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  • Open Access

    ARTICLE

    Diagnostic and classification value of immune-related lncRNAs in dilated cardiomyopathy

    CONGCHEN BAI1, QIHANG KONG2, HAO TANG2, SHUWEN ZHANG2, JUNTENG ZHOU3,*, XIAOJING LIU2,4,*

    BIOCELL, Vol.47, No.11, pp. 2517-2533, 2023, DOI:10.32604/biocell.2023.043864

    Abstract Background: Various physiological mechanisms are linked to dilated cardiomyopathy (DCM) development, including oxidative stress, immune irregularities, inflammation, fibrosis, and genetic changes. However, precise molecular drivers of DCM, especially regarding abnormal immune responses, remain unclear. This study investigates immune-related long non-coding RNAs (lncRNAs) in DCM’s diagnostic and therapeutic potential. Methods: GSE141910, GSE135055, and GSE165303 datasets were acquired from the GEO database. LASSO, SVM-RFE, and random forest algorithms identified DCM-associated immune-related lncRNAs. Diagnostic capabilities were assessed by Nomogram and receiver operating characteristic (ROC) curves. Multivariate linear regression explored lncRNA correlations with ejection fraction. Single-sample gene set enrichment analysis (ssGSEA) gauged immune cell… More > Graphic Abstract

    Diagnostic and classification value of immune-related lncRNAs in dilated cardiomyopathy

  • Open Access

    ARTICLE

    A prognosis model for predicting immunotherapy response of esophageal cancer based on oxidative stress-related signatures

    JING GUO1, CHANGYONG TONG1, JIANGUANG SHI1, XINJIAN LI1, XUEQIN CHEN2,*

    Oncology Research, Vol.32, No.1, pp. 199-212, 2024, DOI:10.32604/or.2023.030969

    Abstract Oxidative stress (OS) is intimately associated with tumorigenesis and has been considered a potential therapeutic strategy. However, the OS-associated therapeutic target for esophageal squamous cell carcinoma (ESCC) remains unconfirmed. In our study, gene expression data of ESCC and clinical information from public databases were downloaded. Through LASSO-Cox regression analysis, a risk score (RS) signature map of prognosis was constructed and performed external verification with the GSE53625 cohort. The ESTIMATE, xCell, CIBERSORT, TIMER, and ImmuCellAI algorithms were employed to analyze infiltrating immune cells and generate an immune microenvironment (IM). Afterward, functional enrichment analysis clarified the underlying mechanism of the model. Nomogram… More >

  • Open Access

    ARTICLE

    Characterization of prognosis and immune infiltration by a novel glutamine metabolism-related model in cutaneous melanoma

    MENGQIN ZHU1,2,3,4,#, TIANYI XU5,#, HAN ZHANG3,4, XIN FAN3,4, YULAN WANG6, JIAJIA ZHANG3,4, FEI YU1,2,3,4,*

    BIOCELL, Vol.47, No.9, pp. 1931-1945, 2023, DOI:10.32604/biocell.2023.028968

    Abstract Glutamine metabolism (GM) plays an important role in tumor growth and proliferation. Skin cutaneous melanoma (SKCM) is a glutamine-dependent cancer. However, the molecular characteristics and action mechanism of GM on SKCM remain unclear. Therefore, we aimed to explore the effects of GM-related genes on survival, clinicopathological characteristics, and the tumor microenvironment in SKCM. In this study, 682 SKCM samples were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Consensus clustering was used to classify SKCM samples into distinct subtypes based on 41 GM-related genes. Differences in survival, immune infiltration, clinical characteristics, and Kyoto Encyclopedia of… More > Graphic Abstract

    Characterization of prognosis and immune infiltration by a novel glutamine metabolism-related model in cutaneous melanoma

  • Open Access

    ARTICLE

    Polo-like kinase 1 suppresses lung adenocarcinoma immunity through necroptosis

    PENGCHENG ZHANG1,#,*, XINGLONG ZHANG2,#, YONGFU ZHU3, YIYI CUI1, JING XU4, WEIPING ZHANG1,*

    Oncology Research, Vol.31, No.6, pp. 937-953, 2023, DOI:10.32604/or.2023.030933

    Abstract Polo-like kinase 1 (PLK1) plays a crucial role in cell mitosis and has been associated with necroptosis. However, the role of PLK1 and necroptosis in lung adenocarcinoma (LA) remains unclear. In this study, we analyzed The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression databases to evaluate the prognostic value and mechanistic role of PLK1 in LA. PLK1 was found to be highly expressed in LA and was positively associated with advanced disease staging and poor survival outcomes. Functional enrichment analysis showed that PLK1 was involved in cell mitosis, neurotransmitter transmission, and drug metabolism. Further analysis using single-sample gene set enrichment… More > Graphic Abstract

    Polo-like kinase 1 suppresses lung adenocarcinoma immunity through necroptosis

  • Open Access

    ARTICLE

    Immunogenic cell death-related long noncoding RNA influences immunotherapy against lung adenocarcinoma

    DONGJIE SUN1,2, CHI ZHANG3,*

    Oncology Research, Vol.31, No.5, pp. 753-767, 2023, DOI:10.32604/or.2023.029287

    Abstract Lung adenocarcinoma (LUAD) is the leading cause of cancer-related deaths, accounting for over a million deaths worldwide annually. Immunogenic cell death (ICD) elicits an adaptive immune response. However, the role of ICD-related long noncoding RNAs (lncRNAs) in LUAD is unknown. In this study, we investigated the characteristics of the tumor microenvironment in LUAD, the prognostic significance of ICD-related lncRNAs, and the half-maximal inhibitory concentration (IC50) of possible chemotherapeutic drugs. We sorted prognostic lncRNAs using univariate Cox regression and constructed a risk signature based on them. We then confirmed the model’s accuracy and generated a nomogram. Additionally, we performed immune microenvironment… More > Graphic Abstract

    Immunogenic cell death-related long noncoding RNA influences immunotherapy against lung adenocarcinoma

  • Open Access

    ARTICLE

    INFLUENCE OF PORE WALL SURFACE PROPERTY ON FLUX OF CYLINDRICAL-SHAPED NANOPOROUS FILTERING MEMBRANE

    Yongbin Zhang*

    Frontiers in Heat and Mass Transfer, Vol.9, pp. 1-6, 2017, DOI:10.5098/hmt.9.26

    Abstract The influence of pore wall surface property on the flux of a novel cylindrical-shaped nanoporous filtering membrane is analytically studied by using the flow factor approach model for a nanoscale flow. Across the thickness of the membrane are manufactured two concentric cylindrical pores with different radii. The smaller nanoscale pore is for filtration, while the other larger pore is for reducing the flow resistance. It was found that when the larger pore wall surface is hydrophobic, the interaction between the filtered liquid and the smaller pore wall surface has a very significant effect on the value of the optimum ratio… More >

  • Open Access

    ARTICLE

    A TREE-TYPE CYLINDRICAL-SHAPED NANOPOROUS FILTERING MEMBRANE

    Yongbin Zhang*

    Frontiers in Heat and Mass Transfer, Vol.10, pp. 1-5, 2018, DOI:10.5098/hmt.10.16

    Abstract A tree-type cylindrical-shaped nanoporous filtering membrane is proposed. Across the thickness of this membrane are manufactured two kinds of pores i.e. one trunk pore and four uniform branch pores, these two kinds of pores have the same homogeneous surface property and are linked together, and they are uniformly distributed on the membrane surface; The branch pore is for filtration and its radius is on the 1nm or 10nm scales, while the trunk pore is for collecting the flow coming from its four branch pores and it is aimed for reducing the flow resistance and increasing the flux of the membrane;… More >

  • Open Access

    ARTICLE

    TREE-TYPE NANOPOROUS FILTERING MEMBRANE WITH COMPLEX PORES

    Yongbin Zhang*

    Frontiers in Heat and Mass Transfer, Vol.11, pp. 1-5, 2018, DOI:10.5098/hmt.11.32

    Abstract A tree-type nanoporous filtering membrane with complex pores is proposed. The membrane consists of three kinds of concentric cylindrical pores across the membrane thickness i.e. the four branch pores for filtration, the one flow-collecting pore and the one flow resistance-reducing pore. The ratio of the radius of the flow resistance-reducing pore to that of the filtration pore is optimized for yielding the highest flux of the membrane. The dimensionless lowest flow resistance of the membrane in the optimum condition was typically calculated for different filtration pore radii and different passing liquid-pore wall interactions. The capability of the membrane for a… More >

  • Open Access

    ARTICLE

    PERFORMANCE OF THE OPTIMIZED TREE-TYPE CYLINDRICALSHAPED NANOPOROUS FILTERING MEMBRANES WITH 9 OR 10 BRANCH PORES IN EACH PORE TREE

    Yongbin Zhang*

    Frontiers in Heat and Mass Transfer, Vol.11, pp. 1-5, 2018, DOI:10.5098/hmt.11.26

    Abstract The paper analytically studies the performance of the optimized tree-type cylindrical-shaped nanoporous filtering membranes with 9 or 10 branch pores in each pore tree. The optimum ratio of the radius of the trunk pore to the radius of its branch pore was found. The corresponding lowest flow resistances of the membranes were typically calculated respectively for weak, medium and strong liquid-pore wall interactions. For liquid-liquid separations, the optimum radii of the trunk pore in the membranes were calculated according to the weak liquid-pore wall interaction. The capability of the liquidliquid separation of the membranes was also studied. The obtained results… More >

  • Open Access

    ARTICLE

    AN OPTIMIZED TREE-TYPE CYLINDRICAL-SHAPED NANOPOROUS FILTERING MEMBRANE

    Yongbin Zhang*

    Frontiers in Heat and Mass Transfer, Vol.11, pp. 1-7, 2018, DOI:10.5098/hmt.11.25

    Abstract A tree-type cylindrical-shaped nanoporous filtering membrane is optimized with two levels of branches and a lot of branch pores. In this membrane, the branch pores are parallel with their trunk pore and their radius More >

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