Xiang Rao^1,2,*, Yina Liu^1,2

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.3, pp. 1403-1429, 2022, DOI:10.32604/cmes.2022.018879 - 19 April 2022

Abstract Projection-based embedded discrete fracture model (pEDFM) is an effective numerical model to handle the flow in fractured reservoirs, with high efficiency and strong generalization of flow models. However, this paper points out that pEDFM fails to handle flow barriers in most cases, and identifies the physical projection configuration of fractures is a key step in pEDFM. This paper presents and proves the equivalence theorem, which explains the geometric nature of physical projection configurations of fractures, that is, the projection configuration of a fracture being physical is equivalent to it being topologically homeomorphic to the fracture, More >

Guanni Qu^1,#, Tianai Yue^2,#,*, Xiaoyu Zhang³, Shibiao Wei³

FDMP-Fluid Dynamics & Materials Processing, Vol.18, No.3, pp. 591-608, 2022, DOI:10.32604/fdmp.2022.017776 - 22 February 2022

Abstract The present study stems from the realization that the general problem relating to the analysis of wind-induced vibrations in suspension bridges still requires significant attention. Sidewalk railings, overhaul tracks, and deflectors are known to largely affect such dynamics. Here, the influence of a row of water-filled traffic barriers on the response of a sample suspension bridge is investigated numerically. It is shown that the existence of water barriers causes flow separation and non-negligible vortices with respect to the condition with no water barriers. The vortex shedding frequency at the far end is around 41.30 Hz, More >

Sherif S. M. Ghoneim^1,*, Mosleh M. Alharthi¹, Ragab A. El-Sehiemy², Abdullah M. Shaheen³

Intelligent Automation & Soft Computing, Vol.31, No.3, pp. 1593-1610, 2022, DOI:10.32604/iasc.2022.020464 - 09 October 2021

Abstract A new procedure to optimally identifying the prediction equation of oil breakdown voltage with the barrier parameters’ effect is presented. The specified equation is built based on the results of experimental works to link the response with the barrier parameters as the inputs for hemisphere-hemisphere electrode gap configuration under AC voltage. The AC HV is applied using HV Transformer Type (PGK HB-100 kV AC) to the high voltage electrode in the presence of a barrier immersed in Diala B insulating oil. The problem is formulated as a nonlinear optimization problem to minimize the error between… More >

KAI WANG^2,#, FENGTIAN ZHANG^1,3,4,#, CHANGLONG WEN⁵, ZHIHUA HUANG⁶, ZHIHAO HU¹, YUWEN ZHANG¹, FUQIANG HU^2,*, LIJUAN WEN^1,6,*

Oncology Research, Vol.29, No.5, pp. 351-363, 2021, DOI:10.32604/or.2022.025696 - 10 October 2022

Abstract The blood-brain barrier (BBB) is an essential component in regulating and maintaining the homeostatic microenvironment of the central nervous system (CNS). During the occurrence and development of glioblastoma (GBM), BBB is pathologically destroyed with a marked increase in permeability. Due to the obstruction of the BBB, current strategies for GBM therapeutics still obtain a meager success rate and may lead to systemic toxicity. Moreover, chemotherapy could promote pathological BBB functional restoration, which results in significantly reduced intracerebral transport of therapeutic agents during multiple administrations of GBM and the eventual failure of GBM chemotherapy. The effective More >

HUI ZHANG^1,3,#, SHIRUI CHEN^1,3,#, MENGTING LIU^1,2, YAOCHI WANG^1,2, CONG XIN^1,2, JING MA^1,3, XIAODONG ZHENG^1,2, YUANDI HUANG^1,2, BO ZHANG^3,4, XUEJUN ZHANG^1,2, LIANGDAN SUN^1,2,*, SEN YANG^1,3,*

BIOCELL, Vol.45, No.5, pp. 1321-1335, 2021, DOI:10.32604/biocell.2021.016524 - 12 July 2021

Abstract The skin is the largest organ of the human body, and its aging is visible to the naked eye. The aging rate of men and women is slightly different. This study compared the protein expression of skin samples on the curved forearms of 11 healthy women and 9 healthy men. Quantitative proteomics analysis found that the expression of epidermal proteins in men and women of the same age group was different. Compared with female skin, in male skin, 20 proteins were upregulated, and 7 proteins were downregulated. These data suggest that men and women have… More >

JINGRONG SONG^#, JUAN KANG^#, WEI LV, YAN DONG, XIAOYING ZHANG^*

BIOCELL, Vol.45, No.3, pp. 723-731, 2021, DOI:10.32604/biocell.2021.014453 - 03 March 2021

Abstract Bronchial asthma is a common chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), inflammatory cell infiltration, and airway remodeling. F-box/WD repeat-containing protein 7 (FBXW7), an E3 ubiquitin ligase, is required for various endothelial functions, such as cell migration, inflammation, and endothelial integrity. This study aimed to investigate the role of FBXW7 in lipopolysaccharide (LPS)-induced epithelial barrier impairment in bronchial epithelial cells in vitro. By using lentivirus-based technology, FBXW7 was overexpressed or silenced (24 h) in human bronchial epithelial (16HBE) cells, which were treated with LPS or not (24 h). Immunoprecipitation (IP) detection and Western blot… More >

Zishen Li¹, Xiangling Gao^{1, *}, Zicheng Tang²

CMES-Computer Modeling in Engineering & Sciences, Vol.123, No.3, pp. 1105-1129, 2020, DOI:10.32604/cmes.2020.09047 - 28 May 2020

Abstract The numerical simulation for a new type of precast concrete barrier for viaducts is carried out systematically. To obtain an accurate representation of the damage state of the concrete barrier under the impact of a vehicle, a stochastic damage-plasticity model of the concrete is adopted in the finite element model. Meanwhile, a simplified mathematical model of the impact between vehicles and the concrete barrier was established and the input energy was converted to the impact load to facilitate the investigation of the safety performance of the concrete barriers. On this basis, a refined finite element More >

D. O. Redchyts¹, E. A. Shkvar^2,*, S. V. Moiseienko³

FDMP-Fluid Dynamics & Materials Processing, Vol.15, No.5, pp. 509-525, 2019, DOI:10.32604/fdmp.2019.08266

Abstract A mathematical model for unsteady electro- and aerodynamic processes in the presence of a plasma actuator has been elaborated through physical modeling of the dielectric barrier discharge. A specialized computational fluid dynamics package has been developed accordingly in order to calculate steady and unsteady laminar and turbulent flows. For the numerical simulation of the dielectric barrier discharge, in particular, two equations have been added to the Navier-Stokes equations and solved. They describe the distribution of the applied voltage and the charged particles density. The impact of the plasma actuator on air has been accounted for… More >

Erik B. Kistler¹, Geert W. Schmid-Schönbein^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 8-8, 2019, DOI:10.32604/mcb.2019.07256

Abstract A longstanding question in research on organ failure after physiological shock (such as trauma, burns, sepsis, surgery and medical emergencies) is the underlying mechanism for a progressive loss of cell and tissue functions. Our systematic analysis of this problem has served to identify digestive enzymes as key players [1, 2]. After synthesis and discharge from the pancreas, the digestive enzymes are usually contained inside the lumen of the small intestine where they break down food every day. Escape of the digestive enzymes out of the lumen of the intestine is kept to a minimum by… More >

Jianing Zhang^1,2, Ziying Yu¹, Hengxu Yang^1,2, Ming Wu¹, Jun Yang^1,2,*

Sound & Vibration, Vol.53, No.2, pp. 2-15, 2019, DOI:10.32604/sv.2019.03783

Abstract Ultrasound can be used as a carrier to realize wireless communication to and from a metal-enclosed space, which has the characteristics such as immunity to the electromagnetic shielding effect and non-destructive penetration of metal obstacles. This paper firstly reviews the previous studies in the field of ultrasonic wireless communication through metal barriers, and summarizes their achievements and the existing problems. Secondly, an overview of the research methods involved in studying the characteristic of acoustic-electric channel is presented, and the principles are introduced for the actual measurement method, equivalent circuit method, ABCD parameter method, finite element More >