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  • Open Access


    Awareness of Human Papilloma Virus and Its Association with Cervical Cancer among Female University Students: A Study from United Arab Emirates

    Madhumitha Kedhari Sundaram1, Abdulmajeed G. Almutary2, Shafiul Haque3, Faheem SM1, Arif Hussain1,*

    Oncologie, Vol.23, No.2, pp. 269-277, 2021, DOI:10.32604/Oncologie.2021.016002

    Abstract Cervical cancer is the neoplasm of the uterine cervix in women, which is highly preventable. With the advent of vaccination against HPV infection, a gradual decline in the incidence of cervical cancer cases has been observed in developing countries. The developing nations bear the brunt of cervical cancer incidence due to low acceptance of vaccination. This survey-based study was designed to assess the awareness and opinions of female university students regarding human papilloma virus, vaccination and cervical cancer. A survey questionnaire was distributed among female expatriate students (18 to 26 years of age) of a… More >

  • Open Access


    Growth and Invasion of 3D Spheroid Tumor of HeLa and CasKi Cervical Cancer Cells

    Kalaivani Muniandy1, Zuhaida Asra Ahmad1,4, Sylvia Annabel Dass1, Shaharum Shamsuddin2, Nethia Mohana Kumaran3, Venugopal Balakrishnan1,*

    Oncologie, Vol.23, No.2, pp. 279-291, 2021, DOI:10.32604/Oncologie.2021.015969

    Abstract Spheroids are generally self-assembled cells with the ability to generate their extracellular matrix, including the complex cell-matrix and the cell-cell interactions that resemble the functional characteristics of the corresponding tissue in vivo. The study aimed to develop a three-dimensional (3D) spheroid system for the cervical cancer cell lines, HeLa (HPV18), CaSki (HPV16), SiHa (HPV16), C33A (non-HPV), HT3 (non-HPV) as well as to identify its biological activity in the extracellular form. For the formation of the cervical cancer spheroids, the liquid overlay approach was applied, followed by embedding to the bovine collagen I matrix. Spheroid formation using More >

  • Open Access


    Nucleus Detection on Pap Smear Images for Cervical Cancer Diagnosis: A Review Analysis

    Afiqah Halim1, Wan Azani Mustafa1,2,*, Wan Khairunizam Wan Ahmad1, Hasliza A. Rahim2, Hamzah Sakeran3

    Oncologie, Vol.23, No.1, pp. 73-88, 2021, DOI:10.32604/Oncologie.2021.015154

    Abstract Cervical cancer is a cell disease in the cervix that develops out of control in the female body. The cervix links the vagina (birth canal) with the upper section of the uterus, which can only be found in the female body. This is the second leading cause of death among women around the world. However, cervical cancer is currently one of the most preventable cancers if early detection is identified. The effect of unidentified cancer may increase the risk of death when the cell disease spreads to other parts of the female anatomy (metastasize). The… More >

  • Open Access


    Cervical Diseases Prediction Using LHVR Techniques

    Praveena Rajasekaran*, Preetha Jaganathan, Anjali Annadurai

    Computer Systems Science and Engineering, Vol.36, No.3, pp. 477-484, 2021, DOI:10.32604/csse.2021.014247

    Abstract The stabilizing mechanisms of cervical spine spondylosis are involved in the degenerating segmentation vertebra, which often causes pain. Health of the individual is affected, both physically and mentally. Due to depression, nervousness, and psychological damages occur thereby losing their human activity functions. The nucleus pulposus of spinal disc herniation is prolapsed through a deficiency of annulus fibrosus. A jelly-like core part of the disc contains proteins that cause the tissues to become swollen when it touches the nucleus pulposus. The proposed Gradient Linear Classification (GLC) algorithm is used for the efficient automatic classification of disc More >

  • Open Access


    Microenvironment and related genes predict outcomes of patients with cervical cancer: evidence from TCGA and bioinformatic analysis


    BIOCELL, Vol.44, No.4, pp. 597-605, 2020, DOI:10.32604/biocell.2020.011328

    Abstract Cervical cancer (CESC) is one of the most common cancers and affects the female genital tract. Consistent HPV infection status has been determined to be a vital cause of tumorigenesis. HPV infection may induce changes to the immune system and limit the host’s immune response. Immunotherapy is therefore essential to improving the overall survival of both locally advanced and recurrent CESC patients. Using 304 relevant samples from TCGA, we assessed immune cell function in CESC patients to better understand the status of both tumor micro-environment cells and immune cells in CESC. Functional enrichment analysis, pathway… More >

  • Open Access


    A Narrative Review: Classification of Pap Smear Cell Image for Cervical Cancer Diagnosis

    Wan Azani Mustafa1,*, Afiqah Halim1, Khairul Shakir Ab Rahman2

    Oncologie, Vol.22, No.2, pp. 53-63, 2020, DOI:10.32604/oncologie.2020.013660

    Abstract Cervical cancer develops as cells transformation in the cervix of a female that connects the uterus to the vagina. This cancer may impact the columnal epithelial cells of the cervix and therefore can be expanded to the lymphatic and circulatory system (metastasize), sometimes the kidneys, liver, prostate, vagina, and rectum. Many of the cervical cancer patients survived by taking early prevention by undergoing a Pap Smear Test. However, the result of the test usually takes a few weeks which is extremely time-consuming especially at the government hospital. The purpose of this research was to study… More >

  • Open Access


    TNFα increases in vitro migration of human HPV18-positive SW756 cervical carcinoma cells


    BIOCELL, Vol.29, No.3, pp. 303-311, 2005, DOI:10.32604/biocell.2005.29.303

    Abstract TNFα has been associated with both, tumor survival and apoptosis. This cytokine is also involved in promoting cell migration during wound healing and tumorigenesis. SW756 is a HPV18-positive cervical carcinoma cell line, which has been used to study different mechanisms of cervical cancer progression. An in vitro assay of scratch wound healing onto monolayers of SW756 cells was used to assess the effect of TNFα on cell migration into a wound space. It was found that SW756 cells have the ability to migrate, but not proliferate in response to scratch wounding in a serum-free medium supplemented More >

  • Open Access


    Review : Uterine mast cells: A new hypothesis to understand how we are born


    BIOCELL, Vol.28, No.1, pp. 1-11, 2004, DOI:10.32604/biocell.2004.28.001

    Abstract Birth is the result of complex, well-defined, and coordinated events, that are tightly regulated by endocrine, nervous, and immune responses, and take place primarily in the female reproductive tract. Various mechanisms and mediators involved in pregnancy, labor, and delivery, are highly conserved among different mammalian species and mast cells emerge as potential and crucial participants in these processes, as it is discussed in this review. More >

  • Open Access


    Overexpression of inhibin α (1-32) fusion protein promotes apoptosis and cell cycle arrest in a cervical cancer cell model (Hela cells)

    Yanhong ZHEN1, Li HAN2, Kailai CAI1, Lijun HUO1, Hasan RIAZ1, Canjie WU1, Aixin LIANG1 , Lei SANG1, Liguo YANG1 *

    BIOCELL, Vol.38, No.1, pp. 17-24, 2014, DOI:10.32604/biocell.2014.38.017

    Abstract Inhibins play important roles in the reproductive system. To evaluate whether inhibin α (1-32) fusion protein plays a role in cervical cancer growth, the plasmid pVAX-inhα was constructed and its effect on proliferation and apoptosis of the human cervical cancer cell line (Hela) was checked by flow cytometry and real-time PCR. The expression and localization of inhibin α protein were detected by RT-PCR and confocal microscopy which showed that inhibin α protein was expressed and localized in the nucleus of Hela cells. Over expression of inhibin α gene significantly induced cell apoptosis and ceased S… More >

  • Open Access


    LncRNA LINC01772 promotes metastasis and EMT process in cervical cancer by sponging miR-3611 to relieve ZEB1

    Tong MA1, §, Fafen WANG2, §, Xiaohui WANG1

    BIOCELL, Vol.43, No.3, pp. 191-198, 2019, DOI:10.32604/biocell.2019.06989

    Abstract Cervical cancer (CC), has been identified as one of the most frequent malignant tumors all over the world, with high mortality in females. A growing number of investigations have confirmed that long noncoding RNAs (lncRNAs) play a crucial role in the progression of multiple cancers. Nonetheless, the biological function and regulatory mechanism of LINC01772 in CC haven’t been explored so far. In this study, LINC01772 expression was found to be upregulated in tissues and cells of CC. Knocking down LINC01772 suppressed CC cell proliferation, migration and epithelial-mesenchymal transition (EMT) process. Through molecular mechanism assays,… More >

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