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  • Open Access

    ARTICLE

    Interferon Gamma Release Assay in response to PE35/PPE68 proteins: a promising diagnostic method for diagnosis of latent tuberculosis

    Shima Mahmoudi1, Babak Pourakbari1, Setareh Mamishi1,2

    European Cytokine Network, Vol.28, No.1, pp. 36-40, 2017, DOI:10.1684/ecn.2017.0391

    Abstract Tuberculosis control relies on the identification and preventive treatment of people who are latently infected with Mycobacterium tuberculosis (Mtb). PE/PPE proteins have been reported to elicit CD4 and/or CD8 responses either in the form of whole recombinant proteins or as individual peptides. Very few of the PE and PPE proteins have been previously tested for responses in patients with TB and healthy donors. This is the first study to evaluate the Interferon Gamma Release Assay (IGRA) after stimulation with PE35 and PPE68. The antigen-specific levels of IFN-γ following stimulation with QuantiFERON-TB gold in-tube (QFT-G-IT) antigens,… More >

  • Open Access

    ARTICLE

    Fluorescence in situ hybridization (FISH) in the diagnosis of bladder and upper tract urothelial carcinoma: the largest single-institution experience to date

    Leonard G. Gomella, Mark J. Mann, Ryan C. Cleary, Scott G. Hubosky, Demetrius H. Bagley, Adeep B. Thumar, Peter A. McCue, Costas D. Lallas, Edouard J. Trabulsi

    Canadian Journal of Urology, Vol.24, No.1, pp. 8620-8626, 2017

    Abstract Introduction: We evaluated the UroVysion (Abbott Molecular, IL, USA) fluorescence in situ hybridization (FISH) assay for the diagnosis of urothelial cancer in patients diagnosed with or suspected to have bladder, upper tract urothelial carcinoma (UTUC), and combined upper and lower tract urothelial carcinoma (BC).
    Materials and methods: A single institution retrospective analysis comparing sensitivity, specificity, positive predictive value, and negative predictive values for FISH and urinary cytology. FISH within 6 months of endoscopic evaluation were obtained from outpatient voided urine samples. Our institutional pathology department confirmed pathologic disease from specimens obtained during endoscopic evaluations for lower tract… More >

  • Open Access

    ARTICLE

    Prostate cancer detection following diagnosis of atypical small acinar proliferation

    Kyle J. Ericson1, Hannah C. Wenger2, Alexandre M. Rosen3, Kyle J. Kiriluk4, Glenn S. Gerber5, Gladell P. Paner6, Scott E. Eggener5

    Canadian Journal of Urology, Vol.24, No.2, pp. 8714-8720, 2017

    Abstract Introduction: To report the incidence and characteristics of cancer following a diagnosis of atypical small acinar proliferation (ASAP) and comment on current clinical practice recommendations.
    Materials and methods: We reviewed patients that underwent prostate biopsy between 2008 and 2013 at a single institution. Men with ASAP without previous cancer were included. Clinicopathologic features including prostate-specific antigen (PSA), presence of ASAP or cancer, tumor volume, number of involved cores, and Gleason score were analyzed in men that received a repeat prostate biopsy.
    Results: Of 1450 men, ASAP was found in 75 (5%) patients. Repeat biopsy was performed in 49… More >

  • Open Access

    ARTICLE

    Family perception of unmet support needs following a diagnosis of congenital coronary anomaly in children: Results of a survey

    Hitesh Agrawal1,2, Oriana K. Wright3, Kathleen E. Carberry1,4, S. Kristen Sexson Tejtel1,2, Carlos M. Mery1,5, Silvana Molossi1,2

    Congenital Heart Disease, Vol.12, No.6, pp. 721-725, 2017, DOI:10.1111/chd.12473

    Abstract Background: Long-term outcome data on patients with anomalous aortic origin of coronary arteries (AAOCA) is sparse and they are often managed in a nonuniform manner. There is subjective perception of anxiety and unmet needs in these patients and families.
    Methods: An online survey of 13 questions was sent to 74 families of patients with AAOCA between May and October 2015. Descriptive statistics were performed.
    Results: A total of 31 (47%) families responded. Of these, 27 expressed the need to interact with other patients/families with AAOCA. The majority were interested in either face-to-face meetings (77%) or online support groups… More >

  • Open Access

    ARTICLE

    Myocardial bridges: Overview of diagnosis and management

    Ian S. Rogers1,2, Jennifer A. Tremmel1, Ingela Schnittger1

    Congenital Heart Disease, Vol.12, No.5, pp. 619-623, 2017, DOI:10.1111/chd.12499

    Abstract A myocardial bridge is a segment of a coronary artery that travels into the myocardium instead of the normal epicardial course. Although it is general perception that myocardial bridges are normal variants, patients with myocardial bridges can present with symptoms, such as exertional chest pain, that cannot be explained by a secondary etiology. Such patients may benefit from individualized medical/ surgical therapy. This article describes the prevalence, clinical presentation, classification, evaluation, and management of children and adults with symptomatic myocardial bridges. More >

  • Open Access

    ARTICLE

    Right aortic arch with situs solitus frequently heralds a vascular ring

    William N. Evans1,2, Ruben J. Acherman1,2, Michael L. Ciccolo1,3, Sergio A. Carrillo1,3, Gary A. Mayman1,2, Carlos F. Luna1,2, Robert C. Rollins1,2, William J. Castillo1,2, Alvaro Galindo1,2, Abraham Rothman1,2, John A. Alexander1,2, Tina W. Kwan1,2, Humberto Restrepo1,2

    Congenital Heart Disease, Vol.12, No.5, pp. 583-587, 2017, DOI:10.1111/chd.12487

    Abstract Objective: We hypothesized that a right aortic arch in situs solitus, with or without an associated cardiovascular malformation, is often associated with a vascular ring.
    Methods: From those born in Southern Nevada between March 2012 and March 2017, we identified 50 (3.6 per 10,000 live births) with a right aortic arch and situs solitus. From the 50 patients, 6 did not meet inclusion criteria for further analysis.
    Results: Of the 44 remaining, 33 (75%) had a vascular ring. Of the 33 with a vascular ring, 26 (79%) occurred with an isolated right aortic arch, and 7 (21%) had More >

  • Open Access

    ARTICLE

    Condition Monitoring of Roller Bearing by K-Star Classifier and K-Nearest Neighborhood Classifier Using Sound Signal.

    Rahul Kumar Sharma*1, V. Sugumaran1, Hemantha Kumar2, Amarnath M3

    Structural Durability & Health Monitoring, Vol.11, No.1, pp. 1-16, 2017, DOI:10.3970/sdhm.2017.012.001

    Abstract Most of the machineries in small or large scale industry have rotating element supported by bearings for rigid support and accurate movement. For proper functioning of machinery, condition monitoring of the bearing is very important. In present study sound signal is used to continuously monitor bearing health as sound signals of rotating machineries carry dynamic information of components. There are numerous studies in literature that are reporting superiority of vibration signal of bearing fault diagnosis. However, there are very few studies done using sound signal. The cost associated with condition monitoring using sound signal (Microphone)… More >

  • Open Access

    ARTICLE

    A Comparative Study of Bayes Classifiers for Blade Fault Diagnosis in Wind Turbines through Vibration Signals

    A. Joshuva1, V. Sugumaran2

    Structural Durability & Health Monitoring, Vol.11, No.1, pp. 69-90, 2017, DOI:10.3970/sdhm.2017.012.069

    Abstract Renewable energy sources are considered much in energy fields because of the contemporary energy calamities. Among the important alternatives being considered, wind energy is a durable competitor because of its dependability due to the development of the innovations, comparative cost effectiveness and great framework. To yield wind energy more proficiently, the structure of wind turbines has turned out to be substantially bigger, creating conservation and renovation works troublesome. Due to various ecological conditions, wind turbine blades are subjected to vibration and it leads to failure. If the failure is not diagnosed early, it will lead… More >

  • Open Access

    ARTICLE

    Brake Fault Diagnosis Through Machine Learning Approaches – A Review

    Alamelu Manghai T.M.1, Jegadeeshwaran R2, Sugumaran V.3

    Structural Durability & Health Monitoring, Vol.11, No.1, pp. 43-67, 2017, DOI:10.3970/sdhm.2017.012.043

    Abstract Diagnosis is the recognition of the nature and cause of a certain phenomenon. It is generally used to determine cause and effect of a problem. Machine fault diagnosis is a field of finding faults arising in machines. To identify the most probable faults leading to failure, many methods are used for data collection, including vibration monitoring, thermal imaging, oil particle analysis, etc. Then these data are processed using methods like spectral analysis, wavelet analysis, wavelet transform, short-term Fourier transform, high-resolution spectral analysis, waveform analysis, etc., The results of this analysis are used in a root More >

  • Open Access

    RESIDENT’S CORNER

    Pediatric emphysematous cystitis: a report and review of a rare diagnosis in children

    Matthew A. Uhlman, Eric D. Andresen, Douglas W. Storm

    Canadian Journal of Urology, Vol.22, No.4, pp. 7924-7926, 2015

    Abstract An 11-year-old female with spastic quadriplegia was seen in the emergency room with abdominal pain, vomiting and anorexia. Labs revealed possible pancreatitis and signs of a urinary tract infection. A CT scan was performed to assess her abdominal pain and demonstrated circumferential air within the bladder wall. Following cultures being drawn, she was started on broad spectrum antibiotics. Her urine eventually grew Klebsiella pneumoniae. Follow-up imaging 2 weeks later demonstrated resolution of the air. Emphysematous cystitis is an exceedingly rare condition in the pediatric population, with this report representing the second case within the literature. More >

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