Sait Can Yucebas^*

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 49-71, 2023, DOI:10.32604/iasc.2023.036871

Abstract The number of studies in the literature that diagnose cancer with machine learning using genome data is quite limited. These studies focus on the prediction performance, and the extraction of genomic factors that cause disease is often overlooked. However, finding underlying genetic causes is very important in terms of early diagnosis, development of diagnostic kits, preventive medicine, etc. The motivation of our study was to diagnose bladder cancer (BCa) based on genetic data and to reveal underlying genetic factors by using machine-learning models. In addition, conducting hyper-parameter optimization to get the best performance from different models, which is overlooked in… More >

GUSTAVO MARTÍN VILLOLDO¹, MARÍA TERESA POMBO², MARIANA ARIS³, JOAQUÍN CHEMI¹, PABLO MANDÓ³, SUPRIYA NAGARAJU⁴, JUAN CAMEAN¹, ADRIÁN BURIONI¹, DEBORAH EGEA¹, MORA AMAT⁵, JOSÉ LEÓN MELLADO³, JOSÉ MORDOH³, ALBERTO VILLARONGA¹, MARÍA MARCELA BARRIO^3,*

Oncology Research, Vol.31, No.2, pp. 207-220, 2023, DOI:10.32604/or.2023.028163

Abstract Intravesical Bacillus Calmette Guerin (BCG) is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer (NMIBC). However, the response rate is ~60%, and 50% of non-responders will progress to muscle-invasive disease. BCG induces massive local infiltration of inflammatory cells (Th1) and ultimately cytotoxic tumor elimination. We searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte (TIL) polarization in the tumor microenvironment (TME) in pre-treatment biopsies. Pre-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG (n = 32) were evaluated retrospectively by immunohistochemistry. TME polarization was assessed by quantifying the T-Bet+ (Th1) and GATA-3+… More > Graphic Abstract

Chaoying Liu^1,#, Xinfeng Yang^2,#, Ye Wang^2,#, Keyu Wu², Siqiang Li², Gailing Wang², Yun Li², Chuanfeng Li², Mingcheng Wang², Enzhong Li^2,*

Oncologie, Vol.24, No.4, pp. 679-691, 2022, DOI:10.32604/oncologie.2022.025705

Abstract A cell is the basic unit of life, and death is inevitable for any cell. However, cancer cells that deviate from the normal track can resist death and survive. Ferroptosis is recently discovered as a modulated cell death different from other known forms of cell death in morphology, biochemistry, and genetics. It is characterized by iron-dependent lipid peroxidation regulated by various metabolic pathways. The incidence and mortality of genitourinary system cancer have been increasing recently. Although clinical practice therapy techniques have improved, no plan with a positive prognosis has been identified. For the therapy of cancer, ferroptosis opens up new… More >

Weifeng Ren^1,2,#, Xiaomeng Cai^2,3,#, Jun Chen^2,3,#, Lifo Ruan^2,3, Huiru Lu², Jiayu Zhang^2,3, Yi Hu^2,3,*, Jimin Gao^1,*

Oncologie, Vol.23, No.3, pp. 359-371, 2021, DOI:10.32604/Oncologie.2021.018605

Abstract This study reported the construction of GM-CSF-loaded chitosan/graphene oxide nanoparticles for photothermal therapy-assisted immunotherapy against murine orthotopic bladder cancer. The encapsulated GM-CSF in chitosan/graphene oxide nanoparticles facilitated their immobilization on biotinylated mouse orthotopic bladder cancer surface, resulting in slow release of antitumor immune adjuvant. Locally released GM-CSF efficiently recruited dendritic cells to bladder tumor sites, thereby promoting immune responses in mice. Thus, the activated immune response in mice provided enhanced antitumor effects. Meanwhile, the thermal effect from the nanoparticles upon light irradiation induced a significant increase in dendritic cells and T cells compared with other groups, which confirmed that the… More >