Patrizia Alessi¹, Daria Leali¹, Maura Camozzi¹, AnnaRita Cantelmo², Adriana Albini², Marco Presta¹

European Cytokine Network, Vol.20, No.4, pp. 225-234, 2009, DOI:10.1684/ecn.2009.0175

Abstract Angiogenesis, the formation of new blood vessels from the endothelium of the existing vasculature, plays a pivotal role in tumor growth, progression and metastasis. Over the last 30 years, numerous pro- and antiangiogenic molecules, their ligands, and intracellular signaling pathways have been identified, and signifi-cant efforts have been undertaken to develop antiangiogenic strategies for cancer therapy. Agents that selec-tively target vascular endothelial growth factor (VEGF) and its receptors have shown promising activity in clin-ical trials and have been approved for use in selected cancer indications. However, patients may ultimately develop resistance to these drugs. One… More >

Kenji Tsuruta¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.13, No.3, pp. 63-64, 2009, DOI:10.3970/icces.2009.013.063

Abstract Unique properties in artificially designed new materials are demonstrated via multiple-scale computational techniques. A density-functional/classical molecular-dynamics method is employed to investigate segregation dynamics of dopants in nanostructured ceramics/semiconductors. We also develop a classical electromagnetic simulation algorithm combining with an electronic-structure calculation for analysis on optical properties of meta-materials. We demonstrate that these novel algorithms are highly optimized for ultra-scale parallel computers. More >

Tak-Sing Wong^*, Branden Brough^†, Chih-Ming Ho^∗,‡

Molecular & Cellular Biomechanics, Vol.6, No.1, pp. 1-56, 2009, DOI:10.3970/mcb.2009.006.001

Abstract Mimicking nature's approach in creating devices with similar functional complexity is one of the ultimate goals of scientists and engineers. The remarkable elegance of these naturally evolved structures originates from bottom-up self-assembly processes. The seamless integration of top-down fabrication and bottom-up synthesis is the challenge for achieving intricate artificial systems. In this paper, technologies necessary for guided bottom-up assembly such as molecular manipulation, molecular binding, and the self assembling of molecules will be reviewed. In addition, the current progress of synthesizing mechanical devices through top-down and bottom-up approaches will be discussed. More >

Atsuya Oishi¹, Shinobu Yoshimura²

CMES-Computer Modeling in Engineering & Sciences, Vol.28, No.2, pp. 127-146, 2008, DOI:10.3970/cmes.2008.028.127

Abstract This paper describes new methods based on genetic approaches for finding approximating expressions of local coordinates of a contact point in a local contact search process. A contact search process generally consists of the following two phases: a global search phase for finding the nearest node-segment pair and a local search phase for finding an exact local coordinate of the contact point within the segment. The local contact search can be regarded as the mapping from the coordinates of nodes to the local coordinates of contact points. In this paper, two methods are proposed to… More >

Chih-Ping Wu^1,2, Kuan-Hao Chiu², Yung-Ming Wang²

CMC-Computers, Materials & Continua, Vol.8, No.2, pp. 93-132, 2008, DOI:10.3970/cmc.2008.008.093

Abstract The article is to present an overview of various three-dimensional (3D) analytical approaches for the analysis of multilayered and functionally graded (FG) piezoelectric plates and shells. The reported 3D approaches in the literature are classified as four different approaches, namely, Pagano's classical approach, the state space approach, the series expansion approach and the asymptotic approach. Both the mixed formulation and displacement-based formulation for the 3D analysis of multilayered piezoelectric plates are derived. The analytical process, based on the 3D formulations, for the aforementioned approaches is briefly interpreted. The present formulations of multilayered piezoelectric plates can… More >

Ronald S. Boris, Sanjeev A. Kaul, Richard C. Sarle, Hans J. Stricker

Canadian Journal of Urology, Vol.14, No.3, pp. 3566-3570, 2007

Abstract Objective: To compare perioperative, functional and oncological outcomes of a single surgeon's experience with retropubic (RRP), perineal (RPP), and robotic assisted (RARP) radical prostatectomy.
Methods: Results from 150 radical prostatectomies performed by a single surgeon were compared. The groups consisted of the last 50 consecutive RRP (group 1) and RPP patients (group 2) and his first 50 RARP patients (group 3). He had significant experience in RRP and RPP and extensive training prior to performing RARP. The data was obtained from record review and patient survey. Patient demographics, operative parameters, pathological characteristics, complications, and functional outcomes… More >

Frédéric Gibou¹, Chohong Min², Hector D. Ceniceros³

FDMP-Fluid Dynamics & Materials Processing, Vol.3, No.1, pp. 37-48, 2007, DOI:10.3970/fdmp.2007.003.037

Abstract We describe two finite difference schemes for simulating incompressible flows on nonuniform meshes using quadtree/octree data structures. The first one uses a cell-centered Poisson solver that yields first-order accurate solutions, while producing symmetric linear systems. The second uses a node-based Poisson solver that produces second-order accurate solutions and second-order accurate gradients, while producing nonsymmetric linear systems as the basis for a second-order accurate Navier-Stokes solver. The grids considered can be non-graded, i.e. the difference of level between two adjacent cells can be arbitrary. In both cases semi-Lagrangian methods are used to update the intermediate fluid More >

R. S. Tuan¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 229-230, 2006, DOI:10.32604/mcb.2006.003.229

Abstract This article has no abstract. More >

A. Frangi¹, L. Ghezzi, P. Faure-Ragani²

CMES-Computer Modeling in Engineering & Sciences, Vol.15, No.1, pp. 41-48, 2006, DOI:10.3970/cmes.2006.015.041

Abstract Three dimensional magneto-mechanical problems at low frequency are addressed by means of a coupled fast Boundary Element - Finite Element approach with total scalar potential and focusing especially on the issue of global force calculation on movable ferromagnetic parts. The differentiation of co-energy in this framework and the use of Maxwell tensor are critically discussed and the intrinsic links are put in evidence. Three examples of academic and industrial applications are employed for validation. More >

Z. D. Han¹, H. T. Liu¹, A. M. Rajendran², S. N. Atluri³

CMES-Computer Modeling in Engineering & Sciences, Vol.14, No.2, pp. 119-128, 2006, DOI:10.3970/cmes.2006.014.119

Abstract This paper presents the implementation of a three-dimensional dynamic code, for contact, impact, and penetration mechanics, based on the Meshless Local Petrov-Galerkin (MLPG) approach. In the current implementation, both velocities and velocity-gradients are interpolated independently, and their compatibility is enforced only at nodal points. As a result, the time consuming differentiations of the shape functions at all integration points is avoided, and therefore, the numerical process becomes more stable and efficient. The ability of the MLPG code for solving high-speed contact, impact and penetration problems with large deformations and rotations is demonstrated through several computational More >