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  • Open Access

    ARTICLE

    Image Recognition of Breast Tumor Proliferation Level Based on Convolution Neural Network

    Junhao Yang1, Chunxiao Chen1,*, Qingyang Zang1, Jianfei Li1

    Molecular & Cellular Biomechanics, Vol.15, No.4, pp. 203-214, 2018, DOI:10.32604/mcb.2018.03824

    Abstract Pathological slide is increasingly applied in the diagnosis of breast tumors despite the issues of large amount of data, slow viewing and high subjectivity. To overcome these problems, a micrograph recognition method based on convolutional neural network is proposed for pathological slide of breast tumor. Combined with multi-channel threshold and watershed segmentation, a sample database including single cell, adhesive cell and invalid cell was established. Then, the convolution neural network with six layers is constructed, which has ability to classify the stained breast tumor cells with accuracy of more than 90%, and evaluate the proliferation More >

  • Open Access

    ARTICLE

    Tumor Cell Identification in Ki-67 Images on Deep Learning

    Ruihan Zhang1,2, Junhao Yang1, Chunxiao Chen1,*

    Molecular & Cellular Biomechanics, Vol.15, No.3, pp. 177-187, 2018, DOI:10.3970/mcb.2018.04292

    Abstract The proportion of cells staining for the nuclear antigen Ki-67 is an important predictive indicator for assessment of tumor cell proliferation and growth in routine pathological investigation. Instead of traditional scoring methods based on the experience of a trained laboratory scientist, deep learning approach can be automatically used to analyze the expression of Ki-67 as well. Deep learning based on convolutional neural networks (CNN) for image classification and single shot multibox detector (SSD) for object detection are used to investigate the expression of Ki-67 for assessment of biopsies from patients with breast cancer in this More >

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