VINOTHKUMAR VEERASAMY¹, VEERAVARMAL VEERAN², SIDDAVARAM NAGINI^1,3,*

Oncology Research, Vol.33, No.8, pp. 1835-1860, 2025, DOI:10.32604/or.2025.064010 - 18 July 2025

Abstract The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway is one of the most frequently dysregulated signaling networks in oral squamous cell carcinoma (OSCC). Although the tumor microenvironment (TME) and epigenetic modifiers are recognized to play a pivotal role in aberrant activation of the PI3K/AKT pathway in OSCC, the available evidence is fragmentary and a comprehensive analysis is warranted. This review evaluates the intricate mechanisms by which various components of the TME facilitate proliferation, apoptosis evasion, invasion, migration, angiogenesis, metastasis, as well as therapy resistance in OSCC through activation of PI3K/AKT signalling. The review has also More >

Lingyun Xiang^*, Xu He, Xi Zhang, Chengfu Ou

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 2375-2389, 2025, DOI:10.32604/cmc.2025.065804 - 03 July 2025

Abstract Linguistic steganography (LS) aims to embed secret information into normal natural text for covert communication. It includes modification-based (MLS) and generation-based (GLS) methods. MLS often relies on limited manual rules, resulting in low embedding capacity, while GLS achieves higher embedding capacity through automatic text generation but typically ignores extraction efficiency. To address this, we propose a sentence attribute encoding-based MLS method that enhances extraction efficiency while maintaining strong performance. The proposed method designs a lightweight semantic attribute analyzer to encode sentence attributes for embedding secret information. When the attribute values of the cover sentence differ… More >

Yifeng Lin^1,2,#, Yuer Yang^1,2,3,#, Jianxiang Xie⁴, Tong Ji⁵, Peiya Li^2,*

CMC-Computers, Materials & Continua, Vol.84, No.2, pp. 2865-2882, 2025, DOI:10.32604/cmc.2025.065362 - 03 July 2025

Abstract Semantic secure communication is an emerging field that combines the principles of source-channel coding with the need for secure data transmission. It is of great significance in modern communications to protect the confidentiality and privacy of sensitive information and prevent information leaks and malicious attacks. This paper presents a novel approach to semantic secure communication through the utilization of joint source-channel coding, which is based on the design of an automated joint source-channel coding algorithm and an encryption and decryption algorithm based on semantic security. The traditional and state-of-the-art joint source-channel coding algorithms are selected More >

Yuan-Yu Tsai^1,*, Alfrindo Lin¹, Wen-Ting Jao¹, Yi-Hui Chen^2,*

CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 681-697, 2025, DOI:10.32604/cmc.2025.064370 - 09 June 2025

Abstract With the rapid expansion of multimedia data, protecting digital information has become increasingly critical. Reversible data hiding offers an effective solution by allowing sensitive information to be embedded in multimedia files while enabling full recovery of the original data after extraction. Audio, as a vital medium in communication, entertainment, and information sharing, demands the same level of security as images. However, embedding data in encrypted audio poses unique challenges due to the trade-offs between security, data integrity, and embedding capacity. This paper presents a novel interpolation-based reversible data hiding algorithm for encrypted audio that achieves… More >

Anand Deva Durai Chelladurai¹, Theena Jemima Jebaseeli², Omar Alqahtani¹, Prasanalakshmi Balaji^1,*, Jeniffer John Simon Christopher³

CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 1101-1122, 2025, DOI:10.32604/cmc.2025.062278 - 09 June 2025

Abstract Optical Coherence Tomography (OCT) provides cross-sectional and three-dimensional reconstructions of the target tissue, allowing precise imaging and quantitative analysis of individual retinal layers. These images, based on optical inhomogeneities, reveal intricate cellular structures and are vital for tasks like retinal segmentation. The proposed study uses OCT images to identify significant differences in peripapillary retinal nerve fiber layer thickness. Incorporating spectral-domain analysis of OCT images significantly enhances the evaluation of Purtcher Retinopathy. To streamline this process, the study introduces a Context Encoding Deep Neural Network (CEDNN), which eliminates the time-consuming manual segmentation process while improving the… More >

Chiara Innocente^1,*, Matteo Boemio², Gianmarco Lorenzetti², Ilaria Pulito², Diego Romagnoli², Valeria Saponaro², Giorgia Marullo¹, Luca Ulrich¹, Enrico Vezzetti¹

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.2, pp. 1355-1379, 2025, DOI:10.32604/cmes.2025.063186 - 30 May 2025

Abstract Lip-reading technology, based on visual speech decoding and automatic speech recognition, offers a promising solution to overcoming communication barriers, particularly for individuals with temporary or permanent speech impairments. However, most Visual Speech Recognition (VSR) research has primarily focused on the English language and general-purpose applications, limiting its practical applicability in medical and rehabilitative settings. This study introduces the first Deep Learning (DL) based lip-reading system for the Italian language designed to assist individuals with vocal cord pathologies in daily interactions, facilitating communication for patients recovering from vocal cord surgeries, whether temporarily or permanently impaired. To… More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.6, pp. 1509-1509, 2025, DOI:10.32604/or.2024.062048 - 29 May 2025

Abstract This article has no abstract. More >

YU HONG^1,#, YUNXIANG TANG^1,#, WENYAN ZHOU¹, HANYUE LUO², LINLIN BU², HUI QIU^3,*, QIUJI WU^3,*

Oncology Research, Vol.33, No.6, pp. 1347-1361, 2025, DOI:10.32604/or.2025.059327 - 29 May 2025

Abstract As a rising immune checkpoint on tumor cells, CD24 is closely related to tumorigenesis and progression. CD24 can directly regulate the malignant behavior of tumor cells and indirectly inhibit the function of immune cells in the meantime, which promotes the immune escape of tumor cells, induces cancer invasion and causes poor prognosis. The basic principle of cancer treatment is to induce cell death and inhibit cell survival. Resistance to chemoradiotherapy is a critical challenge in oncology, which limits the effectiveness of anti-cancer treatments. Many studies have shown a strong association between CD24 and chemoradiotherapy More >

LIBO LIANG¹, XINYI WANG^2,3,4, YUPING ZENG^2,3,4, HAO CHEN^2,3,4, WEN ZHOU¹, HONGYING MU^2,3,4, GA LIAO^5,6,*

Oncology Research, Vol.33, No.6, pp. 1405-1421, 2025, DOI:10.32604/or.2024.056708 - 29 May 2025

Abstract Objectives: Exosomal long noncoding RNAs (lncRNAs) might facilitate epithelial–mesenchymal transition (EMT) in liver cancer after transarterial chemoembolization (TACE), thereby enhancing tumor cell invasiveness and migration. This study investigated the prognostic role of plasma exosomal long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) in TACE treated hepatocellular carcinoma (HCC). Methods: Plasma exosomal lncRNA-PVT1 was evaluated via qPCR before and after TACE. Hepatoma cell behavior was investigated in different HCC cell lines. A lncRNA-PVT1 plasmid was synthesized and overexpressed, and si-lncRNA PVT1 was transfected into poorly invasive cells to reveal its influence on cell characteristics. The lncRNA-PVT1–FoxM1 interaction… More > Graphic Abstract

JINGDAN QUAN¹, ZIXIN WAN¹, WEI WU², XINYUAN CAO², JIAYUAN QIU², XIAOYE LIU², ZHIWEI ZHANG^1,*

Oncology Research, Vol.33, No.5, pp. 1069-1089, 2025, DOI:10.32604/or.2025.063005 - 18 April 2025

Abstract One of the most prevalent malignant tumors worldwide, stomach cancer still has a high incidence and fatality rate in China, and the number of young people developing early-onset gastric cancer is steadily increasing. The 5-year survival rate of stomach cancer is typically 30%–35%, the prognosis is bad, the patients’ quality of life is low, and the progression of advanced gastric cancer cannot be effectively managed despite the use of surgical surgery, chemotherapy, and other medicines. We urgently need molecular biomarkers with high specificity and sensitivity to increase the early gastric cancer detection rate, extend patient… More >