Krisztina Buzás1, Klára Megyeri1, Márta Hõgye2, Miklós Csanády2, Gábor Bogáts2, Yvette Mándi1
European Cytokine Network, Vol.15, No.1, pp. 53-59, 2004
Abstract Aims. In order to gain more insight into the pathogenesis of dilated and hypertrophic cardiomyo-pathies
(DCM and HCM, respectively), we investigated the roles of certain cytokines that regulate apoptosis.
Methods and results. ELISA tests, performed to determine the plasma concentrations of tumour necrosis factor-α
(TNF-α), the soluble Fas (sFas), interleukin-6 (IL-6) and the soluble IL-6 receptor (sIL-6R), revealed that DCM
patients exhibit elevated concentrations of TNF-α, sFas, IL-6 and sIL-6R, while HCM patients have only high
IL-6 and sIL-6R levels as compared with healthy individuals. Western blot analysis of the levels of TNF-α, IL-6,
Bcl-2… More >