Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 179-180, 2006, DOI:10.32604/mcb.2006.003.179

Abstract This article has no abstract. More >

S. Williams¹, G. Reilly², A. Sittichokechaiwut², D. A. Clarke², T. Nickel¹, L. Mejia¹

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 137-138, 2006, DOI:10.32604/mcb.2006.003.137

Abstract This article has no abstract. More >

D. L. Butler¹, N. Juncosa-Melvin¹, G. P. Boivin¹, M. Galloway², C. Gooch¹, J. T. Shearn¹, V. S. Nirmalanandhan¹, S. A. Hunter¹, K. Chokalingam¹, C. Frede³, J. Florer³, R. Wenstrup³

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 127-130, 2006, DOI:10.32604/mcb.2006.003.127

Abstract This article has no abstract. More >

Marcello Lappa¹

FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.2, pp. 141-152, 2006, DOI:10.3970/fdmp.2006.002.141

Abstract Numerical simulations and computer-graphics animation can be used as useful tools to discern the physicochemical environmental factors affecting the surface kinetics of growing biological tissues as well as their relative importance in determining growth. A mathematical formalism for such kinetics is proposed through parametric investigation and validated through focused comparison with experimental results. The study relies on the application of a CFD moving boundary (Volume of Fluid) method specially conceived for the simulation of these problems. In the second part of the analysis the case of two samples hydrodynamically interacting in a rotating bioreactor is More >

Milica Radisic^1,2, Gordana Vunjak-Novakovic³

FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.1, pp. 1-16, 2006, DOI:10.3970/fdmp.2006.002.001

Abstract To engineer cardiac tissue in vitro with properties approaching those of native tissue, it is necessary to reproduce many of the conditions found in vivo. In particular, cell density must be sufficiently high to enable contractility, which implies a three-dimensional culture with a sufficient oxygen and nutrient supply. In this review, hydrogels and scaffolds that support high cell densities are examined followed by a discussion on the utility of scaffold perfusion to satisfy high oxygen demand of cardiomyocytes and an overview of new bioreactors developed in our laboratory to accomplish this task more simply. More >

P. Yu¹, T. S. Lee¹, Y. Zeng¹, H. T. Low²

FDMP-Fluid Dynamics & Materials Processing, Vol.1, No.3, pp. 235-246, 2005, DOI:10.3970/fdmp.2005.001.235

Abstract A numerical model is developed for the investigation of flow field and mass transport in a micro-bioreactor, of working volume below 5 ml, in which medium mixing is generated by a magnetic stirrer-rod rotating on the bottom. The flow-field results show that a recirculation region exists above the stirrer rod and rotates with it; the related fluid mixing is characterized by a circulation coefficient of up to 0.2 which is about five times smaller than that of a one-litre stirred-tank bioreactor. The oxygen transfer coefficient is less than 5 h^-1 which is two orders smaller than… More >

D.E. Ingber¹

Molecular & Cellular Biomechanics, Vol.1, No.1, pp. 53-68, 2004, DOI:10.3970/mcb.2004.001.053

Abstract This article is a summary of a lecture presented at a symposium on "Mechanics and Chemistry of Biosystems'' in honor of Professor Y.C. Fung that convened at the University of California, Irvine in February 2004. The article reviews work from our laboratory that focuses on the mechanism by which mechanical and chemical signals interplay to control how individual cells decide whether to grow, differentiate, move, or die, and thereby promote pattern formation during tissue morphogenesis. Pursuit of this challenge has required development and application of new microtechnologies, theoretical formulations, computational models and bioinformatics tools. These… More >

Gang Bao¹, Andrew Tsourkas², Philip J. Santangelo²

Molecular & Cellular Biomechanics, Vol.1, No.1, pp. 23-36, 2004, DOI:10.3970/mcb.2004.001.023

Abstract The ability to detect, localize, quantify and monitor the expression of specific genes in living cells in real-time will offer unprecedented opportunities for advancement in molecular biology, disease pathophysiology, drug discovery, and medical diagnostics. However, current methods for quantifying gene expression employ either selective amplification (as in PCR) or saturation binding followed by removal of the excess probes (as in microarrays and in situ hybridization) to achieve specificity. Neither approach is applicable when detecting gene transcripts within living cells. Here we review the recent development in engineering nanostructured molecular probes for gene detection in vivo, describe More >

Z.Y. Qian¹, Z.D. Han¹, S.N. Atluri¹

CMES-Computer Modeling in Engineering & Sciences, Vol.6, No.1, pp. 115-122, 2004, DOI:10.3970/cmes.2004.006.115

Abstract This article has no abstract. More >