Daniel J. Sadowski¹, Chandy S. Ellimoottil², Ajay Tejwani³, Alex Gorbonos¹

Canadian Journal of Urology, Vol.20, No.6, pp. 7015-7020, 2013

Abstract Introduction: Proton therapy (PT) for prostate cancer is an expensive treatment with limited evidence of benefit over conventional radiotherapy. We sought to study whether online information on PT for prostate cancer was balanced and whether the website source influenced the content presented.
Materials and methods: We applied a systematic search process to identify 270 weblinks associated with PT for prostate cancer, categorized the websites by source, and filtered the results to 50 websites using predetermined criteria. We then used a customized version of the DISCERN instrument, a validated tool for assessing the quality of consumer health information,… More >

Jesse D. Sammon^1,2,*, Bartosz F. Kaczmarek^1,2,*, Praful Ravi¹, Maxine Sun³, Florian Roghmann³, Shyam Sukumar^1,2, Khurshid Ghani^1,2, Pranav Sharma^1,2, Pierre I. Karakiewicz³, James O. Peabody¹, Jack S. Elder¹, Mani Menon¹, Quoc-Dien Trinh^1,2,4

Canadian Journal of Urology, Vol.20, No.6, pp. 7008-7014, 2013

Abstract Introduction: Though the prevalence of metastatic prostate cancer is decreasing, the rate of admission from the emergency department (ED) is increasing. Little is known about the implications of metastatic site on a patient's ED course and admission.
Materials and methods: A weighted estimate of 15,367 patients with metastatic prostate cancer who presented to the ED between January 1, 2006 and December 31, 2009 was abstracted from the United States Nationwide Emergency Department Sample (NEDS). Descriptive statistics were used to elaborate patient and hospital characteristics of the metastatic prostate cancer population and logistic regression models were fitted to… More >

Hüseyin Engin¹, Yücel Üstündağ², ˙Ishak Özel Tekin³, Ayla Gökmen⁴

European Cytokine Network, Vol.23, No.1, pp. 21-24, 2012, DOI:10.1684/ecn.2012.0301

Abstract Background/Aim: Ang-1 and Ang-2 have both been identified as ligands for Tie-2, a receptor expressed on endothelial cells (EC). They play critical roles in angiogenesis, in concert with VEGF. Ang-1-binding to Tie-2 maintains and stabilizes mature vessels by promoting interactions between EC and the surrounding extra-cellular matrix. However, Ang-2 shows context-dependent, proangiogenic and antiangiogenic activities. Despite the rapidly accumulating histopathological data reporting differences in the expression of members of the Ang family on the surface of various normal and tumour cells, data for these growth factors in plasma from cancer patients, including gastric cancer, remain… More >

Hüseyin Engin¹, Yücel Üstündağ², İshak Özel Tekin³, Ayla Gökmen⁴, Şehmuz Ertop⁴, Sevil Uygun İlikhan⁵

European Cytokine Network, Vol.23, No.2, pp. 68-71, 2012, DOI:10.1684/ecn.2012.0308

Abstract Background/Aim: despite the rapidly accumulating histopathological data reporting differences in the expression of members of the angiopoietin family on the surface of various normal and tumour cells, data for these growth factors in plasma from cancer patients, including colon cancer, are scarce. The aims of the present study were to measure the plasma concentrations of Ang-1, Ang-2 and Tie-2 in colon cancer patients, and to assess the correlation between the concentrations of these factors and the stage of the tumor. Patients and methods: the study cohort included 36 patients (18 male, 18 female) with colon… More >

Mahboobeh Razmkhah¹, Mansoureh Jaberipour¹, Akbar Safaei², Abdol-Rasoul Talei³, Nasrollah Erfani¹, Abbass Ghaderi^1,4

European Cytokine Network, Vol.23, No.3, pp. 72-77, 2012, DOI:10.1684/ecn.2012.0310

Abstract Background: Lymph nodes (LNs) are among the first sites of tumor metastasis. The expression of chemokines and chemokine receptors in LNs are involved in cancer prognosis and are considered to be good predictors of tumor progression. The main aim of this study was to assess the expression of important, tumorpromoting chemokines and chemokine receptors in LNs of breast cancer patients. Methods: LNs were isolated from eighteen women diagnosed with breast cancer. Data were compared between positive and negative LNs. Expression of chemokines and chemokine receptors were determined by quantitative real-time PCR (qRT-PCR) and flow cytometry.… More >

Sabeer Rehsia, Bobby Shayegan

Canadian Journal of Urology, Vol.19, Suppl.5, pp. 28-35, 2012

Abstract Prostate cancer remains a common cancer diagnosis and cause of cancer-related death in men. Despite it’s high prevalence, screening for prostate cancer for early detection remains controversial. This article outlines evidence from contemporary prostate cancer screening clinical trials and presents an overview of therapeutic options across the spectrum of prostate-cancer states. More >

Leonard G. Gomella

Canadian Journal of Urology, Vol.19, No.1, pp. 6069-6069, 2012

Abstract This article has no abstract. More >

J. Ryan Mark, Francisco Gelpi-Hammerschmidt, Edouard J. Trabulsi, Leonard G. Gomella

Canadian Journal of Urology, Vol.19, No.2, pp. 6227-6231, 2012

Abstract In patients with non-muscle invasive bladder cancer, fluorescence cystoscopy can improve the detection and ablation of bladder tumors. In this paper we describe the technique and practical aspects of hexaminolevulinate (HAL) fluorescence cystoscopy, also known as “blue light cystoscopy”. More >

Daniel J. Canter, Kenneth Ogan, Viraj A. Master

Canadian Journal of Urology, Vol.19, No.2, pp. 6211-6216, 2012

Abstract The current treatment standard of care for patients who present de novo or with a recurrent bladder tumor is transurethral resection of the bladder tumor (TURBT) using monopolar or bipolar electrocautery in the form of a 90-degree loop electrode, which has been used since its introduction in 1952. This intervention, accomplished transurethrally, is both diagnostic and potentially therapeutic for patients with bladder cancer, especially for low grade, non muscle-invasive bladder tumors. Although usually safe and sufficient, this technique can create technical challenges, especially in the dynamically changing spherical space of the bladder. Bipolar energy has… More >

Yves Collin¹, Anne Méziat-Burdin², Robert Sabbagh³

Canadian Journal of Urology, Vol.19, No.2, pp. 6204-6206, 2012

Abstract Laparoscopic indications are still growing due to the acquisition and development of new skills and expertise in the laparoscopic field. We report the first case of a successful transperitoneal right radical nephrectomy after intraperitoneal hyperthermic chemotherapy in a 56-year-old female who previously underwent multiple abdominal surgeries for appendicular adenocarcinoma with pseudomyxoma peritonei. In patients with multiples previous abdominal surgeries and intraperitoneal chemotherapy, transperitoneal laparoscopic surgeries are feasible in experienced hands. However, patient safety is paramount and conversion to open surgery should always be considered in case of complications. More >