Jia Yu, Qiyu Fang, Shuyan Meng

Oncology Research, Vol.27, No.1, pp. 47-53, 2019, DOI:10.3727/096504018X15193843443255

Abstract Non-small cell lung cancer (NSCLC) represents the leading cause of cancer-related mortality worldwide. More and more reports have identified important roles for long noncoding RNAs (lncRNAs) in cancer development. ENST457720 expression was upregulated in lung adenocarcinoma in a microarray-based lncRNA screen. We determined the expression levels of ENST457720 in NSCLC tissues with quantitative real-time PCR and then studied their clinical significance. We explored the biological significance of ENST457720 with gain- and lossof-function analyses in vitro and in vivo. In this study, ENST457720 was expressed at higher levels in NSCLC tissues than in paired normal tissues. More >

Haisong Yang^*, Tengxiang Chen^†, Shu Xu^‡, Shiyong Zhang^*, Mengmeng Zhang^*

Oncology Research, Vol.27, No.2, pp. 219-226, 2019, DOI:10.3727/096504018X15213126075068

Abstract Breast cancer (BC) is the most common malignant tumor in women. Recently, long noncoding RNAs (lncRNAs) have been proposed as critical regulators in biological processes, including tumorigenesis. FOXC2-AS1, a single antisense oligonucleotide RNA transcribed from the negative strand of forkhead box protein C2 (FOXC2), has been identified as an oncogene in osteosarcoma. In the present study, we investigated the prognosis value and biological role of FOXC2-AS1 in BC. Our findings revealed that FOXC2-AS1 was significantly increased in BC tissues and cell lines, and Kaplan–Meier survival analysis indicated that a high level of FOXC2-AS1 was associated More >

Yang Zhang^*†, Min Zhu^‡, Yuanbo Sun^§, Wenyuan Li^*†, Ying Wang^*†, Weiguang Yu^¶

Oncology Research, Vol.27, No.3, pp. 379-387, 2019, DOI:10.3727/096504018X15199531937158

Abstract Breast cancer is one of the major malignancies with a mounting mortality rate in the world. Long noncoding RNA (lncRNA) cancer susceptibility candidate 2 (CASC2) has been identified to regulate the initiation and progression of multiple tumorous diseases according to previous studies. However, its biological role has been rarely reported in breast cancer. In the present study, lncRNA CASC2 was found to be significantly downregulated in breast cancer tissues and cell lines using real-time quantitative PCR. Furthermore, gain-offunction assays demonstrated that overexpression of lncRNA CASC2 significantly repressed breast cancer cell proliferation and metastasis. Moreover, CASC2 More >

Hongliang Yang^*1, Lei Yan^†1, Kai Sun^‡, Xiaodong Sun^†, Xudong Zhang,§ Kerui Cai^†, Tiejun Song^*

Oncology Research, Vol.27, No.3, pp. 359-369, 2019, DOI:10.3727/096504018X15220594629967

Abstract This study aimed to explore the effects of lncRNA BCAR4 on the viability and aggressiveness of non-small cell lung cancer (NSCLC) cells. qRT-PCR was used to determine the expression of BCAR4 and GLI2 downstream genes in NSCLC tissues and cell lines. Chromatin isolation by RNA purification (CHIRP) and Western blot were employed to measure the expression of the GLI2 downstream proteins. Ki-67 expression in nude mice tumors was tested by immunohistochemistry. MTT assay, wound healing assay, and Transwell assay were used to assess NSCLC cell viability and aggressiveness, respectively. Tumor xenograft was conducted to determine the… More >

Zhen Li^*1, Xin Li^*1, Xiao Du^†, Henghui Zhang^†, Zhengyang Wu^*, Kewei Ren^*, Xinwei Han^*

Oncology Research, Vol.27, No.6, pp. 663-672, 2019, DOI:10.3727/096504018X15420741307616

Abstract Cholangiocarcinoma (CCA) is the second most common primary hepatobiliary carcinoma. The long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) has been reported to contribute to the progression of multiple cancers. Nonetheless, the functions and hidden mechanism of SNHG1 remain unclear in CCA. In this study, the SNHG1 levels were boosted in CCA cell lines, and knockdown of SNHG1 repressed CCA cell proliferation and invasion in vitro. The data also demonstrated that miR-140 could act as a target of SNHG1 in CCA and inhibited CCA cell proliferation and invasion, whereas the inhibition effects More >

Zhongyi Mu^*†1, Dan Dong^*1, Ning Wei^‡§, Mingli Sun^¶, Wei Wang^*, Yue Shao^*, Jian Gao^*, Ping Yin^*, Chenghai Zhao^*

Oncology Research, Vol.27, No.6, pp. 653-661, 2019, DOI:10.3727/096504018X15420748671075

Abstract The lncRNA AFAP1-AS1, oriented from an antisense direction to the protein-coding gene AFAP1 in the opposite strand, was upregulated in a variety of tumors and associated with poor prognosis, including lung cancer, breast cancer, ovarian cancer, and so on. However, the biological role of AFAP1-AS1 in clear cell renal cell carcinoma (ccRCC) is still unknown. We observed that AFAP1-AS1 expression was significantly upregulated in ccRCC tissues and that patients with high-level expression of AFAP1-AS1 had a shorter overall survival. Knockdown of AFAP1-AS1 markedly suppressed the progression of proliferation, invasion, migration, and EMT in ccRCC cells.… More >

Wang, Kecheng¹, Zhang, Meng², Wang, Cong², Ning, Xiaofei¹

Oncology Research, Vol.27, No.5, pp. 541-549, 2019, DOI:10.3727/096504018X15234931503876

Abstract THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHERS IN OCTOBER 2020. More >

Hao Xiao^1,*, Jun Zhang², Wenhua Huang³, Mi Zhou⁴, Wencheng Hu⁵

CMC-Computers, Materials & Continua, Vol.61, No.2, pp. 759-775, 2019, DOI:10.32604/cmc.2019.06085

Abstract Combined with the dense coding mechanism and the bias-BB84 protocol, an efficient quantum key distribution protocol with dense coding on single photons (QDKD-SP) is proposed. Compared with the BB84 or bias-BB84 protocols based on single photons, our QDKD-SP protocol has a higher capacity without increasing the difficulty of its experiment implementation as each correlated photon can carry two bits of useful information. Compared with the quantum dense key distribution (QDKD) protocol based on entangled states, our protocol is more feasible as the preparation and the measurement of a single-photon quantum state is not difficult with More >

Ramzi Bchir^1,2,*, Aslam Sami Djellouli¹, Nadia Zitouna³, Didier Aurelle⁴, Gerard Pergent², Christine Pergent-Martini² and Habib Langar¹

Phyton-International Journal of Experimental Botany, Vol.88, No.2, pp. 171-184, 2019, DOI:10.32604/phyton.2019.05261

Abstract Specimens of Cymodocea (Viridiplantae, Magnoliophyta) collected on the Tunisian coasts showed a particular morphological and anatomical difference with the classical descriptions of Cymodocea nodosa (Ucria) Asch. the only species of this genus reported in the Mediterranean Sea. In order to precise the taxonomic identity of the new specimens we aimed in this work (i) to verify the identity of the new forms, (ii) to evaluate the genetic diversity of the population, (iii) to test the validity of the existing identification keys of the Tunisian Cymodocea populations. Four stations located in two regions of the Tunisian More >

Yan Leng^1,2, Yongjun Ren^1,2,*, Chengshan Qian³, Jinyue Xia⁴

Journal on Big Data, Vol.1, No.1, pp. 39-45, 2019, DOI:10.32604/jbd.2019.05870

Abstract With the rapid development of E-commerce and E-government, there are so many electronic records have been produced. The increasing number of electronic records brings about storage difficulties, the traditional electronic records center is difficult to cope with the current fast growth requirements of electronic records storage and management. Therefore, it is imperative to use cloud storage technology to build electronic record centers. However, electronic records also have weaknesses in the cloud storage environment, and one of them is that once electronic record owners or managers lose physical control of them, the electronic records are more More >