zoledronic acid for 12 months. In phase II, patients receiving goserelin acetate plus… More >

Hideki Fujii¹, Shinobu Yoshimura¹, Kazuya Seki¹

CMES-Computer Modeling in Engineering & Sciences, Vol.63, No.3, pp. 265-282, 2010, DOI:10.3970/cmes.2010.063.265

Abstract Traffic system is a typical complex system emerged through interactions among a large number of traffic actors such as car drivers, pedestrians and others. We model each actor as an intelligent agent that can judge and act by itself autonomously, and develop a traffic simulator named MATES, which is based on an intelligent multi-agent model. In this simulator, microscopic behaviors of the traffic actors cause macroscopic traffic phenomena through their interaction. In this research, we newly develop a coordinative behavior model among multiple cars, and implement it to MATES to enhance the reproducibility of traffic More >

Calin Popa^1,2, Pilar Barrera², Leo A. B. Joosten^1,2,3, Piet L. C. M. van Riel², Bart-Jan Kullberg^1,3, Jos W. M. van der Meer^1,3, Mihai G. Netea^1,3

European Cytokine Network, Vol.20, No.2, pp. 88-83, 2009, DOI:10.1684/ecn.2009.0150

Abstract Infectious complications are not rare in rheumatoid arthritis (RA), and the susceptibility to infec-tions is increased during treatment with TNF blocking agents. As a possible mechanism contributing to that, we assessed the modulation of cytokine production induced by TNF neutralization. Methods. Whole blood cultures from six healthy volunteers and 13 RA patients starting therapy with either adalimumab (n = 7) or etanercept (n = 6) were stimulated with heat-killed Salmonella typhimurium, Staphylococcus aureus or with S. typhimurium lipopolysaccharide (LPS). The production of interleukin (IL)-1β, IL-6, IL10, IL-17, TNF, IL-8 and IFN-γ was measured by specific immunoassays. Results. Stimulation … More >

Massimiliano Mirolo^1,*, Marco Fabbri^1,*, Marina Sironi^1,*, Annunciata Vecchi², Angelo Guglielmotti³, Giorgina Mangano³, Giuseppe Biondi³, Massimo Locati^1,4, Alberto Mantovani^1,4

European Cytokine Network, Vol.19, No.3, pp. 119-122, 2008, DOI:10.1684/ecn.2008.0133

Abstract Bindarit is an indazolic derivative that is devoid of any immunosuppressive effects and has no effect on arachidonic acid metabolism. However, it has been proved to have anti-inflammatory activity in a number of experimental diseases, including pancreatitis, arthritis, and lupus nephritis. This therapeutic effect has been associated with its ability to interfere selectively with monocyte recruitment, although the underlying molecular mechanisms are unknown. Here we comprehensively examine the effect of bindarit on the chemokine system, and report that in activated monocytes and endothelial cells, it selectively inhibits the production of the monocyte chemotactic protein subfamily More >