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  • Open Access

    ORIGINAL ARTICLE

    Assessment of an ultra-sensitive IFNγ immunoassay prototype for latent tuberculosis diagnosis

    Elyes Ben Salah1, Karim Dorgham1, Mylène Lesénéchal2, Camille Pease2, Laure Allard2, Céline Dragonetti2, Guy Gorochov1, Amélie Guihot1, Delphine Sterlin1

    European Cytokine Network, Vol.29, No.4, pp. 136-145, 2018, DOI:10.1684/ecn.2018.0417

    Abstract Worldwide there are about 1.7 billion individuals with latent tuberculosis infection (LTBI) and only 5% to 15% will develop active tuberculosis (TB). It is recommended to treat only those most at risk of develop ing active TB to avoid problems of drug resistance. LTBI diagnosis involves reviewing the individual’s medical history, physical examination, and biological tests. Interferon gamma release assays (IGRA) can yield “undetermi nate” or “uncertain” results, which makes clinical management decisions difficult. We assessed an ultra-sensitive immunoassay prototype based on single molecule array (SiMoA) technology to evaluate its overall performance, and in particular,… More >

  • Open Access

    ARTICLE

    An implementation of next generation sequencing for prevention and diagnosis of urinary tract infection in urology

    Vladimir Mouraviev1, Michael McDonald2

    Canadian Journal of Urology, Vol.25, No.3, pp. 9349-9356, 2018

    Abstract Introduction: The changing face of current infection phenotypes — from planktonic to biofilm type — has increasingly implicated bacterial biofilms in recurrent infections. To date, no specific medical treatment exists that can effectively target biofilms within the human host. Similarly, the identification of biofilms has traditionally relied on tissue sample analysis using electron microscopy or DNA identification via polymerase chain reaction (PCR) and sequencing. Standard culture and sensitivity tests are not capable of detecting the presence of biofilms.
    Materials and methods: Two types or "levels" of molecular microbial diagnostic testing were performed as described below. In both… More >

  • Open Access

    ARTICLE

    Statistical Analysis and Multimodal Classification on Noisy Eye Tracker and Application Log Data of Children with Autism and ADHD

    Mahiye Uluyagmur Ozturka, Ayse Rodopman Armanb, Gresa Carkaxhiu Bulutc, Onur Tugce Poyraz Findikb, Sultan Seval Yilmazd, Herdem Aslan Gencb, M. Yanki Yazgane,f, Umut Tekera, Zehra Cataltepea

    Intelligent Automation & Soft Computing, Vol.24, No.4, pp. 891-905, 2018, DOI:10.31209/2018.100000058

    Abstract Emotion recognition behavior and performance may vary between people with major neurodevelopmental disorders such as Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and control groups. It is crucial to identify these differences for early diagnosis and individual treatment purposes. This study represents a methodology by using statistical data analysis and machine learning to provide help to psychiatrists and therapists on the diagnosis and individualized treatment of participants with ASD and ADHD. In this paper we propose an emotion recognition experiment environment and collect eye tracker fixation data together with the application log data More >

  • Open Access

    ARTICLE

    Fault Diagnoses of Hydraulic Turbine Using the Dimension Root Similarity Measure of Single-valued Neutrosophic Sets

    Jun Ye

    Intelligent Automation & Soft Computing, Vol.24, No.1, pp. 1-8, 2018, DOI:10.1080/10798587.2016.1261955

    Abstract This paper proposes a dimension root distance and its similarity measure of single-valued neutrosophic sets (SVNSs), and then develops the fault diagnosis method of hydraulic turbine by using the dimension root similarity measure of SVNSs. By the similarity measures between the fault diagnosis patterns and a testing sample with single-valued neutrosophic information and the relation indices, we can determine the main fault type and the ranking order of various vibration faults for predicting some possible fault trend. Then, the comparison of the fault diagnoses of hydraulic turbine based of the proposed dimension root similarity measure More >

  • Open Access

    ARTICLE

    Prenatal detection of critical cardiac outflow tract anomalies remains suboptimal despite revised obstetrical imaging guidelines

    Heather Y. Sun1, James A. Proudfoot2, Rachel T. McCandless1

    Congenital Heart Disease, Vol.13, No.5, pp. 748-756, 2018, DOI:10.1111/chd.12648

    Abstract Background: Fetal echocardiography can accurately diagnose critical congenital heart disease prenatally, but relies on referrals from abnormalities identified on routine obstetrical ultrasounds. Critical congenital heart disease that is frequently missed due to inadequate outflow tract imaging includes anomalies such as truncus arteriosus, double outlet right ventricle, transposition of the great arteries, tetralogy of Fallot, pulmonary stenosis, and aortic stenosis.
    Objective: This study evaluated the prenatal detection rate of critical outflow tract anomalies in a single urban pediatric hospital before and after “AIUM Practice Guideline for the Performance of Obstetric Ultrasound Examinations,” which incorporated outflow tract imaging.
    Design: Infants… More >

  • Open Access

    ARTICLE

    Fetal heart size measurements as new predictors of homozygous α-thalassemia-1 in mid-pregnancy

    Xinyan Li1, Xiaoxia Qiu1, Huan Huang1, Yili Zhao2, Xueqin Li1, Meng Li1, Xiaoxian Tian1

    Congenital Heart Disease, Vol.13, No.2, pp. 282-287, 2018, DOI:10.1111/chd.12568

    Abstract Objective: To evaluate the efficacy of using fetal heart size measurements derived from axial echocardiography to predict homozygous α-thalassemia-1.
    Design: Prospective diagnostic study.
    Setting: The carrier rate of α-thalassemia-1 (–/αα) in China’s Guangxi Zhuang Autonomous Region is approximately 15%. If both parents are carriers, the risk of homozygous a-thalassemia-1 in one pregnancy is 25%.
    Patients: Singleton mid-pregnancies at risk of homozygous α-thalassemia-1 were enrolled.
    Outcome Measures: Fetal heart measurements, including heart diameter (HD), heart length (HL), heart circumference (HC), and heart area (HA), were measured. The z-scores for these heart parameters were then calculated separately based on previously constructed z-score… More >

  • Open Access

    ARTICLE

    Comparisons of MFDFA, EMD and WT by Neural Network, Mahalanobis Distance and SVM in Fault Diagnosis of Gearboxes

    Jinshan Lina*, Chunhong Doub, Qianqian Wanga

    Sound & Vibration, Vol.52, No.2, pp. 11-15, 2018, DOI:10.32604/sv.2018.03653

    Abstract A method for gearbox fault diagnosis consists of feature extraction and fault identification. Many methods for feature extraction have been devised for exposing nature of vibration data of a defective gearbox. In addition, features extracted from gearbox vibration data are identified by various classifiers. However, existing literatures leave much to be desired in assessing performance of different combinatorial methods for gearbox fault diagnosis. To this end, this paper evaluated performance of several typical combinatorial methods for gearbox fault diagnosis by associating each of multifractal detrended fluctuation analysis (MFDFA), empirical mode decomposition (EMD) and wavelet transform More >

  • Open Access

    ARTICLE

    Use of Discrete Wavelet Features and Support Vector Machine for Fault Diagnosis of Face Milling Tool

    C. K. Madhusudana1, N. Gangadhar1, Hemantha Kumar, Kumar,*,1, S. Narendranath1

    Structural Durability & Health Monitoring, Vol.12, No.2, pp. 111-127, 2018, DOI:10.3970/sdhm.2018.01262

    Abstract This paper presents the fault diagnosis of face milling tool based on machine learning approach. While machining, spindle vibration signals in feed direction under healthy and faulty conditions of the milling tool are acquired. A set of discrete wavelet features is extracted from the vibration signals using discrete wavelet transform (DWT) technique. The decision tree technique is used to select significant features out of all extracted wavelet features. C-support vector classification (C-SVC) and ν-support vector classification (ν-SVC) models with different kernel functions of support vector machine (SVM) are used to study and classify the tool More >

  • Open Access

    ARTICLE

    Fault Diagnosis of Motor in Frequency Domain Signal by Stacked De-noising Auto-encoder

    Xiaoping Zhao1, Jiaxin Wu1,*, Yonghong Zhang2, Yunqing Shi3, Lihua Wang2

    CMC-Computers, Materials & Continua, Vol.57, No.2, pp. 223-242, 2018, DOI:10.32604/cmc.2018.02490

    Abstract With the rapid development of mechanical equipment, mechanical health monitoring field has entered the era of big data. Deep learning has made a great achievement in the processing of large data of image and speech due to the powerful modeling capabilities, this also brings influence to the mechanical fault diagnosis field. Therefore, according to the characteristics of motor vibration signals (nonstationary and difficult to deal with) and mechanical ‘big data’, combined with deep learning, a motor fault diagnosis method based on stacked de-noising auto-encoder is proposed. The frequency domain signals obtained by the Fourier transform More >

  • Open Access

    ARTICLE

    Feature Selection Method Based on Class Discriminative Degree for Intelligent Medical Diagnosis

    Shengqun Fang1, Zhiping Cai1,*, Wencheng Sun1, Anfeng Liu2, Fang Liu3, Zhiyao Liang4, Guoyan Wang5

    CMC-Computers, Materials & Continua, Vol.55, No.3, pp. 419-433, 2018, DOI:10.3970/cmc.2018.02289

    Abstract By using efficient and timely medical diagnostic decision making, clinicians can positively impact the quality and cost of medical care. However, the high similarity of clinical manifestations between diseases and the limitation of clinicians’ knowledge both bring much difficulty to decision making in diagnosis. Therefore, building a decision support system that can assist medical staff in diagnosing and treating diseases has lately received growing attentions in the medical domain. In this paper, we employ a multi-label classification framework to classify the Chinese electronic medical records to establish corresponding relation between the medical records and disease… More >

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