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  • Open Access

    ARTICLE

    Ultra-conservative noncoding RNA uc.243 confers chemo-resistance by facilitating the efflux of the chemotherapeutic drug in ovarian cancer

    SHAN JIANG1,2, XIUFENG LIN2, YANFEI CHEN3, XINNING LI3, JIALI KANG1,4,*

    BIOCELL, Vol.48, No.8, pp. 1265-1273, 2024, DOI:10.32604/biocell.2024.051478 - 02 August 2024

    Abstract Background: Despite improvements in objective response rates to cisplatin-based combination chemotherapy, the majority of advanced ovarian cancer remains suboptimal, resulting in poor survival. it has been found that non-coding RNAs (ncRNAs) not only participate in the transmission of signals between various cells but also participate in tumor immunity and anti-tumor immune responses, thereby regulating tumor occurrence and development. However, the function and detailed mechanism of ultraconserved RNA (ucRNA) in ovarian cancer chemoresistance is still unclear. Methods: Western blotting assay, Quantitative real-time PCR analysis (qPCR), and Kaplan-Meier Plotter analysis were performed to analyze the expression and prognosis… More >

  • Open Access

    ARTICLE

    Cu Stress-Induced Transcriptome Alterations in Sorghum and Expression Analysis of the Transcription Factor-Encoding Gene SbWRKY24

    Mingchuan Yang1, Jia Zheng2, Wenhui Yu1, Yanghua Li2, Yali Wang1, Zilu Zhang1, Zhenhui Kang1,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.7, pp. 1503-1521, 2024, DOI:10.32604/phyton.2024.051718 - 30 July 2024

    Abstract Sorghum is not only an important bio-energy crop but also a vital raw material for brewing. Exogenous copper affects the growth and metabolism of crops in specific ways. This study identified 8475 differentially expressed genes (DEGs) by high-throughput transcriptome sequencing in the sorghum cultivar ‘Jinnuoliang 2’ after 24 h of treatment with 10 mM CuSO. Using GO analysis, 476 genes were functionally annotated, which were mainly related to catabolism and biosynthetic processes. Additionally, 90 pathways were annotated by employing the KEGG analysis. Among them, glutathione metabolism and peroxisome were induced, while photosynthesis, photosynthesis-antenna protein, and… More >

  • Open Access

    RETRACTION

    Retraction: Long Noncoding RNA XIST Regulates miR-137-EZH2 Axis to Promote Tumor Metastasis in Colorectal Cancer

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.8, pp. 1385-1385, 2024, DOI:10.32604/or.2024.055037 - 17 July 2024

    Abstract This article has no abstract. More >

  • Open Access

    RETRACTION

    Retraction: Knockdown of Long Noncoding RNA CAT104 Inhibits the Proliferation, Migration, and Invasion of Human Osteosarcoma Cells by Regulating MicroRNA-381

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.8, pp. 1383-1383, 2024, DOI:10.32604/or.2024.055036 - 17 July 2024

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

    XIAOBI HUANG1,#, CHUNYUAN CHEN2, YONGYANG CHEN1,#, HONGLIAN ZHOU1, YONGHUA CHEN1, ZHONG HUANG1, YULIU XIE1, BAIYANG LIU1, YUDONG GUO1, ZHIXIONG YANG1, GUANGHUA CHEN3,*, WENMEI SU1,4,*

    Oncology Research, Vol.32, No.7, pp. 1185-1195, 2024, DOI:10.32604/or.2023.030771 - 20 June 2024

    Abstract Background: Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as oncogenes. Their dysregulation has been closely associated with tumorigenesis. LINC00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this cancer. However, the mechanism underlying its function in cancer progression remains poorly understood. Methods: Here, the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines, clinical samples, and xenografts. Results: We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients, whereas knockdown of LINC00265 inhibited proliferation… More >

  • Open Access

    ARTICLE

    A Dual Domain Robust Reversible Watermarking Algorithm for Frame Grouping Videos Using Scene Smoothness

    Yucheng Liang1,2,*, Ke Niu1,2,*, Yingnan Zhang1,2, Yifei Meng1,2

    CMC-Computers, Materials & Continua, Vol.79, No.3, pp. 5143-5174, 2024, DOI:10.32604/cmc.2024.051364 - 20 June 2024

    Abstract The proposed robust reversible watermarking algorithm addresses the compatibility challenges between robustness and reversibility in existing video watermarking techniques by leveraging scene smoothness for frame grouping videos. Grounded in the H.264 video coding standard, the algorithm first employs traditional robust watermark stitching technology to embed watermark information in the low-frequency coefficient domain of the U channel. Subsequently, it utilizes histogram migration techniques in the high-frequency coefficient domain of the U channel to embed auxiliary information, enabling successful watermark extraction and lossless recovery of the original video content. Experimental results demonstrate the algorithm’s strong imperceptibility, with… More >

  • Open Access

    REVIEW

    Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

    BINGJIE LI1,#, WENBO CAO1,2,3,#, JINJING XIAO1, YIXIAO CHEN1, QIYING WEI1, MINGJIN YUE4, SAIJUN MO1,2,3,*

    BIOCELL, Vol.48, No.6, pp. 923-934, 2024, DOI:10.32604/biocell.2024.049160 - 10 June 2024

    Abstract Perineural invasion (PNI), a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread, has the capacity to extend well beyond the primary tumor site, infiltrating distant regions devoid of lymphatic or vascular structures. PNI often heralds a decrease in patient survival rates and is recognized as an indicator of an unfavorable prognosis across a variety of cancers. Despite its clinical significance, the underlying molecular mechanisms of PNI remain elusive, complicating the development of specific and efficacious diagnostic and therapeutic strategies. In the realm of cancer research, non-coding RNAs (ncRNAs) have attracted considerable… More >

  • Open Access

    ARTICLE

    Infrared and Visible Image Fusion Based on Res2Net-Transformer Automatic Encoding and Decoding

    Chunming Wu1, Wukai Liu2,*, Xin Ma3

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1441-1461, 2024, DOI:10.32604/cmc.2024.048136 - 25 April 2024

    Abstract A novel image fusion network framework with an autonomous encoder and decoder is suggested to increase the visual impression of fused images by improving the quality of infrared and visible light picture fusion. The network comprises an encoder module, fusion layer, decoder module, and edge improvement module. The encoder module utilizes an enhanced Inception module for shallow feature extraction, then combines Res2Net and Transformer to achieve deep-level co-extraction of local and global features from the original picture. An edge enhancement module (EEM) is created to extract significant edge features. A modal maximum difference fusion strategy More >

  • Open Access

    ARTICLE

    Landscape of Sequence Variations in Homologous Copies of FAD2 and FAD3 in Rapeseed (Brassica napus L.) Germplasm with High/Low Linolenic Acid Trait

    Haoxue Wu#, Xiaohan Zhang§,#, Xiaoyu Chen, Kang Li, Aixia Xu, Zhen Huang, Jungang Dong, Chengyu Yu*

    Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 627-640, 2024, DOI:10.32604/phyton.2024.050321 - 28 March 2024

    Abstract Genetic manipulation (either restraint or enhancement) of the biosynthesis pathway of α-linolenic acid (ALA) in seed oil is an important goal in Brassica napus breeding. B. napus is a tetraploid plant whose genome often harbors four and six homologous copies, respectively, of the two fatty acid desaturases FAD2 and FAD3, which control the last two steps of ALA biosynthesis during seed oil accumulation. In this study, we compared their promoters, coding sequences, and expression levels in three high-ALA inbred lines 2006L, R8Q10, and YH25005, a low-ALA line A28, a low-ALA/high-oleic-acid accession SW, and the wildtype ZS11. The expression… More >

  • Open Access

    ARTICLE

    Intrusion Detection Model Using Chaotic MAP for Network Coding Enabled Mobile Small Cells

    Chanumolu Kiran Kumar, Nandhakumar Ramachandran*

    CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3151-3176, 2024, DOI:10.32604/cmc.2023.043534 - 26 March 2024

    Abstract Wireless Network security management is difficult because of the ever-increasing number of wireless network malfunctions, vulnerabilities, and assaults. Complex security systems, such as Intrusion Detection Systems (IDS), are essential due to the limitations of simpler security measures, such as cryptography and firewalls. Due to their compact nature and low energy reserves, wireless networks present a significant challenge for security procedures. The features of small cells can cause threats to the network. Network Coding (NC) enabled small cells are vulnerable to various types of attacks. Avoiding attacks and performing secure “peer” to “peer” data transmission is… More >

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