PARISA SHIRI AGHBASH^1,2,4, NIMA HEMMAT¹, BEHZAD BARADARAN^1,3, AHAD MOKHTARZADEH¹, VAHDAT POORTAHMASEBI^2,4, MAHIN AHANGAR OSKUEE^2,4, HOSSEIN BANNAZADEH BAGHI^1,2,4,*

Oncology Research, Vol.30, No.3, pp. 99-116, 2022, DOI:10.32604/or.2022.026776

Abstract Infection with high-risk human papillomavirus (HPV), including HPV-16 and HPV-18, is the main cause of malignancies, such as cervical cancer. Viral oncoproteins encoded by HPV are expressed in HPV-positive cancers and associated with the early cancer stages and the transformation of normal cells. The signaling pathways involved in the transformation of normal cells to cancerous form and the subsequently expressed programmed cell death-ligand 1 (PD-L1) on the surface of the transformed cells lead to a disruption in recognition of tumor cells by the immune cell system, including T lymphocytes and dendritic cells which lead to the development of cervical cancer… More > Graphic Abstract

Chaoying Liu^1,#, Xinfeng Yang^2,#, Ye Wang^2,#, Keyu Wu², Siqiang Li², Gailing Wang², Yun Li², Chuanfeng Li², Mingcheng Wang², Enzhong Li^2,*

Oncologie, Vol.24, No.4, pp. 679-691, 2022, DOI:10.32604/oncologie.2022.025705

Abstract A cell is the basic unit of life, and death is inevitable for any cell. However, cancer cells that deviate from the normal track can resist death and survive. Ferroptosis is recently discovered as a modulated cell death different from other known forms of cell death in morphology, biochemistry, and genetics. It is characterized by iron-dependent lipid peroxidation regulated by various metabolic pathways. The incidence and mortality of genitourinary system cancer have been increasing recently. Although clinical practice therapy techniques have improved, no plan with a positive prognosis has been identified. For the therapy of cancer, ferroptosis opens up new… More >

Md Zahid Hasan Ontor¹, Md Mamun Ali¹, Kawsar Ahmed^2,3,*, Francis M. Bui³, Fahad Ahmed Al-Zahrani⁴, S. M. Hasan Mahmud⁵, Sami Azam⁶

CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 3727-3741, 2023, DOI:10.32604/cmc.2023.032794

Abstract Cervical Cancer (CC) is a rapidly growing disease among women throughout the world, especially in developed and developing countries. For this many women have died. Fortunately, it is curable if it can be diagnosed and detected at an early stage and taken proper treatment. But the high cost, awareness, highly equipped diagnosis environment, and availability of screening tests is a major barrier to participating in screening or clinical test diagnoses to detect CC at an early stage. To solve this issue, the study focuses on building a deep learning-based automated system to diagnose CC in the early stage using cervix… More >

NUR AIN ALIAS¹, WAN AZANI MUSTAFA^1,2,*, MOHD AMINUDIN JAMLOS³, AHMED ALKHAYYAT⁴, KHAIRUL SHAKIR AB RAHMAN⁵, RAMI Q. MALIK⁶

Oncology Research, Vol.29, No.5, pp. 365-376, 2021, DOI:10.32604/or.2022.025897

Abstract Cervical cancer is a prevalent and deadly cancer that affects women all over the world. It affects about 0.5 million women anually and results in over 0.3 million fatalities. Diagnosis of this cancer was previously done manually, which could result in false positives or negatives. The researchers are still contemplating how to detect cervical cancer automatically and how to evaluate Pap smear images. Hence, this paper has reviewed several detection methods from the previous researches that has been done before. This paper reviews pre-processing, detection method framework for nucleus detection, and analysis performance of the method selected. There are four… More >

Yao Wu^1,2,#, Bin Qu^1,#, Haoming Shen¹, Hongyu Deng¹, Faqin Tang^1,*

Oncologie, Vol.24, No.3, pp. 499-512, 2022, DOI:10.32604/oncologie.2022.024951

Abstract Background: Tumor-specific growth factor (TSGF) is associated with invasion and metastasis of various malignancies and adverse clinical outcomes. TSGF is also highly expressed in cervical cancer (CC), but its clinical value is unclear. Materials and Methods: Serum samples from malignancies, including CC, non-Hodgkin’s lymphoma (NHL), nasopharyngeal carcinoma (NPC), colorectal cancer (CRC), lung cancer (LCA), ovarian cancer (OC), breast cancer (BC), gastric carcinoma (GC), and pancreatic cancer (PC) were collected, and TSGF was detected using a chemiluminescence assay. The patients with CC were followed-up over five years, and their clinicopathological parameters were analyzed. Meanwhile, the pre- and post-treatment TSGF levels of… More >

S. Priya^1,*, N. K. Karthikeyan¹, D. Palanikkumar²

Intelligent Automation & Soft Computing, Vol.35, No.3, pp. 2673-2685, 2023, DOI:10.32604/iasc.2023.028599

Abstract In recent years, cervical cancer is one of the most common diseases which occur in any woman regardless of any age. This is the deadliest disease since there were no symptoms shown till it is diagnosed to be the last stage. For women at a certain age, it is better to have a proper screening for cervical cancer. In most underdeveloped nations, it is very difficult to have frequent scanning for cervical cancer. Data Mining and machine learning methodologies help widely in finding the important causes for cervical cancer. The proposed work describes a multi-class classification approach is implemented for… More >

NIMA HEMMAT¹, MOHAMMAD AMIN DOUSTVANDI¹, ZAHRA ASADZADEH¹, AHAD MOKHTARZADEH¹, BEHZAD BARADARAN^1,4,*, HOSSEIN BANNAZADEH BAGHI^1,2,3,*

Oncology Research, Vol.29, No.2, pp. 141-148, 2021, DOI:10.32604/or.2022.023346

Abstract Cervical cancer is a growing global disease in developing countries. Persistent infection with human papillomaviruses (HPV) is an essential causative agent in this type of cancer. Several studies demonstrate HPV E5 oncoprotein can impress the normal life cycle of HPV-infected cells by targeting some pivotal cellular signaling pathways, such as the epidermal growth factor receptor (EGFR) signaling pathway. In this study, we used E5-siRNA to knockdown that essential oncogene and considered the effect of E5 silencing on proliferation, apoptosis, cell cycle, apoptosis-related gene expression, and the initiator of the EGFR signaling pathway in cervical cancer cells. The results demonstrate that… More >

Cong Ye^*, Yubo Hu^†, Junrong Wang^*

Oncology Research, Vol.27, No.2, pp. 183-192, 2019, DOI:10.3727/096504018X15201124340860

Abstract A large number of microRNAs (miRNAs) are aberrantly expressed in cervical cancer and play crucial roles in the onset and progression of cervical cancer by acting as either an oncogene or a tumor suppressor. Therefore, investigation of the expression, biological roles, and underlying mechanisms of miRNAs in cervical cancer might provide valuable therapeutic targets in the treatment for patients with this disease. In this study, miRNA- 377 (miR-377) was downregulated in cervical cancer tissues and cell lines. Decreased miR-377 expression was strongly correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, and distant metastasis in… More >

Juan Li^*†1, Chunyan Liu^‡1, Dawei Li^§, Meng Wan^¶, Hong Zhang^†, Xiaoxia Zheng^†, Xuemei Jie^†, Pengju Zhang^¶, Jingjing Li^#, Hongchun Hou^†, Qing Sun^*

Oncology Research, Vol.27, No.7, pp. 763-771, 2019, DOI:10.3727/096504018X15399955297355

Abstract OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover that OLFM4 expression is significantly reduced in metastatic cervical cancer. Accordingly, overexpression of OLFM4 inhibits epithelial–mesenchymal transition (EMT), migration, and invasion in human cervical cancer cells. To further explore its molecular mechanisms, we reveal that OLFM4 augmentation interferes with mTOR signaling pathway, and the suppressive effects of OLFM4 on cell migration and invasion are largely weakened by phosphatidic acid (PA)-induced mTOR signal activation, which implicates the… More >

Dan Shan, Yumin Shang, Tongxiu Hu

Oncology Research, Vol.27, No.3, pp. 349-358, 2019, DOI:10.3727/096504018X15247361080118

Abstract Cervical cancer is the third most common gynecological cancer and the fourth leading cause of cancer-related deaths in women around the world. Substantial evidence has demonstrated that microRNA (miRNA) expression is disordered in many malignant tumors. The dysregulation of miRNAs has been suggested to be involved in the tumorigenesis and tumor development of cervical cancer. Therefore, identification of miRNAs and their biological roles and targets involved in tumor pathology would provide valuable insight into the diagnosis and treatment of patients with cervical cancer. MicroRNA-411 (miR-411) has been reported to play an important role in several types of human cancer. However,… More >