Hyun-Jung Moon,1 So-Young Park,1 Su-Hoon Lee, Chi-Dug Kang, Sun-Hee Kim

Oncology Research, Vol.27, No.7, pp. 835-847, 2019, DOI:10.3727/096504019X15517850319579

Abstract Recently, novel therapeutic strategies have been designed with the aim of killing cancer stem-like cells (CSCs), and considerable interest has been generated in the development of specific therapies that target stemnessrelated marker of CSCs. In this study, nonsteroidal anti-inflammatory drugs (NSAIDs) significantly potentiated Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG)-mediated cytotoxicity through apoptotic and autophagic cell death induction, but COX-2-inhibitory function was not required for NSAIDinduced autophagy in CD44-overexpressing human chronic myeloid leukemia K562 (CD44^highK562) cells. Importantly, we found that treatment with NSAIDs resulted in a dose-dependent increase in LC3-II level and decrease in p62 level and simultaneous reduction… More >

Yan Gao¹, Chunli Wang¹, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 93-93, 2019, DOI:10.32604/mcb.2019.07322

Abstract At present, anterior cruciate ligament (ACL) damage repair is still a huge challenge. Our previous studies indicated that the Lysyl oxidase (LOX) were significantly reduced in injurious ACL fibroblasts, which is the major reason for its poor healing ability. The main purpose of our study was to detected the potential of LOX to act as an anabolic agent in injured ACL. The effect of LOX on the ACL at a concentration of 20ng/mL was investigated. The molecular mechanisms and signaling pathway were elucidated by RNA-sequencing, q-PCR and western blotting. For the in vivo study, the… More >

Romero-Castillo PA¹, MC Pérez Amador Barron¹, P Guevara Fefer¹, V Muñoz Ocotero¹, A Reyes Dorantes², F Aguirre Garcia², A Amaya Chavez³

Phyton-International Journal of Experimental Botany, Vol.82, pp. 75-80, 2013, DOI:10.32604/phyton.2013.82.075

Abstract The search for new anti-inflammatory drugs with fewer side effects than those currently available in the market has recently attracted the interest of scientists. Medicinal plants might be a natural source of medicines. Such is the case with Ziziphus amole (Sessé & Moc.) M.C. Johnst. or corongoro, a plant species native to México. It is used in traditional medicine as an anti-inflammatory drug, a healing substance and an analgesic, and in the treatment of diarrhea, diabetes, asthma and hemorrhoids. The aim of this study was to evaluate the anti-inflammatory effect of Z. amole in the acute 12-O-tetradecanoylphorbol-13-acetate… More >

Pérez-Amador¹ MC, V Muñoz Ocotero¹, S Pérez Benitez¹, F García Jiménez²

Phyton-International Journal of Experimental Botany, Vol.77, pp. 275-282, 2008, DOI:10.32604/phyton.2008.77.275

Abstract The presence of phototoxic compounds in stems and leaves of young plants of Vernonia patens Kunth was confirmed by TLC. These compounds were in smaller amounts in younger than in adult plants of this species. Only the stems presented specific activity of these compounds from the two study plant organs. It included characteristic UV bands at 200 and 300nm, and phototoxic activity against Bacillus subtilis (ATCC-6633). Stems and leaves of Vernonia patens also showed anti-inflammatory activity and bactericide potential. More >